Search from the Journals, Articles, and Headings
Advanced Search (Beta)
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...

ڈاکٹر احمد لاری

ڈاکٹر احمر لاری مرحوم
۲۸؍ فروری کو پروفیسر احمر لاری بیاسی برس کی عمر میں اپنے خالق حقیقی سے جاملے، اِناﷲ وَاِنا اِلَیہ رَاجِعُون۔ وہ گورکھپور یونیورسٹی کے شعبہ اردو سے تعلق رکھنے والے قابل اور محنتی استاد تھے جن سے ان کا شعبہ، ملک میں معروف ہوا اور وہ خود پروفیسر محمود الٰہی جیسے لائق ترین صدر شعبہ کی سرپرستی و رہنمائی میں ملک کے اچھے لکھنے والوں میں شمار ہوئے۔ بظاہر نجیف و نزار بیمار نظر آتے لیکن قلم بڑا توانا تھا۔ حسرت موہانی ان کی تحقیق کا مرکز رہے، ان کا تحقیقی مقالہ جوبعدمیں کتاب کی شکل میں شائع ہوا ان کی غیرمعمولی محنت سے اپنے موضوع پر اسی طرح مصدر و مرجع بن گیا جیسا خود ان کے ایک رفیق پروفیسر افغان اﷲ خاں مرحوم کا فراق پر مقالہ تھا، حسرت موہانی سے ان کا یہ تحقیقی تعلق، مستقل رشتے میں یوں بدلا کہ انہوں نے حسرت موہانی کے تذکرہ شعراء اور ارباب سخن کوبھی مرتب کرکے شائع کیا۔ ارباب سخن کا مقدمہ ان کی تنقیدی صلاحیت کا بڑا خوبصورت آئینہ ہے جس میں اردو تذکرہ نگاری کا انہوں نے جامع اختصار سے جائزہ لیا ہے۔
ان کی کتابوں میں گلدستۂ نازنیناں، نکات سخن، غالب اور غالبیات اور اردو تنقید کا ارتقاء، نام بھی آتے ہیں۔ انہوں نے مختصر تاریخ گورکھپور بھی مرتب کی۔ ان کا اصل قصبہ لار تھا لیکن انہوں نے پیمان وفا گورکھپور سے ایسا باندھا کہ بالآخر اسی کی خاک کا حصہ ہوئے۔ بیماری آزاری کے باوجود وہاں کی علمی و ادبی مجلسوں میں ضرور شریک ہوتے، پروفیسر افغان اﷲ خاں مرحوم کے بعد ان مجلسوں میں ان کے دم سے رونق تھی۔ افسوس ان کے جانے کے بعد ویرانی کا احساس اور زیادہ ہوگا کہ محض علم و ادب کا ایک شیدائی ہی نہیں ایک ملنسار، غمگسار...

ہبہ مشاع اور غیر مشاع میں قبضہ

The institution of ‘Gift’ (ہبہ) is common in every religion. Every religion promo-tes this practice, as it is a tool to create sense of love and affection between the giver and the receiver. Similarly, Islam encourages its followers to perform it from time to time and spread sense of love and affection. The holy Prophet (Peace and Mercy be upon him) not only ordered the believers of Islam to exchange gifts but also, he himself was habitual of distributing things among the Muslims as gifts. Here, in this article, this exercise of the ‘Gift’ is discussed. Firstly, its lexical and terminological meanings are mentioned and supported with verses of the holy Quran and the traditions of the holy Prophet (PBUH). Furthermore, its need and importance are given consideration. Secondly, kinds of the ‘Gift’ are specified, which are ‘Gift of existing things and non-existing things’. Then the existing things are divided into ‘Devisable and non-devisable items’. In the end the concept of possession in the ‘Gift’ is stated. Along with all this opinions of the five schools of thoughts i.e. Hanafi, Maliki, Shafai, Hanbali and Shia, and their basis regarding possession of the ‘Gift’ are presented.  

Application of Various Strategies to Enhance the Solubility and Bioavailability of Rosuvastatin Calcium

