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تاریخ کا سب سے بڑا جلسہ

تاریخ کا سب سے بڑا جلسہ

10اپریل 1986ء لاہور پاکستان کی تاریخ کا سب سے بڑا جلسہ اور استقبال جس میں 10لاکھ سے زائد افراد نے شرکت کی ۔لاہور ائیر پورٹ سے مینار تک چند منٹوں کا سفر گھنٹوں میں طے ہوا ۔ٹنوںکے حساب سے پھولوں کی پتیاں نچھا ور کی گئیں کہ لاہو ر کی سڑکیں سرخ ہو گئیں لاہور کے ہوٹلوں ریڑھی بانوں کے پاس کھانے پینے کی اشیاء ختم ہو گئی تھیں ۔عوام نے ایسا جلسہ پھر کبھی نہ دیکھا تھا اور یہ وڈیو آپ پہلی بار دیکھ رہے ہیں ۔(بشکریہ :اسلم خواجہ )

 

مستشرقین کے مصحفِ عثمانی پر شبہات کا تنقیدی مطالعہ: علامہ شمس الحق افغانیؒ کے افکار کی روشنی میں

مستشرقین کے مصحفِ عثمانی پر  شبہات کا تنقیدی مطالعہ: علامہ شمس الحق افغانیؒ کے افکار کی روشنی  میں Orientalists have paid much attention to the studies of Quran, in this regard the first target of Orientalists is Quranic Codification and its Historical position, for which they tried their best to object the Historical background of Mushaf -e Usmani and its validity. While Islamic History bears an ample testimony to the validity of this Manuscript, a general trend of the orientalists has been to question the validity of such a core Islamic ideal. Maulana Shamsulhaq Afghani was a famous and great scholar of subcontinent, belonged to District Charssada Khyber Pakhtunkhwa, who wrote critical evaluations on Orientalist’s Quranic objections.  He served on many important designations’ like ministry of Baluchistan Qalat, President of wifaq ul madaris al Arabia Pakistan, Vice Chancellor of Islamia University of Bahawalpur and member of Islamic ideology Council Pakistan. Among his contiribution there are works that deal with the criticism of the orientalists’ approaches to the study of Islam in general and Quran in particular. In his book”Uloom- ul- Quran” he criticize orientalist’s trends about the codification of Mushaf-e-Usmani. In this research paper some selected objections of orientalists related to the codification of Mushaf-e-Usmani, and their critical evaluation in the light of Shamsulhaq Afghani's Thoughts has been discussed.

Synthesis of Metal Based Derivatives of Sulfonamides and Their Biological Evaluation

The work presented in this thesis concerns the synthesis of various sulfonamide derived Schiff bases by the equimolar reaction of sulfonamides e.g., sulfamethazine, sulfadiazine, sulfathiazole, sulfanilamide, sulfamethaxazole, 4-(2-aminoethyl)benzene sulfonamide, 4- (methyl)benzenesulfonamide, sulfisoxazole and sulfaguanidine with the respective aldehydes such as 5-chlorosalicylaldehyde, 5-bromosalicylaldehyde and 2- hydroxynaphthaldehyde. The free amino group (NH2) of the sulfonamide moiety condense with the carbonyl (HC=O) group of aldehydes to achieve the target of twenty- one new sulfonamide derived Schiff base (L1)–(L21) compounds. The structures of newly synthesized sulfonamides were elucidated by their physical, spectral (IR, 1H and 13 C NMR and mass) and analytical (CHN analysis) data. X-ray diffraction studies on nine sulfonamides were carried out to confirm the structures of 4-(5-chloro-2- hydroxybenzylideneamino)-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide (L1), 4- [(E)-(5-chloro-2-hydroxybenzylidene)amino]benzenesulfonamide (L4), 4-{2-[(5-chloro- 2-hydroxybenzylidene)amino]ethyl}benzenesulfonamide (L6), 4-chloro-2-[(E)-({4-[N- (3,4-dimethylisoxazol-5-yl)sulfamoyl]phenyl}iminio)methyl]phenolate (L8), 4-[(5- bromo-2-hydroxybenzylidene)amino]-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfon amide-4-bromo-2-[(E)-({4-[(4,6-dimethyl-pyrimidin-2-yl)sulfamoyl]phenyl}iminio) methyl]phenolate (L10), 4-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]benzene sulfonamide (L13), 4-{[(E)-(5-bromo-2-hydroxyphenyl)methylidene]amino}-N-(5- methyl-1,2-oxazol-3-yl)benzenesulfonamide benzylidene)amino]ethyl}benzenesulfonamide (L14), 15 (L ) 4-{2-[(5-bromo-2-hydroxy and 4-bromo-2-((E)-{4-[(3,4- dimethylisoxazol-5-yl)sulfamoyl]phenyliminiomethyl)phenolate (L17). The synthesized sulfonamide derived Schiff base were used as ligands for complexation reaction with a number of metalloelements [Co(II), Ni(II), Cu(II) and Zn(II)] using in a molar ratio of L : M as 2 : 1. The nature of bonding and structure of all the metal(II) complexes have been deduced by their physical (conductivity, magnetic measurements), spectral (IR, 1H and 13 C NMR and electronic) and analytical (CHN analysis) data. The result of these studies revealed an octahedral geometry for all the metal(II) complexes. Due to amorphous nature of the metal(II) complexes, their crystals could not be formed for X-ray diffraction studies. In order to evaluate the biological role of these compounds and the effect of metalloelements on the nature of their biological activity, all the synthesized compounds were screened for their in vitro antibacterial, antifungal and cytotoxic activities against four Gram–negative (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa and Salmonella typhi) and two Gram–positive (Bacillus subtilis and Staphylococcus aureus) bacterial strains and against six fungal strains (Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata) using agar-well diffusion method. The result of these studies revealed that majority of the compounds showed significant (~80%) to moderate (~50%) antibacterial/antifungal activity. The activity however, was enhanced upon chelation/coordination with the metalloelements: some compounds, which were non- active, became active and moderate active became significantly active. Amongst all the compounds, the zinc(II) complexes showed the highest activity. The brine shrimp (Artemia salina) bioassay was also carried out to study in vitro cytotoxic activity. These studies revealed that several compounds displayed potent cytotoxic activity as LD50 in the range of 4.898 x 10-4 to 6.745 x 10-4 M/mL.
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