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نواب ناظر یار جنگ

نواب ناظر یارجنگ
نواب ناظر یارجنگ مرحوم ہماری پرانی بزم کی یادگار تھے، اس کی ساری خوبیاں ان میں جمع تھیں، وہ ایک بڑے باپ مولوی نظام الدین حسن مرحوم کے فرزند، خود حیدرآباد ہائیکورٹ کے جج اور اپنے اوصاف کے اعتبار سے بڑے آدمی تھے، وہ علی گڑھ کالج کے ابتدائی دور کے اولڈ بوائے تھے، اب شائد ہی ان کا کوئی معاصر زندہ ہو اور آخر تک ان کو اس سے وابستگی رہی، مدتوں مسلم یونیورسٹی کورٹ اور ایگزیکیٹو کونسل کے ممبر اور اس کے کاموں میں عملی حصہ لیتے رہے، ججی کے عہدے سے عرصہ ہوا ریٹائر ہوچکے تھے اور اپنا وقت حیدرآباد کے قومی و ملی کاموں میں صرف کرتے تھے، دارالمصنفین کی مجلس انتظامیہ کے پرانے رکن اور اس کے ہمدرد و ہوا خواہ تھے، ان سب سے بڑھ کر وہ عملاً مرد مومن تھے، ان کی موت سے ایک پرانی یادگار مٹ گئی، اﷲ تعالیٰ ان کی مغفرت فرمائے۔ (شاہ معین الدین ندوی،ستمبر ۱۹۶۶ء)

Parliamentary System and Framing of the 1973 Constitution: Contest between Government and Opposition inside the National Assembly

It is generally believed that the Constitution of 1973 was passed unanimously by the parliament of Pakistan and was equally acceptable for all the federating units. While studying the processes of the approval of the said constitution inside the assembly, it becomes evident that the reality was quite different. There exists an argument that most of the Opposition members were not allowed to join the parliament’s session while the final approval of the constitution was processed. The present paper is an effort to analyse the developments that took place inside the National Assembly to pass this document which was to serve as the fundamental document of the state system in forthcoming years. In other words, the present article analyses the course of action through which the Constitution was framed. This is an analytical study primarily based on the National Assembly debates supported by the secondary sources, biographies, and autobiographies of the contemporary politicians to understand how far the amendments suggested by the then opposition were accommodated by the ruling party. Furthermore, this paper analyses the reasons for which each government has to amend the basic structure of the constitution to make it more practical and acceptable for its units. For instance the Eighteenth Amendment removed the concurrent list of the constitution but now the following governments are facing issues to implement the Amendment in detail.

Synthesis and Biological Evaluation of Benzothiazole, Thiadiazole and Isatin Derivatives

This thesis divided into four chapters and each chapter includes its own number of derivatives and references. Due to great biological significance of heterocyclic compounds, here in this dissertation we have described synthesis and bioactivities of benzothiazole, thiadiazole and isatin analogs in search of important therapeutic agents. Variety of benzothiazole, thiadiazole and isatin analogs were synthesized, characterized by 1HNMR, 13CNMR and HR-EIMS and screened for enzyme inhibition studies (α-glucosidase, α-amylase and thymidine phosphorylase activities). The results are separately discussed in the forthcoming chapter 1, 2 and 3. In first chapter, Benzothiazole based oxadiazole derivatives (122-144) have been synthesized and evaluated for α-glucosidase inhibition. All analogs exhibited a varying degree of α-glucosidase inhibitory potential with IC50 values ranging in between 0.5 ± 0.01 - 30.90 ± 0.70 μM when compared with the standard acarbose (IC50 = 866.30 ± 3.20 μM). In second chapter, two series of thiadiazole are described. In first series, thiadiazole quinoline analogs (180-209) were synthesized and screened for α-amylase inhibitory potential. Thirteen analogs 180, 181, 182, 183, 184, 185, 201, 202, 204, 205, 206, 207 and 209 showed outstanding α-amylase activity with IC50 values ranges between (0.002 ± 0.60 to 42.31 ± 0.17 μM) which is many folds better than standard acarbose having IC50 value 53.02 ± 0.12 μM. Eleven analogs 190, 192, 193, 194, 195, 197, 198, 200, 201, 202 and xxx 207 showed good to moderate inhibitory potential while seven analogs 187, 192, 195, 199, 200 and 208 were found inactive. In second series, 2-amino-thiadiazole based Schiff bases (211–219) were synthesized and screened for α-glucosidase inhibitory activity. All compounds showed outstanding α-glucosidase inhibition ranging between 2.30 ± 0.1μM to 25.30 ± 0.5μM when compared with the standard inhibitor acarbose having IC50 value 39.60 ± 0.70μM. Among the series, analogs 211, 214, 216 and 217 showed potent α-glucosidase activity which was more active than standard acarbose. The remaining analogs also showed excellent α-glucosidase inhibition. In third chapter, a new class of exceptionally potent isatin based oxadiazole (88-117) has been synthesized and evaluated for thymidine phosphorylase inhibitory potential. All analogs showed potent thymidine phosphorylase inhibition when compared with standard 7-Deazaxanthine, 7DX (IC50 = 38.68 ± 1.12 μM). In chapter four, procedures for different biological assay are described.
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