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نسیم سخن کی ایک جھلک

نسیم سخن کی ایک جھلک
تقریر ایک ایسا فن سے جس سے انسان اپنا مافی الضمیر موثر انداز میں پیش کرنے کے قابل ہوتا ہے۔ تاریخ عالم گواہ ہے کہ تقریر پر ملکہ رکھنے والے سیاست دانوں نے ملکوں کی قیادت سنبھالی اور عوام کی ذہن سازی میں اپنا کردار ادا کیا۔ سامعین سے خطاب کرنا ہر کسی کے بس کی بات نہیں۔ مبارک باد کے مستحق ہیں مولانا اکرم راشدؔ جو فنِ تقریر میں یدِ طولیٰ رکھتے ہیں۔ انھیں سیاسی علائق سے سروکار نہیں۔ اُن کے خطابات نسلِ نو کی روحانی تربیت سے متعلق ہیں۔
چوں کہ وہ درس و تدریس سے وابستہ رہے اور اب عارف والا کی ایک مسجد میں خطابت کے فرائض انجام دے رہے ہیں۔ اس لیے ان کی تقاریر کے موضوعات روحانی ، اصلاحی اور ملکی فلاح کے علم بردار ہیں۔ انھوں نے اپنے اس مجموعے نسیم سخن میں سو سے زائد موضوعات پر اپنی تقاریر جمع کر دی ہیں۔ان کے موضوعات کا دائرہ ملکِ پاکستان ،دین اسلام، نظامِ تعلیم اور فرد کی اصلاح سے لے کرسماجی مسائل تک پھیلا ہوا ہے جس سے بخوبی اندازہ لگایا جا سکتا ہے کہ وہ اپنے تہذیبی تشخص کو نسلِ نو تک منتقل کرنے کے لیے کتنے فکر مند ہیں۔
راشدؔ صاحب کا یہ مجموعہ تقریرایک طرف فرد کو ملک کا ذمہ دار شہری بنانے کا نصاب اپنے اندر سموئے ہوئے ہے تو دوسری طرف سکول کے طلبا و طالبات کے لیے تقریری مقابلہ جات کی ضرورت پوری کرتا نظر آتا ہے۔ انھوں نے اپنے اس گلدستہ تقاریر کو منفرد اور بر محل اشعار سے مزین کرنے کے ساتھ ساتھ قرآن و حدیث کے حوالوں سے جو درجہ استناد عطا کیا ہے وہ یقیناقابلِ داد ہے۔
وہ اپنی بات کی اہمیت واضح کرنے کے لیے عملی زندگی کی مثالوں کا استعمال کرتے ہیں۔...

ڈاکٹر محمود احمد غازی اور علم حدیث

Islam has been a subject of great importance for Muslim and Non-Muslim Scholars. Countless numbers of researchers have written on the Quran, Hadith, Fiqh and Islamic History. Among these scholars Dr. Mahmood Ahmad Ghazi (1950-2010) is renowned for his contribution to Islamic social sciences. He was equally well versed in the classical, as well as, modern scholarly trends in the study of Islam. He worked in various academic, administrative and judicial positions during his life including as professor, Director Da’wah Academy, Director Shariah Academy, Vice President Academics and then President of International Islamic University, Islamabad and was finally elevated in 2010 as a judge at Federal Shariah Court of Pakistan where he served till the end of his life. He was a prolific writer and authored nearly thirty works of high academic value in different Islamic social sciences including Economics, law and Islamic education in Arabic, English and Urdu languages. He attended a large number of conferences across the globe to present his research papers.

Microbiology and Phage Therapy of Diabetic Foot Ulcer

Diabetic foot infections (DFI) are a major complication of diabetes mellitus. It contributes to the development of gangrene and non-traumatic lower extremity amputations with the life time risk up to 25 %. Since bacteria responsible for chronic wound infections are commonly within polysaccharide matrices known as biofilms, which to a large extent are refractory to antibiotics even when the bacteria are genetically susceptible to their action. In the first part of the study, we identified the neuropathy, ulcer grade, microbial profile, phenotypic and genotypic resistance prevalence of methicillin and ESBL genes in bacterial isolates of DFI patients registered at PIMS, Pakistan. Our results indicated that 46 (92 %) out of 50 patients, had sensory neuropathy. The most prevelant isolate was Staphylococcus aureus (25 %), followed by Pseudomonas aeruginosa (18.18%), E. coli (16.16%), Streptococcus spp (15.15%), Enterococcus spp (9%), Proteus spp (15.15%) and Klebsiella pneumonia (3%). The prevalence of MecA gene was found to be 88 % and 84% phenotypically and genotypically respectively. K. pneumonia had highest percentage of ESBL producers with 66.6 % prevalence by double disc synergy test and 100 % for CTX+CL/CAZ+CL by combination disc test. Pseudomonas aeruginosa had highest (100 %) number of metalo β-lactamase producers by EDTA synergy disk test. Overall prevalence of bla-CTX-M, bla-CTX-M15, bla-TEM, bla-OXA and bla-SHV genes was found to be 76.92, 76.92, 75.0, 57.69 and 84.6 % respectively in gram negative isolates from DFI. Molecular epidemiology of MecA and ESBL genes were found alarmingly high in DFI, posing one of the major cause of antibiotic treatment failure. In the second part of our study we determined whether combinations of antibiotics and bacteriophage were more effective for the treating biofilm populations of Abstract xvii Pseudomonas aeruginosa [the laboratory strain PA14, and the clinical strain, CFBR2)] on plastic surfaces and layers of human epithelial cells. Two newly isolated bacteriophage NP1 and NP3 at a titer of ~1E8 pfu/ml were added individually or as pairs and/or in combination with 1X MIC, 4XMIC and 8X MIC of ceftazidime, colistin, gentamicin or trobramycin to 48 hours PA biofilms in 6 well polystyrene plates. Parallel experiments were performed with 8-hour biofilm populations of epithelial Naso pharyngeal Detroit 562 (ATCC® CCl-138TM). Treatment with phage reduces the viable density of biofilm populations of P. aeruginosa. biofilms by three orders of magnitude as compared to untreated control. In combination with antibiotics phages are more effective than alone and increase efficacy of the antibiotics for treating bacteria in biofilms. In the third part of study we explored co-evolutionary dynamics of resistance between Pseudomonas aeruginosa 14 and its phages NP1 and NP3. Evolutionary dynamics experiments of single and two phages revealed that PA14 can easily evolve resistance against NP1 phage. NP3 phage maintained for 30 serial transfers and we observed host range in evolved bacteria. In cocktail, both phage support each for their long term maintenance in serial transfer experiments. Also, cocktail delayed the evolution of resistance and sustained high phage infectivity, suggesting phage cocktail is promising strategy to control or slow down evolution of resistance in bacteria against bacteriophages.
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