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ڈاکٹر عبدالحئی عارفی

ڈاکٹر عبدالحئی عارفی ؒ
مارچ ۱۹۸۶؁ءکی آخری تاریخوں میں ہم لوگ مولانا سید ابوالحسن ندوی کے ساتھ مدینہ منورہ میں تھے، تو ایک صاحب نے کراچی میں ڈاکٹر عبدالحئی کی رحلت کی خبر دی، جس کو سن کر سب ہی ملول اور افسردہ ہوئے، مولانا علی میاں نے تو فوراًتعزیت کا تار لکھوا کر کراچی بھجوایا۔ میری نظروں میں ڈاکٹر صاحب کا وہ چھریرا جسم، منور چہرہ اور مطہر آنکھیں گھومنے لگیں، جب ان کو ۱۹۴۴؁ء میں پہلی دفعہ جونپور میں دیکھا تھا، اس زمانہ میں استاذی المحترم حضرت مولانا سید سلیمان ندویؒ کے منجھلے داماد برادرم سید حسین وہاں ڈپٹی کلکٹر تھے، ان کے کرایہ کا مکان ٹھیک ڈاکٹر صاحب مرحوم کے وسیع اور کشادہ مکان کے سامنے تھا، وہیں حضرت سید صاحبؒ ان سے ملنے گئے ہوئے تھے، میں بھی وہاں دو چار روز کے لیے پہنچ گیا تھا، عصر کی نماز کے بعد حضرت سید صاحبؒ کی نشست ڈاکٹر صاحب مرحوم کے گھر پر ہوتی، دونوں حضرت مولانا اشرف علی تھانویؒ کے خلفاء میں تھے، ڈاکٹر صاحب مرحوم حضرت سید صاحبؒ سے تقریباً پندرہ سال چھوٹے تھے، اس لئے ان کے ملنے کا انداز بالکل خوردانہ اور عزیز انہ تھا، مگر جس روحانی رشتے میں دونوں منسلک تھے، ان میں لطف وکرم، مہر و محبت، اور یگانگت و موانست کی نکہت بیزی اور شامہ نوازی کے سوا اور کیا ہوسکتی تھی، یہ خاکسار بھی ان نشستوں میں شریک رہتا، اس کے تھوڑے دن پہلے حضرت تھانویؒ کے بڑے مشہور خلیفہ مولانا محمد عیسیٰؒ کی وفات جونپور ہی میں ہوئی تھی، اس موقع پر امداد غیبی سے حضرت تھانویؒ کے اور خلفائے مجازین جنازہ میں شرکت کی غرض سے جس محبت سے پہنچ گئے تھے، اس کا ذکر زیادہ تر ان نشستوں میں ہوتا کہ کس طرح ایک نے غسل دیا، دوسرے نے نماز جنازہ...

Pengaruh Kinerja Kepegawaian Dalam Administrasi Perkantoran

Penelitian ini bertujuan untuk mengetahui dan menganalisis hubungan pengaruh kinerja kepegewaian dalam administrasi perkantoran di kantor camat kecamatann Tuhemberua kabupaten Nias Utara. Populasi dalam penelitian ini adalah pegawai Kantor Camat Kecamatan Tuhemberua yang berjumlah 12 orang. Jenis data yang digunakan dalam penelitian ini adalah data primer. Teknik pengumpulan data dengan angket, wawancara, observasi, ujian (test) dokumentasi. Teknik analisis data dengan melakukan verifikasi data, pengelolaan angket, dan pengolahan data: (a). Uji validitas data, (b). Uji reliabilitas data, dan (c). Pengujian hipotesis. Dari hasil perhitungan koefisien korelasi diperoleh rhitung (rxy) = 0,834 jika dikonsultasikan pada tabel harga kritik r produk moment untuk interval kepercayaan 5% setelah di hitung rhitung = 0,834 > rtabel = 0,576. Berdasarkan regresi linear sederhana maka sumbangan kinerja kepegawaian terhadap administrasi perkantoran di Kantor Camat Gunungsitoli Tuhemberua 2,668. Dari perhitungan koefisien determinasi besarnya pengaruh variabel x terhadap variabel y di Kantor Camat Gunungsitoli Tuhemberua 69, 48%. Berdasarkan kriteria pengujian hipotesis ternyata Ha adanya pengaruh dan H0 tidak adanya pengaruh, sebab thitung = 7, 20 > rtabel = 2,160 sehingga dapat dinyatakan adanya pengaruh kinerja kepegawaian terhadap administrasi perkantoran pada kantor camat Tuhemberuaa kabupaten Nias Utara.

