Search from the Journals, Articles, and Headings
Advanced Search (Beta)
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...

مولانا عبدالرشید نعمانی

مولانا محمد عبدالرشید نعمانی
اگست کے آخری عشرہ میں پاکستان سے یہ اندوہ ناک خبر آئی کہ مولانا محمد عبدالرشید نعمانی جے پوری کا کراچی میں انتقال ہوگیا، اناﷲ وانا الیہ راجعون۔
مولانا کی نظر دینی علوم تفسیر، حدیث اور رجال پر اچھی اور گہری تھی۔ ان کی تعلیمی زندگی کا کچھ زمانہ دارالعلوم ندوۃ العلماء لکھنؤ میں بھی بسر ہوا۔ ملک کی تقسیم سے پہلے اور بعد میں بھی ان کا تعلق ندوۃ المصنفین دہلی سے رہا۔ یہیں سے ان کی کتاب لغات القرآن شایع ہوئی جو ایک مفید قرآنی خدمت ہے، یہ حروف معجم پر مرتب کی گئی ہے اور چھ جلدوں میں مکمل ہوئی ہے۔ شروع کی چار جلدیں جو الف سے شروع ہو کر ع پر ختم ہوئی ہیں مولانا نعمانی کے قلم سے ہیں اور آخری دونوں جلدیں مولانا سید عبدالدائم جلالی نے مرتب کی ہیں، پہلی جلد کے شروع مولانا عبدالرشید نعمانی کا بسیط مقدمہ ہے جس میں کتاب کی نوعیت اور اس کی ترتیب میں ملحوظ رکھے جانے والے امور کے علاوہ اپنی محنت و جاں فشانی وغیرہ کا ذکر کیا ہے۔ دہلی میں قیام کے زمانے میں ماہنامہ برہان میں ان کے مضامین بھی شایع ہوئے۔
تقسیم کے چند برس بعد وہ کراچی میں متوطن ہوگئے تھے، یہاں انہوں نے امام ابن ماجہ پر جو عالمانہ و محققانہ کام انجام دیا وہ ان کا بڑا کارنامہ ہے، جس سے حدیث کا کوئی طالب علم مستغنی نہیں رہ سکتا، اردو میں ان کی کتاب ’’امام ابن ماجہ اور علم حدیث‘‘ اور عربی میں ’’ماتمس الیہ الحاجۃ لمن یطالع سنن ابن ماجہ‘‘ نور محمد اصح المطبع و کارخانہ تجارت کتب کراچی نے شایع کی۔ یہ دونوں تصانیف نہ صرف امام ابن ماجہ کے حالات و کمالات اور ان کی سنن کی خصوصیات کا مرقع ہیں بلکہ ان میں فن حدیث...

Digital Marketing and Creative Economy Theory in Economic Development During the Pandemic

Changes in the world require a company to make innovations that are necessary in order to survive the onslaught of other companies' innovations, especially similar companies. A new economic concept that focuses on information and creativity that relies on creative ideas and knowledge from human resources for the main production factors. Creative economynowadays it is increasingly being carried out by the people, especially the younger generation in country because they feel this is a profession that is suitable to be done. Information technology is also needed in the distribution, promotion and sales transaction processes so that the process runs more effectively and efficiently. The potential for the development of this industry is due to several factors, namely the development of information technology as the main factor develops rapidly, access to information centers via the internet is much easier, the social innovation process runs smoothly, each region has a unique local cultural potential and the openness of society to modern culture, there are sources of knowledge such as many campuses that are a source of quality human resources, have high creativity and innovation.

Biological Evaluation, Isolation and Characterization of Compounds from Fagonia Cretica L.

