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عبالرزاق جھرنا

عبدالرزاق جھرنا

7مئی جنرل ضیاء الحق کے مارشل لاء میں پاکستان پیپلز پارٹی کے سب سے پہلے پھا نسی پانے والے عبدالرزاق جھر نا شہید کی برسی ہے محترمہ بے نظیر بھٹو شہید عبدالرزاق جھرنا کے والدین اور چھوٹی بہن کے ساتھ تصویر۔ جب کوٹ لکھپت جیل ہمیں ملنے آئیں تو سب سے پہلے انہوں عبدالرزاق جھرنا کی پھانسی کا پوچھا ۔ہمارے ساتھی آصف بٹ نے جب بتا یا کہ وہ بہت بہادری سے پاکستان پیپلز پارٹی کے ترانے اور جیوے جیوے بھٹو جیوے کے نعرے لگاتے ہوئے پھانسی گھاٹ گیا تو محترمہ بے نظیر بھٹو شہید کی آنکھیں نم ہو گئیں ۔محترمہ بے نظیر بھٹو شہید کے بعد کیا کسی نے پھانسی پانے والے یا خود سوزیاں کر نے والوں کے لواحقین کی خبر لی میرا پارٹی قیادت سے ایک سوال ؟

 

Factors to Consider in Midwifery Care during Climacteric and Monopause Period

This study discusses the management of climacteric obstetrics and menopause. Menopause is the final feminine cycle or when the final monthly cycle happens, one of the mental viewpoints of changing self-concept amid menopause is unquestionably menopausal ladies ended up on edge around their bodies and frame self-concept approximately how their bodies are. The side effects experienced by ladies some time recently menopause cause the mother to be ill-equipped approximately physical and mental changes. To decrease this, ladies must get ready themselves both physically and mentally for menopause. Ladies who are going through menopause go through the primary stages counting premenopause, perimenopause, menopause, and postmenopause, and menopause for the most part happens in ladies matured 45-50 a long time.

A Novel Approach for Evaluation of Multivariate Individual Bioequivalence

In this dissertation, a multivariate generalization of the criterion used for testing individual bioequivalence is proposed. Although various approaches have been reported in the literature for multivariate equivalence, the majority of these contemplate simultaneous comparisons of only means in each dimension for multivariate equivalence region. Unlike previous approaches, our proposed criterion combines not only the comparison of means and variances but also the within-subject correlations into a single aggregate criterion. In fact, in this research two multivariate criteria for testing of individual bioequivalence have been developed. The first criterion is based on traces of variance-covariance matrices of test and reference formulation hence ignores the correlation among pharmacokinetic parameters. Hence, for this criterion, the consideration of extension from univariate to multivariate could be questionable. Therefore, another criterion has been developed which is unlike the previous one and it involves the correlation among pharmacokinetic parameters. Finally, thesecond criterion is proposed as a multivariate generalization for testing of individual bioequivalence which is an actual multivariate extension of univariate individual bioequivalence approved by Food and Drug Administration. The proposed method is also illustrated by testing individual bioequivalence on Food and Drug Administration dataset. The exact distribution of proposed criterion is hard to drive, therefore, the bootstrap method as recommended by Food and Drug Administration is proposed. The performance of proposed multivariate individual bioequivalence criterion has been evaluated through a simulation study. The size and power of testing for individual bioequivalence using proposed multivariate criterion are determined by varying mean differences, within-subject variances, sample sizes as well as within-subject correlations between pharmacokinetic parameters.
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