Synthesis, Characterization and Biological Studies of Some Novel Mannich Bases and Their Transition Metal Complexes.

The present study was carried to synthesize some novel Mannich bases and their transition metal complexes. The ligands were synthesized by condensing various aldehydes and amines with cyclopentanone and cyclohexanone in presence of calcium chloride as a catalyst. All the reactions were carried out by using ethanol as solvent. The progresses of the reactions were monitored with the help of TLC. The synthesized scaffolds were then complexed with various transition metal chlorides such as CuCl2, NiCl2, CoCl2, and FeCl2 to afford their respective complexes. FTIR, 1H NMR, 13C NMR, UV-Vis, TGA and MS techniques were used to characterize the ligands and their complexes. The AAS was applied to propose the geometries of the synthesized scaffolds by means of metal-ligand ratio. The synthesized compounds were analyzed for their antiurease as well as antibacterial potentials. The nature of SAR of synthesized scaffolds has been demonstrated using docking studies. Twenty one new scaffolds are synthesized and characterized. The compound (1) was derived by condensing 4-methoxybenzaldehyde and pyrrolidine with cyclohexanone in ethanol. One equivalent of calcium chloride was applied as a catalyst. Ice cold conditions are obeyed in the beginning of reaction .The further development of the reaction was carried out at 70-90 oC for about 1.5 hour followed by continuous stirring. The further stirring was continued for one hour at room temperature. TLC was applied as a monitoring tool for the progress of the reaction. The precipitation of the product was carried out by the addition of the 5% NaHCO3. The compound (1) was finally obtained by filtration and washing. The compound (2) was obtained by the condensation of 3, 4-dimethoxybenzaldehyde, pyrrolidine and Cyclohexanone in ethanol under the same conditions as applied for compound (1). The same strategy was applied for the production of compound (3). It was obtained by the condensation of 4fluorobenzaldehyde, aniline and cyclopentanone.The Mannich reaction of 3,4dimethoxybenzaldehyde, pyrrolidine and cyclopentanone in the presence of calcium chloride using ethanol as a solvent to produce a novel Mannich base (4). The same strategy was applied for the isolation of the above mentioned scaffolds, (2), (3) and (4) as for compound (1). The complexes of the synthesized ligands were obtained by their reaction with transition metal salts. The compound (5) was obtained by mixing of equimolar ethanolic solutions of (1) and copper (II) chloride followed by heating at 50 oC for 10 minutes. The constant stirring of contents for three hours at room temperature resulted in the precipitation of (5). Finally the compound (5) was obtained by evaporating the solvent and washing with distilled water. The compound (6), (7), and (8) were derived by reacting compound (1) with nickel (II) chloride, cobalt (II) chloride and iron (II) chloride respectively. The compounds (9), (10), (11) and (12) were synthesized by reacting copper (II) chloride, nickel (II) chloride, cobalt (II) chloride and iron (II) chloride with compound (2) respectively. The complexation of the compound (3) with copper (II) chloride, nickel (II) chloride, cobalt (II) chloride zinc (II) chloride and iron (II) chloride resulted in the production of compounds (13), (14), (15), (16) and (17) respectively. The compounds (18), (19), (20) and (21) were produced by the reaction of copper (II) chloride, nickel (II) chloride, cobalt (II) chloride and iron (II) chloride with compound (4). All the complexes were isolated in similar fashion as compound (5). All the synthesized scaffolds were examined for their antiurease potential. It was revealed that all synthesized analogs exhibit moderate to excellent antiurease character as compared to standard thiourea with IC50 value, 21.25± 0.15 µM. The potent antiurease potential was reflected by compound (3) with IC50 value (0.83± 0.002 µM) which was greater than standard. Similarly the compounds (19) with IC50 value 1.42 ± 0.003 µM, (6) with IC50 value 4.41±0.003, (8) with IC50 value 5.21±0.003 μM, (21) with IC50 value 5.41 ± 0.005 µM, (11) with IC50 value 5.82 ±0.007 μM, (4) with IC50 value 9.25 ± 0.002μM and (9) with IC50 value 16.87± 0.03 µM exhibit better antiurease potential even than standard thiourea with IC50 value, 21.25± 0.15 µM. The synthesized scaffolds were also evaluated for their bactericidal behavior in comparison with standard drug Gentamicin. The investigative data reveals that synthesized scaffolds exhibit moderate to good bactericidal potential.
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