The term ‘solubility’ is defined as an excess amount of solute that can be incorporated in a given amount of solvent. Solubility of poorly water-soluble drugs is one of the most emerging issue associated with these drugs to form a suitable dosage form that will provide desired pharmacological response. Their low solubility causes elimination of most of the drug from body as such, and desired therapeutic levels are not achieved. In recent years, a large number of drugs have been developed, but nearly 70% of new drugs have poor water solubility. Major part of the human body is made up of water. Therefore, drugs must be having a certain aqueous solubility. The solubility of drugs ultimately has strong impact on their bioavailability. Rosuvastatin calcium (RST) belongs to the Biopharmaceutics Classification System class II having low solubility and high permeability. It is a poorly water-soluble 3-hydroxy-3-methyl glutaryl CoA (HMG- CoA) reductase inhibitor. Efforts have been made to enhance solubility of these drugs. Different techniques have been used to enhance solubility of these poorly water soluble drugs such as reduction in particle size to increase surface area, thus increasing the dissolution rate of drug, solubilization in surfactant systems, formation of water-soluble complexes, drug derivatization such as strong electrolyte salt forms that usually have higher dissolution rate, producing liquisolid formulations, manipulation of the solid state of a drug substance to enhance drug dissolution i.e. by decreasing crystallinity of the drug substance through formation of solid solutions, solid dispersion formulations. Polymers are major players in these formulations to enhance solubility e.g., chitosan, polyvinyl pyrolidone, polyvinyl alcohol, β-cyclodextrin, etc. β-Cyclodextrin is one of the most efficient polymer among all of these to work as a carrier for these drugs to enhance solubility. In present work, fast disintegrating tablets (FDT’s) of rosuvastatin calcium were prepared by using β-cyclodextrin as polymer along with different super disintegrants such as kyron T 134 and sodium starch glycolate and microparticles were prepared by using β- cyclodextrin as polymer to enhance solubility. Microparticles were prepared by using solvent evaporation (solid dispersions), kneeding technique (inclusion complexes) and XXIfree radical polymerization to prepare hydrogel microparticles. Prepared formulations were evaluated by Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Thermo Gravimetric Analysis (TGA), dissolution studies, powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), zeta size and zeta potential, transmission electron microscopy (TEM), and stability studies to confirm enhancement in solubility. FDT’s were further characterized by wetting time, wetting volume, disintegration time, dispersion time etc. Different in vitro kinetic models such as zero order, first order, Higuchi, and Korsmeyer–Peppas were applied to determine the release behavior of drug from prepared formulations. Results were also statistically analyzed by mean, one-way analysis of variance (ANOVA), and p value was determined to check significant results. Results of FTIR and DSC of prepared formulations had revealed that stable complex was formed between drug and polymer. SEM study of formulations had shown that small openings were present on their surfaces. These openings facilitated the penetration of water and rapid release of drug. From PXRD study it was observed that drug had changed from crystalline to amorphous form. Internal morphology of TEM images had shown that drug was present inside of FDT’s and microparticles. Zeta size and zeta potential studies confirmed that microparticles had micron size and net charge was neutral. Wetting time, wetting volume, disintegration time, dispersion time, water absorption ratio of FDT’s were 43±1.15-96±1.5 seconds, 80±0.5-22±1.50 seconds, 3±1.50-77±1.50 seconds, 29±0.58-57±0.58 seconds and 1.10±0.01-2.00±0.02, respectively. FDT’s and microparticles dissolution studies had shown that FDT’s released 91- 97% (p=0.025) of drug while inclusion complexes and solid dispersions released 71-92% (p=0.15) of drug and hydrogel microparticles released upto 92% of drug (p=0.02). In contrast to prepared formulations, drug released from commercially available tablets of Rosuvastatin calcium was very less (43%). Due to acidic nature of Rosuvastatin calcium drug was more soluble at higher pH value i.e., at 6.8 as compared to 1.2 pH. Hydrogel microparticles containing Acrylamido-2-methyl propane sulphonic acid (AMPS) as monomer had shown pH independent swelling and shown better release than methacrylic acid (MAA) containing hydrogel microparticles. AMPS containing hydrogel microparticles released drug at both pH values but it was better at 6.8 than 1.2. Solubility studies revealed that prepared formulations had greater solubility at 6.8 pH phosphate buffer, 1.2 pH HCl buffer and in pure water than alone drug. All three types of formulations had enhanced solubility of Rosuvastatin calcium but it was highest at 6.8 pH phosphate buffer. FDT’s enhanced solubility of Rosuvastatin calcium 7.42 folds in HCl buffer of 1.2 pH, while in phosphate buffer of 6.8 pH 11.71 folds and in pure water 9.05 folds solubility was enhanced. Microparticles prepared by solvent evaporation had enhanced solubility 3.32 folds, 8.54 folds and 5.86 folds at 1.2 pH, 6.8 pH and in pure water, respectively. Hydrogel microparticles prepared by AMPS had enhanced solubility 7.53 folds, 10.66 folds and 7.30 folds at 1.2 pH, 6.8 pH and in pure water, respectively. In case of hydrogel microparticles containing MAA had no greater impact on solubility of Rosuvastatin calcium (RST) at 1.2 pH, while these enhanced solubility upto 9.59 folds and 6.9 folds at pH 6.8 and in pure water. From findings it was observed that solubility of Rosuvastatin calcium was enhanced by using these techniques. Pharmacokinetic data had also depicted that C max and AUC 0-24 were also greater for prepared formulations in contrast to RST commercially available tablets. Elimination half-life of drug was reduced upto 4 hours in our formulations. Toxicology data also shown that no toxic effects were observed from hematological, biochemical and histological studies. From findings of this study it was concluded that solubility of Rosuvastatin calcium was successfully enhanced by using techniques. Prepared formulations were found stable during stability studies of 6 month period. Thus, we can conclude that solubility of BCS class drugs can be enhanced by using these techniques with improved bioavailability.
Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.