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سدرہ کا مکیں چومے سرکارؐ کے قدموں کو


سدرہ کا مکیں چومے سرکارؐ کے قدموں کو
جبریلِ امیں چومے سرکارؐ کے قدموں کو

سدرہ سے بھی آگے کی رفعت کو چھو آئے
جو خاک نشیں چومے سرکارؐ کے قدموں کو

آفاق بھی کیوں رہتے محروم سعادت سے
جب روئے زمیں چومے سرکارؐ کے قدموں کو

قبلہ کبھی اقصیٰ سے کعبہ نہیں ہو سکتا
جب تک نہ جبیں چومے سرکارؐ کے قدموں کو

سلمانؓ کی قسمت میں برسوں کی مسافت تھی
صدیقؓ وہیں چومے سرکارؐ کے قدموں کو

عرفانؔ کی پلکوں کی حسرت ہی رہی لیکن
طیبہ کی زمیں چومے سرکارؐ کے قدموں کو

غربت کے خاتمے میں قرض حسنہ کا کردار

Poverty is a global issue, particularly, related to the developing countries. The whole world is taking measures to eradicate it. People have different types of talent to earn money. Some are skilled, some have good entrepreneurship ideas and some others are good at manual work. We find that a great number of such skilled people are suffering from lack of resources in Pakistan and therefore not properly able to exert their skills to their utmost. Pakistan, being a developing country, is suffering from the issue of poverty. Many efforts were made for the alleviation of poverty during various regimes. Pakistan People’s Party introduced the Benazir Income Support Program. The same program has been maintained by the present Muslim League (Nawaz) government, due to its so-called utility. However, the fact is that its utility is not promising, as the meager amount given to the needy ones consumes in the daily expenditures and produces no lasting good. Contrary to this thesis of alms-giving, an anti-thesis is provided by the tradition of the Holy Prophet, Muhammad (S. A. W), which emphasizes the provision of interest-free loan. The loan without interest, can enable a person to run his or her business, according to his or her capacity and the person can become independent. The present paper explores the prospects that how interest-free loan is more effective in removing poverty than alms-giving on a regular basis by the government.

Synthesis and Applications of Piperazine, Bis-Indole Derivatives and Gold Nanoparticles of Thiolated Ligands

This dissertation has been divided into four chapters and each chapter has its own numbering of compounds and references. General introduction related to the importance of heterocycle based drugs, drug designing and value of lead molecules in drug designing. This research work describes synthesis and bioactivities of different class of heterocycles such as piperazine, bisindole analogs in search of important therapeutic agents and also includes functionalized gold nanoparticles for catalytic study. During this research study, a variety of piperazine, and bisindole analogs were synthesized and screened for enzyme inhibition studies (thymidine phosphorylase, urease, antioxidant, β-glucuronidase and α-glucosidase, anti-Leishmania). Functionalized gold nanoparticles were synthesized for modulating their catalytic ability. The results obtained from this study are encouraging which are discussed separately in the forthcoming chapters 1, 2, 3 and 4. In first chapter, piperazine analogues are studied. We have synthesized eighteen piperazine derivatives (1-18) and evaluated for thymidine phosphorylase, urease, antioxidant, b-glucuronidase and α-glucosidase activity. All analogues showed potent thymidine phosphorylase inhibitory potential with IC50 values ranging between 0.2 ± 0.01 to 42.20 ± 0.70 μM when compared with standard 7-Deazaxanthine (IC50 value of 38.68 ± 1.12 μM). Compound 17 was found to be the most active among the series while compound 18 was found to be the least active. All these analogues showed varying degree of urease, antioxidant, b-glucuronidase and α-glucosidase activity. xi In second chapter, bis-indole analogues are studied. We have synthesized twenty seven bis-indole analogues (1-27) and evaluate their anti-leishmanial, urease, antioxidant, and b-glucuronidase activity. All compounds showed outstanding anti-leishmanial inhibitory potential with IC50 values ranging from 0.7 ± 0.01 to 13.30 ± 0.50 μM respectively when compared with standard pentamidine with IC50 value of 7.20 ± 0.20 μM. All analogues showed greater potential than standard except 23 when compared with standard. All these compounds showed varying degree of urease, antioxidant, b-glucuronidase and α-glucosidase activity. In third chapter, functionalized gold nanoparticles are studied. We report the fabrication of a family of nanozymes comprised of bioorthogonal ruthenium catalysts inserted in the protective monolayer of gold nanoparticles. By introducing simple modifications to the functional groups at the surface of the nanozymes, we have demonstrated control over the kinetic mechanism of our system. Cationic nanozymes with hydrophobic surface functionalities tend to replicate the classical Michaelis Menten model, while those with polar groups display substrate inhibition behaviour, a key mechanism present in 20% of natural enzymes. The structural parameters described herein can be used for creating artificial nano-systems that mimic the complexity observed in cell machinery. In fourth chapter we discussed the different bioassay protocols in detail.
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Asian Research Index Whatsapp Chanel

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