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روشن امکانات کی شاعرہ: فضا موسیٰ

روشن امکانات کی شاعرہ: فضا موسیٰ
ڈاکٹر رحمت علی شادؔ
ہجر اثاثہ رہ جائے گا درد خلاصہ رہ جائے گا
شعر نگر میں نام ہمارا اچھا خاصا رہ جائے گا
شہرِ فرید میں جنم لینے والی ایک نو عمر، دوسروں سے ذرا ہٹ کر سوچنے والی، عام لوگوں سے قدرے مختلف مگر سنجیدہ، ہونہار، باشعور اور روشن امکانات کی ابھرتی ہوئی شاعرہ فضاؔ موسیٰ پاک پتن کی شعری فضا میں ایک خوش گوار اور کیف پرور جھونکے سے کسی طرح کم نہیں ان کا تازہ شعری مجموعہ’’ فضا سے کہنا‘‘ منصہ شہود پر آنے کے لیے بے قرار ہے۔ ان کا کلام پڑھنے کے بعد راقم اس نتیجے پر پہنچا ہے کہ ان کی غزلیات کے کچھ مصرعے اور اشعار اپنے تیکھے پن، ندرتِ خیال، پختگی فکر ، داخلیت اور خارجیت سے بھرپور رومانوی انداز لیے چونکا دینے کے ساتھ ساتھ دعوتِ فکر دیتے ہوئے نظر آتے ہیں۔
فضاؔ موسیٰ عہدِ جدید کی ایک منفرد لب و لہجے کی حامل شاعرہ ہیں جنھوں نے بالکل تھوڑے عرصے میں اپنی ذہنی اپج سے پاک پتن کی ادبی فضا میں اپنی نمایاں انفرادیت اور اپنا شعری تشخص قائم کیا ہے۔رومانوی فضائوں میں فضا کی شاعری عشق و محبت کی داستان لیے اپنی تمام تر رعنائیوں اور لوازمات کے ساتھ جلوہ گر ہے۔ ان کی غزلیات میں محبت کے مختلف رنگ جا بجا بکھرے نظر آتے ہیں، کبھی کبھی یوں محسوس ہوتا ہے کہ وہ زندگی کے کئی رازوں سے آشنا ہیں اور اس طرح وہ اپنے باطنی احساسات و جذبات کو حقیقت کا روپ دینے پر قادر نظر آتی ہیں۔ عشق و محبت کے کئی کئی رنگ ان کے کلام کا جزو لا ینفک ہیں۔ محبت اور محبت کے رنگوں کے متعلق وہ لکھتی ہیں:
جینے کا سامان محبت گر بخشے مسکان محبت
ساتوں رنگ ہیں اس دنیا...

أمير الشعراء أحمد شوقي: نثره الفني ومنهجه

It is very clear that Ahmad shoqi was titled as king of modern Arabic poetry due to his unforgettable literary deeds towards it. Apart it all, his good struggle toward Arabic prose were ignored in his life, because of the prose was not his field to be tried in and it has its own experts. Some of these experts collected his prose and compiled it in a huge encyclopedia of his literary works named “al mosoa al shoqia” (الشوقية الموسوعة). This article also discussed his literary prosaic struggles, his methodology which he acquired and the deficiencies which were pointed out by critics. Adding more, the feature of the prose are also drawn in.

Synthesis and Characterization of Drug Loaded Biodegradable Nanoparticles for Enhanced Bio-Distribution

Glioblastoma multiform (GBM) and Non-small cell lung cancer (NSCLC) are most invasive and uniformly fatal type of brain and lung cancer respectively, with median survival of less than 20 months after diagnosis even with the most aggressive treatment that includes surgery, radiation, and systemic chemotherapy. Currently many chemotherapeutic anticancer drugs are being used in clinical trials which inhibit tumor growth by inhibiting certain pathways inside cancer cells. Luteolin and Ellipticine are plant derived compounds of potent antitumor activity, class of topoisomerase II inhibitor which intercalates with DNA and makes DNA adduct and kill cancer cells. Another class of drugs is polo-like kinase (PLK) inhibitors; among those BI-2536 is highly potent anticancer PLK inhibitor with IC50 of less than 0.9 nM is recently abandoned from phase II trials due to adverse neutropenic effects via systemic delivery. Major limitation of GBM chemotherapy is highly selective semipermeable blood brain barrier (BBB) which is comprises of brain microvascular endothelial cells connected by tight junctions. For NSCLC, chemothereutic approaches also have some limitations such as invasive nature and reoccurrence of disease.To enhance bioavailability of drug across BBB and mucus barrier, high dose of drugs is being used which enhances offsite toxicity risk. To reduce offsite toxicity and enhance bioavailability of these drugs biodegradable nanoparticles (<100 nm size) are being developed as carriers to increase high payload of drugs and release drugs in sustained manner thus reduce dose dependent toxicity. Based on previous reports, current project is designed to synthesize and characterize biodegradable nanoparticles for enhanced bio-distribution. First, different biological materials (lipids, Albumin and PLGA), already being used for nanoparticles (NPs) synthesis were optimized and screened to get 100nm sized nanoparticles with high payload of drugs. PLGA and BSA NPs were selected from all due to high payload of drug 5% of PLGA and (9.5%) in BSA compared to other NPs. Both PLGA-PEG and BSA NPs were further characterized to determine morphology and size using zetasizer, TEM. Release kinetics and in vitro anticancer activity of nanoparticles vs free drug was determined against GBM cell lines (F98, (9LL) and NSCLC cell lines (A549) using toxicity assays. Drug loaded NPs showed promising results, released drugs in sustained manner and retained their toxicity. For GBM, BSA formulations were further characterized for in vivo bio distribution in rats and mice brains tissues by convection enhanced delivery (CED) and systemic delivery using fluorescent and confocal microscope. Conventional Polystyrene (PS) and freshly PEGylated PS particles of 40-60nm size were used as standard.Data was analyzed using MATLAB and statistical softwares (GraphPad Prism and Kaleidagraph). Both empty and drug loaded BSA NPs showed highest ex-vivo and in vivo distributions compared to conventional PS-NPs. BSA NPs were successfully synthesized with high payload of both drugs which retained their activity and release drugs in sustained manner. BSA NPs further showed promising in vivo distribution results both locally and systemically compared to conventional particles of same characteristics already available in market.
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