The research work presented in this thesis deals with the chemotherapeutic (antiproliferative) and cancer chemopreventive activity of a medicinal plant from Pakistan; Fagonia cretica L. (Zygophyllaceae), based on the traditional claims for its use in folklore medicine in the treatment of different types of cancers and inflammatory conditions. Through a bioactivity guided fractionation approach, the crude extract (FCC), resultant two organic fractions i.e. n-hexane and ethyl acetate (FCN and FCE, respectively) and an aqueous fraction (FCA) were tested for their anti-proliferative and cancer chemopreventive activity by employing different standard bioassays. In this investigation, it was demonstrated that F. cretica extract and fractions have antiproliferative activity towards human breast cancer cells and it can exert cancer chemopreventive effects via NFκB inhibition, iNOS inhibition and QR induction. The most potent fraction was ethyl acetate (FCE) fraction followed by n-hexane fraction (FCN) in this study. Six compounds in total (FCEE1, FCEK2, FCEK3, FCEM4, FCEN5 and FCNC6) were isolated from potent fractions of this medicinal plant using repeated flash column chromatography. Structural elucidation was carried out through a series of spectroscopic experiments (1-D and 2-D NMR). Among these six compounds, one compound (FCEE1) is a triterpene acid, two compounds (FCEK2 and FCEN5) belong to the triterpene saponin class, one compound FCEM4 belongs to steroidal saponin class and two compounds (FCEK3 and FCNC6) belong to phytosterol class of chemical compounds. All the isolated compounds have known structures but these are isolated from this plant species for the first time. All the compounds were evaluated for their anti-proliferative activity against breast cancer cell lines (MCF-7 and MDAMB- 231), non-tumorigenic breast epithelial cell line (MCF-10A) and cervical cancer cell line (HeLa) by using sulforhodamine B (SRB) assay. Cancer chemopreventive potential of compounds was also estimated in different bioassays i.e. TNF-α activated nuclear factor-kappa B (NFκB) assay, inhibition of lipopolysaccharide (LPS)- activated nitric oxide (NO) production in murine macrophage RAW 264.7 cells (iNOS) assay, Aromatase inhibition assay and Quinone reductase 1 (QR1) induction assay. A serial dilution of eight concentrations (0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 μM) for each compound was tested. xix Purified compounds were able to reduce cell viability significantly in two phenotypically different breast cancer cell lines (MCF-7 and MDA-MB-231). This activity was markedly reduced in normal mammary epithelial cells (MCF-10A) thus indicating selective toxicity between malignant and normal cells. Among compounds, in NFκB inhibition assay, FCEE1 showed maximum inhibition (IC50, 5.26 μM) while in iNOS inhibition assay, FCEM4 demonstrated best activity (IC50, 0.38 μM). For QR1 induction, FCNC6 was proved to be best compound (CD, 17.07 μM). None of the compounds were active in inhibiting aromatase enzyme. Compound FCEE1, a triterpene acid was the most potent compound in this study followed by FCEM4. Elucidation and characterization of the cytotoxic mechanism was undertaken by cell cycle status, apoptosis and expression of transcription factors and their targets i.e. p53, p21, Bax, γ-H2AX and FOXO3a. Pure compound treatment was able to induce a time and dose-dependent decrease on cell viability of two phenotypically different breast cancer cell lines (MCF-7 and MDA-MB-231), while demonstrating a markedly decreased cytotoxic effect of triterpene acid (FCEE1) and derivatives i.e. triterpene saponins (FCEK2 and FCEN5) on normal mammary epithelial cells (MCF-10A). Cell cycle arrest (expressed by sub-G1 peak) and apoptosis was induced in both MCF-7 and MDA-MB-231 cells. Overall all the purified compounds were more effective against estrogen receptor negative breast cancer (MDA-MB-231) cells. Loss of breast cancer cell viability is associated with induction of DNA double strand breaks which were detected in both cell lines by pure compounds’ treatment. In MCF-7 cells, expression of p53 by FCEE1 seems to induce upregulation of the CDK inhibitor, p21, and pro-apoptotic Bax. In current study, pure compounds’ treatment to human breast cancer cells induced double strand breaks to DNA associated with activation of DNA repair protein γ-H2AX. Compound FCEM4 treatment was able to induce FOXO3a expression in both MCF-7 and MDA-MB-231 cells. This suggests that activation of FOXO3a in the absence of functional p53 plays a vital role in induction of cytotoxicity. The results of this study suggest that FCEE1 is cytotoxic through p53 dependent as well as independent pathways while FCEM4 uses only p53 independent pathway.
Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.