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اردو تفسیر نگاری کا پس منظر اورتفہیم القرآن کی خصوصیات

              بر صغیر پاک و ہند میں اردو میں ترجمہ و تفاسیر کا آغاز سولھویں صدی عیسوی میں ہوا لیکن یہ متفرق سورتوں اور پاروں سے آگے نہ بڑھ سکا۔ اردو زبان میں سب سے پہلا تشریحی ترجمہ حکیم محمد شریف خان بن محمد اکمل خان(م۱۲۲۲ھ) نے لکھا۔ یہ ترجمہ شائع نہیں ہوا اور ان کے خاندان میں محفوظ ہے۔ ہندوستان میں پہلی اردو تفسیر، چراغ ابدی ہے جو مولوی عزیز اللہ ہمرنگ  اورنگ آبادی نے ۱۲۲۱ھ میں لکھی۔ یہ صرف تیسویں پارے کی تفسیر ہے۔ اسی طرح شاہ مراد اللہ انصاری سنبھلی کی تصنیف خدائی نعمت بہ معروف تفسیر مرادی بہت مقبول ہوئی۔ یہ بھی تیسویں پارے کی تفسیر ہے اور تین سو صفحات پر مشتمل ہے۔ یہ۱۱۸۵ھ میں مکمل ہوئی۔

              ہندوستان کے معروف محدث شاہ ولی اللہ کے فرزند شاہ رفیع الدین (م۱۲۳۲ھ۱۸۱۷ء )نے ۱۲۰۰ھ میں قرآن مجید کا ترجمہ لکھا جو کہ مختصر اور جامع لفظی ترجمہ ہے۔ شاہ رفیع الدین کے چھوٹے بھائی شاہ عبدالقادر (۱۲۳۰ھ، ۱۸۱۵ء ) نے ۱۲۰۵ھ میں موضح قرآن کے نام سے اردو زبان میں قرآن کا ترجمہ اور حواشی لکھے۔ شاہ صاحب کا یہ ترجمہ اپنے دور کے لحاظ سے بہترین ترجمہ ہے۔ اس میں عربی الفاظ کے مناسب ترین اردو اور ہندی مترادفات کو استعمال کیا گیا ہے۔ شاہ عبدالقادر کی اس تصنیف کو اردو زبان کی پہلی مکمل تفسیر قرار دیا جا سکتا ہے۔ سر سید احمد خان (۱۸۱۷ء۔ ۱۸۹۸ء)کی تفسیر"تفسیر القرآن" بدلتے ہوئے حالات کے تناظر میں خصوصی اہمیت رکھتی ہے۔ اس کی پہلی جلد ۱۸۸۰ء میں شائع ہوئی۔ سرسید احمد خان کا دور مسلمانوں کے انحطاط اور انگریزی غلبے کی وجہ سے کش مکش کا دور تھا۔ جدید تہذیب کے زیر اثر عقلیت پسندی اور قدیم روایات  سے انحراف کی کئی مثالیں سامنے آ رہی تھیں۔ اس عہد کی تفاسیر...

Origin of Earth: A Quranic Perspective

The modern scientific concepts were clearly envisioned in the Qur'an date back to 7th century, when observational facilities were not available, mathematical principles were not discovered, primary principles (quarks) and fundamental forces  i.e. Gravitational and electromagnetic were not identified. The word earth (أرْضَARD) appears 409 times in Quran. The number of verses in which the Earth is mentioned first is quite small, e.g. Sura 2, verse 29 and sura 20, verse 4, where a reference is made to "Him Who created the earth and the high heavens". On the other hand the numbers of verses where the Heavens are mentioned before the Earth are much larger e.g. Sura-l-araf (7), Verse 54; SuraYunus (10), verse 3; SuraQaf (50), verse 38; Sura l-Hadid (79), verses 27 to 33 etc. The Quran describes itself as a book of guidance. Sura l-Baqarah, verse (67)[i] states:  قَالَ أعُوْذُ بِاللهِ اأنْ أَکُوْنَ مِنَ الْجَاهِلِيْن He said, "I seek refuge in Allah from being among the ignorant."The Qur'an does not render a coordinated description of the Earth Creation. In lieu of a continuous story of creation, there are verses dispersed all over the Quran which deal with certain aspects of the Earth Creation. These scattered verses provide information on the sequential events marking its development with varying degrees of detail. The Quran referred toward at least five points which shed light on the creation of heaven and earth.  And these points are entirely confirmed by scientific facts.    

The Genetic Analysis of Retinal Dystrophies in Selected Pakistani Families

THE GENETIC ANALYSIS OF RETINAL DYSTROPHIES IN SELECTED PAKISTANI FAMILIES Retinal Dystrophies (RD) are the major cause of inherited blindness in Pakistan. The worldwide prevalence of RD is 1 in 3,000-5,000 individuals. There are 42 known loci and 154 genes that have been reported to be associated with RD. In Pakistan the percentage of recessive diseases are higher than dominant or X-linked disorders, which might be due to the high level of cousin marriages. Therefore the purpose of the present study was to determine the frequency of the mode of inheritance of RD in the Pakistani population and to evaluate the genetic basis of RD in a cohort of consanguineous families collected from different areas of Pakistan. To determine the inheritance pattern of RD in the Pakistani population, data about medical and family history of 80 families suffering from RD were collected from different areas of Pakistan. Homozygosity mapping was used to map the genetic defect in 23 RD families. The families were analyzed for homozygosity at the known arRP loci using highly informative microsatellite markers and were analyzed for homozygous chromosomal regions by genome-wide SNP microarrays. Known RD genes residing in homozygous regions were screened for mutations by sequence analysis. Identified mutations were analyzed in a cohort of 28 or 44 Pakistani RP probands and 100 ethnically matched control individuals by allele-specific PCR or restriction fragment length analysis. In the Pakistani families with RD that were studied, the occurrence of autosomal recessive, autosomal dominant and X-linked inheritance forms was found to be 87%, 6%, and 2% respectively while 3% families were with uncertain genetic mode of inheritance. We thus conclude that autosomal recessive forms of the disease are more frequent among RD patients in the Pakistani population compared to other populations of the world. Homozygosity mapping and candidate gene analysis resulted in the identification of seven novel mutations, including four in known arRP genes; one in CRB1, one in PDE6B, two in CNGB1 while one known mutation was identified in RHO. In addition one novel mutation was identified in GRKI causing Oguchi disease, two novel mutations, one in CNGA3 and CNGB3 were identified in patients suffering from achromatopsia. In addition to these novel mutations, a new arRP locus at chromosome 11 was identified in a large consanguineous family. The 7 iifamilies that excluded known arRP loci showed homozygosity at different chromosomal locations that needs to be further confirmed through microsatellite markers. The current genetic studies of RD was helpful in obtaining the correct diagnoses of RD families who had previously been clinically misdiagnosed and facilitated the provision of a clinical therapy for patients of achromatopsia. In addition genetic counseling was carried out in those areas of Pakistan where there is little awareness of inherited diseases.
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