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نواب حبیب اﷲ خان

نواب حبیب اﷲ خان
یہ سال مسلمان والیان ریاست کے لئے خاص طور سے اندوہناک ثابت ہوا، مرحومہ سرکاریہ بھوپال کے سانحہ وفات کے بعد ان کے پوتے حبیب اﷲ خان، رامپور کی اسلامی ریاست کے مسند نشین پھر نواب صاحب والی ٹونک کی وفات کے سانحے یکے بعد دیگر پیش آئے اور دنیا کے انقلابات کے نئے نئے نقشے آنکھوں کے سامنے پھرنے لگے، کل من علیھا فان ویبقی وجہ ربکّ ذوالجلال ولاکرام[الرحمن: ۲۶۔۲۷]، دعا ہے کہ اﷲ تعالیٰ مرنے والوں کو مغفرت اور ان کے جانشینوں کو توفیق حسن عمل عطا فرمائے۔ (سید سلیمان ندوی، جولائی ۱۹۳۰ء)

 

بینک اکاؤنٹس کی فقہی حیثیت اور کٹوتی زکوۃ [ایک تحقیقی جائزہ]

Zakat is one of the most important elements of Islam, which is obligatory upon every able-bodied Muslim after fulfilling the conditions of Zakat. In this regard, zakat payers either pay their zakat themselves or the government collects zakat from them through financial institutions, in which a large part is obtained through bank accounts, so four points need to be researched in this article. 1. The accounts of the people in the bank will be counted according to which type of assets? The preferable opinion in this is that the bank accounts will be counted among the internal assets.2. Does the government have the right to withdraw zakat from people's deposits in the bank or the owner of the property? The opinion of the majority of scholars is that it is obligatory to give Zakat to the government of the external assets, and the government has the authority to ask for Zakat regarding the internal assets 3. Are bank accounts like loans? In summary, the status of a bank account is similar to a debt, but a new type of debt. 4. Are all the conditions of Zakat observed in Pakistani banks regarding the deduction of Zakat or not? From the evidences, it has been concluded that there are six flaws in the method of zakat collection through banks. In this paper, Analytical research methodology is adopted. In this paper, the researcher has preferred to derive concepts from the primary sources related to the subject and later has used secondary sources and contemporary references so that the subject is embellished by the combination of ancient and modern views.

Pancreatic B-Cell Apoptosis, Insulin Secretion & Their Modulatory Mechanisms by Natural Compounds in Vitro & in Vivo

Insulin secretory dysfunction is major pathophysiology of diabetes which is aggravated by β-cell apoptosis. Metformin and sulfonylureas, two major oral hypoglycemic agents used for the treatment of diabetes, enhance insulin sensitivity and stimulate insulin secretion, respectively. Though some dipeptidyl peptidase-IV inhibitors are reported for β-cell protective activity; however, results are not conclusive yet. Therefore, taking advantage of our in house pure compounds library an attempt was made to identify compounds having β-cell protective as well as insulin secretory activity, and study their mechanism(s) at molecular and cellular levels. In order to evaluate the compounds for this dual activity, we used pancreatic β-cell line MIN6 cells to develop H2O2 mediated apoptosis and glucose stimulated insulin secretory assay systems. Out of 34 tested compounds, seven (7) compounds showed strong β-cell apoptosis inhibitory activity. Amongst them genestein (GS), quercetin (QCT), and cinnamic acid (CA) were evaluatedthrough triple channel immunostaining for mitochondria-actin-nuclei which revealed restoration of mitochondrial membrane potential, preservation of cytoarchitecture of cells and reduced nuclear condensation in MIN6 cells. Oxidative stress mediated activation of cleaved caspase 3 was undetectable in MIN6 cells after treatment with these compounds, further confirming the inhibition of mitochondria mediated apoptosis. Moreover, real time PCR study of mRNA expression showed that QCT and GS both downregulated the expression of apoptotic gene Casp9, and increased expression of both Ins1 and Ins2 genes. GS, QCT and CA also stimulated insulin secretion from MIN6 cells/ mice isolated islets. We found CA significantly inhibited nuclear condensation, decreased TUNEL positivity of pancreatic β-cells and preserved islets cytoarchitecture in Wistar rats. The effect of nicotinamide-cinnamic acid (NA-CA) was also studied in vivo, and we found that NA-CA significantly decreases β-cell apoptosis and induces insulin secretion than these agents alone. Immunohistochemical analysis of NA-CA pre-treated rat pancreas revealed decreased cleaved casp3 levels and increased phosphorylation of ERK½ in β-cells. Moreover, real time PCR anlaysis of NA-CA showed decrease in expression of Casp3 and Casp9 mRNA in MIN6 cells. This suggests that dual effect of NA-CA seems to be mediated via ERK½ signaling pathway and through modulating the mRNA expressions of apoptotic proteins. Intriguingly, we found orobol, tambulin and hispidulin as novel insulin secretagogues in the current study. TM enhanced insulin secretion in a dose dependent manner only at stimulatory glucose concentration in isolated mice islets. Pharmacological inhibition of protein kinase A and calcium channels significantly decreased insulin secretion induced by TM. This suggests that TM exerts an exclusive insulin secretory effect by modulating Ca2+ channels and PKA pathway. From the current study, some compounds with potent insulin secretory activity were identified. Interestingly few lead compounds having dual activity were also discovered. Taken together, these compounds may serve as lead compounds to be further studied for their anti-diabetic activity.
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