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خلاصة الكتاب

لقد تحدثتُ في ھذه الدراسة عن الأدب المقارن وبدایۃ الشعر الحر، وحقیقۃ الشعر الحر، وھل الشعر الحر نوعٌ من النثر؟ وھل کانت حرکۃ الشعر الحر قویۃ ام لا، ثم تحدثت عن بعض شعراء العصر الحديث، وإتفاق الشعراء حول نازک الملائکۃ، ومکانۃ نازک الملائکۃ بین الشاعرات (النساء) في عصرھا.

 ثم تحدثتُ عن الشعر الحديث في شبہ القارۃ الھندیۃ، وتکلمتُ عن الأدب النسائي، والشاعرات الباکستانیات في اللغات المختلفہ داخل باكستان، ثم الأدب النسائي في اللغۃ الأردیۃ، وأھم الشاعرات في اللغۃ الأردیۃ بعد قيام الباکستان، ثم الأدب النسائي والعھد الحاضر، وتکلمت عن الغزل و بروین شاکر، وأعطیتُ نبذۃ بسیطۃ عن بعض أشھر شعراء العصر الحديث، وعن دور النساء في الساحۃ الأدبیۃ والشعریۃ بصفۃ عامۃ، وعن دور نازک الملائکۃ وبروین شاکر بصفۃ خاصۃ، وأن لھما مکانتھما الخاصۃ في الساحۃ الأدبیۃ والشعریۃ، وأنھما مشترکتان في الأسلوب والرأي والأفکار والأحزان، وأنھما من مشجعي الشعر الحر، ولکنھما مختلفتان في اللغۃ والدُول والجنسیۃ والعمر والتجربۃ، وقد تناولتُ شخصیۃ نازک الملائکۃ منذ ولادتھا إلی وفاتھا، وأنھا تعتبر من أکبر شاعرات العرب في القرن العشرین، ولھا مکانۃ عظیمۃ في الساحۃ الأدبیۃ؛ حیث أنھا قامت بحرکۃ شعریۃ جدیدۃ (حرکۃ الشعر الحر)، وھي في نفس الوقت رائدۃ الشعر الحر، ثم تکلمتُ عن أسلوب کتابتھا، وأھم دواوینھا، وعن ممیزات أشعارھا، ثم تحدثت عن بدایۃ النظم عند نازک الملائکۃ، وإلی من تنسب ریادۃ الشعر الحر، ثم تکلمت عن الشاعرۃ المعروفۃ بروین شاکر منذ ولادتھا إلی وفاتھا، وأھم أعمالھا العلمیۃ والإجتماعیۃ والشعریۃ، وأھم دواوینھا والمجموعات الشعریۃ المعروفۃ لھا وأحزانھا وما إلى ذلك، وعن فکرتھا عن العشق وعالم الرجال ، ومکانتھا في الأدب الأردو، ثم تحدثتُ أخیراً عن الأشعار المتشابھۃ والمختلفۃ من قصائد نازك الملائکۃ وبروین شاکر، وھذا الجزء من الدراسة استغرق وقتاً أطول، وبذلتُ فیھا جھوداً أکبر، وذلك أنني قمتُ بترجمۃ بعض قصائد بروین شاکر، فشرحت ھذہ الأبیات، وشرحتُ قصائد نازك الملائکۃ بشکل مجمل بسیط مفھوم للقاريء ، ثم عقدتُ...

Memorization Without Comprehension: A Window onto the ‘Extremities’ of the Capability of Human Brain

Muslims across the world memorize the Quran in Arabic for verbatim recall. Memorizers can be native speakers of Arabic, non-native speakers of Arabic, or non-Arabic speakers. The purpose of this study is to investigate expert Quran memorizers on their memorization practices including what they brought to the act of memorization and what, according to them, underlay their success in memorization. Ten memorizers were interviewed about their reflections on their memorization practices. The analysis reveals that while some practices of the Quran memorizers are in line with findings from research literature on memory, there are others which are peculiar to them. The conclusion drawn is that Quran memorizers recite accurately because they do not learn the language. It is further concluded that Quran memorization is a special case, in which a range of extra linguistic factors such as identity, motivation and intention play an important role.

Formulation Development of Mucoadhesive Drug Delivery System for Milnacipran Hcl Using Design of Experiment Approach

Milnacipran HCl is a potential candidate to treat fibromyalgia associated with or without depression like comorbid conditions. The requirements of multiple dosing, absorption in first part of small intestine and fluctuating steady state plasma concentrations of drug have made it a suitable candidate for gastro-retentive sustained release drug delivery system. The utility of chitosan as mucoadhesive and polycaprolactone as hydrophobic polymer was aimed for creation of this matrix delivery system. Modified hot melt granulation with addition of second polymeric solution was opted for preparing optimized blends of acetaminophen. Modified wet granulation technique was utilized to prepare blends of milnacipran with different ratios of polymers. The optimized solutions for formulations containing blends of three polymers and drug with two solvents, i.e., dichloromethane and chloroform was optimized using design of experiment. A simple and sensitive colorimetric method for estimation of milnacipran was developed with ninhydrin to properly estimate drug from dissolution samples at 570 nm wavelength. The optimized blends were characterized for mucoadhesive time and strength using tensiometer, drug release analysis opting HCl buffer pH 1.2 for 12 h, kinetics of drug release and drug excipient compatibility analysis by utilizing FTIR and DSC. The optimized formulations M21-M24 were compared against reference formulation specifications for similarity index (f1 and f2). The optimized formulations were also scaled down containing 30 mg of drug according to weight of animals and were characterized for release parameters, i.e., the time to release certain percentage of drug (T10%-T90%). Different pharmacokinetic parameters were evaluated for M44 formulation using both non-compartment and two compartment model approaches. The best correlation (R2) values of 1 were observed with non-compartment model so parameters calculated were used to establish in-vitro in-vivo II correlation after estimating fractions of milnacipran absorbed/unabsorbed and time to absorb specific concentration of milnacipran using Wagner-Nelson method. The developed analytical method proved sensitive and precise with LOD and LOQ values of 0.55 and 1.667 μg/ml, respectively. Mucoadhesive strength was found as 201.06±16.8 dynes for different formulations with more than 12 h of adhesion time. Drug release studies showed release independent of concentration and was best described by Korsmeyer-Peppas model representing swelling controlled system. The n values of 0.5-0.7 showed dependency of release on both dissolution and diffusion mechanism. There were only physical interactions observed at various positions of IR spectrum with functional groups of polymers and drug were found intact. Thermal studies revealed that milnacipran has sharp melting point of 179.85℃ which was lowered to round about 154.30℃ due to covalent and ionic interactions required to form true blend with polymers. M24 formulation proved best on similarity parameters, i.e., f1=6.09, and f2=72.46, representing true similarity. Cmax, Tmax, and AUC0-∞ calculated for M54 were markedly found different from oral solution (P˂0.05) proving sustained delivery of milnacipran from the formulation blends. Bioavailability of M54 formulation was three fold improved as compared to solution. Level A correlation was established by comparing the above parameters and found R2 were 0.992, 0.9831 and 0.9998. The above results proved that milnacipran might be formulated as mucoadhesive DDS using three polymers opting design of experiment approach and evidenced best on IVIVC. III
Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

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