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رام بابو سکسینہ

رام بابو سکینہ
افسوس ہے کہ گزشتہ مہینہ اردو زبان کے مشہور محسن اور نامور مصنف رام بابو سکسینہ بھی ہم سے جدا ہوگئے۔ ابھی گزشتہ ہی مہینہ ۹؍ دسمبر کو ان سے ہندوستانی اکیڈمی کے جلسہ میں ملاقات ہوئی تھی، کیا معلوم تھا کہ یہ آخری ملاقات ہے، ان کو اردو زبان کی خدمت سے عشق تھا اور اس کو انھوں نے زندگی کا مشغلہ بنالیا تھا اور اردو زبان و ادب کی تاریخ پر بڑی قابل قدر کتابیں لکھیں۔ ان میں تاریخ ادب اردو بہت مشہور اور اس موضوع پر پہلی جامع و محققانہ کتاب ہے، اب اردو کے مختلف پہلوؤں پر بہت سی کتابیں لکھی جاچکی ہیں، مگر اس کتاب کی اولیت اپنی جگہ پر قائم ہے، اردو کے یورپین شعراء کا ایک ضخیم اور محققانہ تذکرہ بھی عرصہ ہوا لکھا تھا، ابھی تھوڑے ہی دن ہوئے قدیم شعراء کا ایک مرقع اور میر کی مثنویاں بخط میر شائع کی تھیں، ان کے علاوہ ان کی اور تصانیف بھی ہیں، جو ابھی شائع نہیں ہوسکی ہیں، اردو کی ایسی خدمت کی مثالیں اس دور میں کم ملیں گی، ابھی ہندوستانی اکیڈمی کے جلسہ میں جہاں پورا ماحول اردو کا مخالف تھا۔ اس کی صریح حمایت میں تنہا ان ہی کی آواز بلند ہوئی تھی، ہندوستان کی موجودہ فضا کو دیکھتے ہوئے ہندوؤں میں آئندہ اردو کے ایسے شیدائی پیدا ہونے کی امید کم ہے۔
یادگار زمانہ تھے یہ لوگ
سن رکھو تم فسانہ تھے یہ لوگ
(شاہ معین الدین ندوی،جنوری ۱۹۵۸ء)

 

تکملہ فتح الملہم میں متون احادیث کی لغوی تحقیق و مباحث

The discipline of Hadith Studies is one of the richest and exclusive disciplines of knowledge as its branches extend to hundred. The religious scholars had written thousands monographs concerning Hadith interpretations and explana-tions. Many voluminous works appeared and exist and each of them is a commendable contribution to Hadith explanations. One of significant works on Hadith explanations is “Takmila Fath al-Mulhim” that is the result of scholastic efforts of many years by Mufti Muhammad Taqi Usmani. This explanation of Hadith Book Muslim was originated and finished till the “section of Marriage” by Allama Shabbir Ahmad Usmani but he could not extend to it to the last chapter due to his political engagements and later his demise closed the chapter. Molana Muhammad Taqi Usmani completed the remaining works in 18 years & 9 months. His method of interpretation is to decipher complicated, manifold and exotic words at first as the words plays key role in authentication and validity of any connotation. He provides detailed information regarding literal and lexical meaning of a word and then with proper justification and reasoning, he gives preference to someone. He also narrates variation and diversity of meaning attached to any word and proves his standpoint about meanings with allied arguments. This article analyses his method with examples and implications.

Pharmacological Prospecting of Rhus Punjabensis Stewart, Bioassay Guided Isolation and Characterization of Lead Compounds

The endorsement of ethno-botanical data from the under explored folk plant remedies represent an illimitable reservoir of novel compounds for drug discovery. Nature has always been the most imperative source of novel drugs against a number of unremitting and challenging health anomalies since antiquity. The present work was aimed to discover natural compounds from untapped natural source. After an extensive survey and information gathered by local vicinity, Rhus punjabensis Stewart (Anacardiaceae) plant was selected from Pakistan for investigation. For initial screening, a total of 22 extracts from leaf and stem parts of R. punjabensis were prepared by using total ‗11‘ different extraction solvent of escalating polarity. All these extracts were subjected to standard phytochemical and in-vitro biological evaluation. The phytochemical assays included standard chromogenic assays for the determination of total phenolic (TP) and total flavonoid contents (FC) and specific polyphenol quantification by RP-HPLC. Multimode antioxidant, antimicrobial, cytotoxic, antileishmanial, nuclear factor kappa-B (NF-κB) and mitochondrial transmembrane potential (MTP) detection assays were employed to assess the in-vitro biological prospective of the subject plants. All-inclusive, the results of initial screening were promising and led to the selection of R. punjabensis leaves as the most bioactive plant material for further appraisal. Briefly, maximum total phenolic and flavonoid contents were determined in the polar solvents extracts whereas, substantial amounts of gallic acid, rutin, apigenin and catechin were quantified in the moderately polar solvents extracts. A proficient antioxidant stature in terms of DPPH free radical scavenging (FRSA), total antioxidant capacity (TAC) and reducing power potential (RP) was also manifested by the moderately polar extracts of R. punjabensis leaves. A noteworthy antibacterial activity (MIC 1.11 µg/mL) against S. typhimurium. Sulphorhodamine B (SRB) cytotoxicity against human cancer cell lines (DU-145, IC50 value of 11.11 µg/mL), (HL-60, IC50 value of 10.82 µg/mL), and NF-κB based chemo-preventive proficiency was demonstrated by the ethyl acetate leaf extract.. All the extracts/fractions were tested for their anticancer and cancer chemopreventive activity by employing different independent assays. Overall the results of the initial screening were very encouraging and led to the selection of the most potent plant material for further investigation. Keeping in view the results of aforementioned assays, ethyl acetate was selected as the extraction solvent to proceed for preparative scale extraction. A total of 6 fractions were prepared from the crude ethyl acetate extract of leaves (863 g) by employing solid phase extraction as the fractionation technique. Bioassay directed isolation from active fractions using column chromatography led to the isolation of 5 bioactive compounds, n-hexane (n-hex), chloroform+n-hexane (n-hex+CHCl3) and ethyl acetate (EtOAc) fractions showed significant activities against tested bioassays. Structural elucidation of these compounds was conceded by infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (1D and 2D NMR) and mass spectrometry (MS). Compound 1 (RPPEC1) showed substantial antibacterial potential against S. typhimurium and B. bronchiseptica (MIC: 11.11 µg/mL) as well as antileishmanial activity (IC50 11.6 µg/mL). Compound 2 (PEEA-C2) demonstrated noteworthy cytotoxic activities against DU-145 and HL-60 human cancer cell lines with an IC50 value of 11.2 and 15.2 μg/mL, respectively. It also exhibited chemopreventive prospective in terms of inhibition of NF-κB (IC50 value of 19.4 μg/mL) and MTP (IC50 value of 28.6 μg/mL). Compound 3 (PEEA-C3) manifested noteworthy cytotoxicity against DU-145 cell line (IC50 value of 21.72 μg/mL). Compound 5 (RPEA-C5) demonstrated significant antibacterial spectrum against all the tested gram positive and gram negative strains while compound 4 manifested significant antibacterial activity against S. typhimurium (MIC 11.1 μg/mL) and cytotoxicity against DU-145 cell line (IC50 value of 29.5 μg/mL). The present study have been reported for the first time from R. punjabensis total five bioactive compounds were isolated, among them compound 4 (RPEA-C4) is a new compound.
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