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رام بابو سکسینہ

رام بابو سکسینہ
افسوس ہے دسمبر کے آخری ہفتہ میں جناب رام بابو سکسینہ کاحرکت قلب بند ہوجانے سے بحالت سفر اچانک انتقال ہوگیا۔ موصوف کو اردو زبان وادب کے ساتھ عشق تھااوروہ اس کا بڑا وسیع اورگہرا مطالعہ رکھتے تھے۔یہی وجہ ہے کہ ایک ذمہ دار سرکاری عہدہ کی چند درچند مصروفیتوں کے باوجود انھوں نے ادبِ اردو پرمتعدد ضخیم کتابیں اپنی یادگار چھوڑی ہیں۔ ان کی کتاب ’تاریخ ادبِ اردو‘ کو بڑی مقبولیت حاصل ہوئی، اس موضوع پر یہ کتاب اس پایہ کی ہے کہ ادبِ اردو کاکوئی طالب علم اس سے بے نیاز نہیں ہوسکتا۔اس کے علاوہ’’اردو کے انگریز شعرا‘‘ نامی کتاب انھوں نے بڑی تلاش وجستجواورمحنت سے مرتب کی تھی۔ایک کتاب حال میں ہی’’مرقع شعراء‘‘کے نام سے شائع ہوئی ہے۔سنا ہے کہ دو کتابوں کے مسودے ابھی اورباقی ہیں جو غیر مطبوعہ ہیں،موصوف اب دنیا میں نہیں لیکن اُن کے یہ شاندار ادبی کارنامے اُن کانام زندہ رکھیں گے۔
[جنوری۱۹۵۸ء]

 

محمود تيمور كمصلح اجتماعي

Born in 1894 in "Darb Sadah" of Cairo: Mehmood Taimur has attained a distinguished place in the world of literature. Besides writing literature, he has also written many essays/articles. He has highlighted social problems in his social essays and has become a social reformer. He has pinpointed the following social issues in these essays: (1) He has exposed the social ills like class distinction: sexual deprivation destitute and ignorance. (2) He has also acquainted the people about the causes of polygamy and divorce in the light of Shariat and rejects the contention with the solid argument that woman is a weak creature subjected to all kind of wrong treatment. Every person has a right to lead a peaceful life in this world and no one has the right to deprive him of this privilege except owing to some Islamic law. Most of the people were unaware of the rights of woman granted by Islam or they were not accepting them but Mehmood Taimur has presented all those rights in a beautiful way before society that is why on reading his social essays man reaches the conclusion that he was a social reformer.

Study of Xanthine Oxidase Inhibitory Potential of Natural Products Extracted from Medicinal Plants and Synthesized Benzothiazine Derivatives.

Present work consists of screening of Croton sparsiflorus (Euphorbiaceae), Laggera aurita (Asteraceae) and synthesized benzothiazine derivatives for their xanthine oxidase inhibitory potential. Extraction and bioassay guided isolation of Croton sparsiflorus resulted in the identification of eleven compounds. Three compounds were purified and identified as crotsparinine (8), crotsparine (9) and sparsiflorine (10). Sparsiflorine (10) was the most active XO inhibitor from Croton sparsiflorus with IC 50 value of 18.0 ± 0.4 μM followed by crotsparine (9) and crotsparinine (8). Twelve compounds were also identified from Laggera aurita but only two were purified and subjected to XO inhibition potential namely 2,4-di-tert-butylphenol (21) and 2,4-ditert-butyl-6-nitrophenol (22) with IC 50 values of 43.2 ± 1.9 μM and 40.2 ± 1.2 μM respectively. Both the isolated compounds from L. aurita inhibited XO strongly. Out of thirteen synthesized benzothiazine derivatives twelve contain 1,4- benzothiazine nucleus. This nucleus is quite familiar to natural products. These derivatives were characterized by EIMS, 1 H-nmr and XRD analysis as 2H-1,4- benzothiazin-3(4H)-one (24), 2H-1,4-benzothiazin-3(4H)-one 1,1-dioxide (25), ethyl 4- hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (27), (3-oxo-3,4-dihydro-2H- 1,4-benzothiazin-2 yl)acetic acid (28), ethyl (3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2- yl)acetate (29), ethyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-2-carboxylate (30), ethyl (1,1-dioxido-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetate (31), 2-(3-oxo-3,4- dihydro-2H-1,4-benzothiazin-2-yl)-N-phenylacetamide (32), N-cyclohexyl-2-(3-oxo-3,4- dihydro-2H-1,4-benzothiazin-2-yl)acetamide (33), 1-(3-methyl-4H-1,4-benzothiazin-2- yl) ethanone (34), ethyl 3-methyl-4H-1,4-benzothiazine-2-carboxylate (35), ethyl (2E)- 2H-1,4-benzothiazin-3(4H)-ylideneacetate (36) and 2-benzoyl-2H-1,4-benzothiazin- 3(4H)-one (37). They showed little to moderate XO inhibition potential with [(3-oxo-3,4- dihydro-2H-1,4-benzothiazin-2 yl)acetic acid (28) as the most active followed by 2H-1,4- benzothiazin-3(4H)-one (24)] { IC 50 values of 124.2 ± 13.9 μM and 212.7 ± 16.4 μM respectively }.
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