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عمر سعید

ایڈیٹر برہان کو صدمہ
قارئین برہان کو یہ معلوم کرکے افسوس ہوگاکہ ۱۰؍جولائی کومولانا سعیداحمد اکبرآبادی مدیر برہان کاجواں سال بیٹا ’’عمر سعید‘‘ عمر۴۰ سال مختصر علالت کے بعد انتقال کرگیا۔ اِنَّالِلّٰہِ وَاِنَّااِلَیْہِ راجعون۔
مولانا کو مفتی صاحب ؒ کی وفات کاصدمۂ جانکاہ ابھی تازہ ہی تھا کہ ناگاہ ایک یہ حادثہ بھی پیش آگیا۔مولانا کواس قدرسخت صدمہ ہے کہ انھوں نے لکھنا پڑھنا سب ترک کردیا ہے اور ان پرایک عالم گمشدگی طاری ہے۔ قارئین سے درخواست ہے کہ وہ مرحوم کے لیے دعائے مغفرت کریں اورمولانا کے لیے بھی دعا فرمائیں کہ اﷲ تعالیٰ انھیں صبر جمیل کی توفیق عطا فرمائے ۔
[عمید الرحمن عثمانی(منیجر)، اگست ۱۹۸۴ء]

 

أحمد شوقي: شاعر الأمراء في القرن الرابع عشر

Although the contribution of Ahmad Shoq┘ to Arabic literature, particularly to its poetry which is praised everywhere, which made him an authority and gained him the honor, yet there is a great contradiction between his fames and opposition; the fames accept him as lord of the poets while the opposition deny this status and title him as the poet of the lords. These contradictions made an unsatisfactory condition amongst the scholars about his personality and the contributions he added. The question is that; how much reality has the opinion of the denier? This article provides the evidences taken from his poetry and proves the realities about the blames raised by the opposition, and then solves the matter. It also makes a reader convinced to accept it, but not to forget the contribution made by this great poet of a great language with a huge literature.

Investigating the Role of Terazosin, an Alpha Adrenergic Agent in Acetaminophen Induced-Acute Liver Injury and Cyp2e1 Gene Expression

Liver is a principal organ that preserves the homeostasis of human body and performs many other functions including; detoxification of drugs, storing glycogen, regulating cholesterol and metabolism of urea. Liver injury induced by drugs is still a critical obstacle in the successful development of medicines. Acetaminophen (APAP) is an extensively consumed pain killer and is also the main cause of Drug Induced Liver Injury (DILI). An established biomarker for analyzing liver injury at molecular level is Cytochrome-P450 2E1 (CYP2E1) enzyme, mostly associated with the acetaminophen hepatotoxicity. Thus, a safer more reliable and economical way to deal with DILI is to determine an alternative use of the approved drugs. Binding of adrenergic ligands with their particular receptors is prevented by alpha-adrenergic blockers and is used in treating benign prostatic hyperplasia, cardiovascular disorders and erectile dysfunction. In this current proposal we have investigated whether terazosin (TER), an alpha adrenergic blocker, is effective as a hepatoprotective agent in an acetaminophen induced acute liver injury induced animal model. White New Zealand rabbits were used as animal models and were given an oral dose of acetaminophen to induce acute liver injury. It was observed that the Adenosine triphosphate (ALT) and Alkaline phosphatase (ALP) levels were much reduced by TER. ALT results showed statistical significance when compared with APAP alone. The serum ferritin level result was found to be decreased following the APAP intake. Lipid profile was much improved by TER as it decreased the level of Triglycerides (TG), Total Cholesterol (TC), Total Lipids (TL) and Low Density Lipoproteins (LDL) and increased the level of High Density Lipoproteins (HDL). TG level was statistically significant when comparing CON with both APAP and TER. Urea and creatinine level was also reduced indicating that TER acts as renal efficient agent. As CYP2E1 is upregulated during liver injury, it was observed that TER downregulated the expression level of CYP2E1. Hence, it can be stated that TER is not only safer for arterial hypertension but it is safe for human consumption. TER showed prevention of acute liver injury that was caused by acetaminophen, thus further studies can strengthen its alternative use in hepatoprotection.
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