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فصل دوم: قرآن مجید میں آیاتِ استفہام کی نوعیت اور مقاصد

فصل دوم:قرآن مجید میں آیاتِ استفہام کی نوعیت اور مقاصد

قرآن مجید اللہ تعالیٰ کی آخری کتاب اور انسانیت کیلئے کتابِ ہدایت و نسخہ کیمیا ہے۔قرآن مجید انسانیت کیلئے کتابِ ہدایت ہونے کی وجہ سے مختلف اسالیب اور مناہج رکھتا ہے۔انسانوں کے فہم کیلئے اللہ تعالیٰ نے قرآن مجید میں مختلف انداز اپنائے ہیں۔یہ اسالیب مختلف ومنفرد ہیں ، نہ تو شعر ہے ، نہ مروجہ نثر اور نہ ہی مسجع کلام ،بلکہ یہ کلام کہیں چھوٹی چھوٹی آیات پر مشتمل ہے تو کہیں بڑی بڑی آیات سے عبارت ہے مگر ہرجگہ الفاظ کی رونق اور چمک دمک کے ساتھ ساتھ معانی کا ایک بحر بے کراں ٹھاٹھیں مارتا ہوا دکھائی دیتا ہے ۔اسی بناء پر فصحاء عرب کو اس کلام کی صنف متعین کرنے میں بے حد دشواری ہوئی۔ قرآن مجید میں بیان کردہ موضوعات مختلف ہیں جن میں احکام، شرائع ، امثال، قصص ،عبر،وعد وعیدمواعظ و تاریخ، تبشیر وتنذیر جیسے تمام پہلو بیان ہوئے ہیں، لہذا ہر ایک واقعہ اور حکم اپنی نوعیت اور حساسیت کے اعتبار سے مختلف انداز ا میں بیان کیا گیا ہے۔قرآن مجید کے اعجاز میں یہ بھی شامل ہےکہ وہ مخاطبین کی نفسیات اور حیثیات کے مطابق احکامات کو بیان کرتا ہے،ارشادِ ربانی ہے:

" وَنَزَّلْنَا عَلَيْكَ ٱلْكِتَابَ تِبْيَاناً لِّكُلِّ شَيْءٍ وَهُدًى وَرَحْمَةً وَبُشْرَىٰ لِلْمُسْلِمِينَ "[[1]]

"ہم نے یہ کتاب تم پر نازل کر دی ہے جو ہر چیز کی صاف صاف وضاحت کرنے والی ہے اور ہدایت و رحمت اور بشارت ہے اُن لوگوں کے لیے جنہوں نے سر تسلیم خم کر دیا ہے" ۔

قرآن کا مخاطب انسان ہے اور یہ اپنے مخاطب کو منفرد انداز سے خطاب کرتا ہے، قرآن مجید میں اللہ تعالیٰ کا انسان...

The Effect of Multi Channel Retailing, Cooperation Synergity and Accounting Information Systems on Business Development Strategies That Impact on Business

In this study the researchers chose the research object, namely a building material trading company in Sampit, Central Kalimantan named PT. Samudra Mas Group. The urgency of this study is to determine whether the multi-channel retailing variable, cooperation synergy and accounting information systems affect business development strategies and ultimately have an impact on company performance. This is to ensure the use of a business development strategy for the next 5 years. The study was conducted using respondents who are employees of PT. Samudra Mas Group, which has director positions to middle management and has the authority to make decisions in company operations. Respondents amounted to 70 people. This research measurement method using Smart PLS Professional 3.0. Pulling data by observation, interviews and distributing questionnaires. The results showed that multi-channel retailing, synergy of cooperation and accounting information systems significantly influence business development strategies. As well as a business development strategy to mediate multi-channel retailing that affects business performance.

Mutation Spectrum in Pakistani Patients With Inherited Metabolic Disorders

Inherited metabolic disorders constitute a diverse class of genetic diseases caused by impairment in biochemical processes because of defective enzymes or transporters consequent upon which compromised conversion of substrate into the product takes place. These disorders are manifested phenotypically with a wide overlapping spectrum of signs and symptoms that could either be due to accumulation of toxic upstream substrates, insufficient production of downstream products or abnormal alternative substrate metabolism. Biochemical and molecular investigations help in diagnosis of hereditary metabolic disorders and that if attempted early, could improve therapeutic outcome in some cases. The current study was performed to investigate the spectrum of genetic variants in Pakistani patients with inherited metabolic disorders. A cohort of sixty-eight patients was enrolled in the study from local hospitals. Twenty-five of these patients were diagnosed with inherited unconjugated hyperbilirubinemias, one with GM1 gangliosidosis, nineteen with various types of mucopolysaccharidoses (MPS), and twenty-three with Wilson’s disease. Genomic DNA samples of these patients were subjected to Sanger sequencing of respective genes. The identified variants were confirmed in families of the patients for segregation. Sequence analysis of UGT1A1 in twenty-five patients diagnosed with inherited unconjugated hyperbilirubinemias identified 16 different variants, six of which were novel. The c.622-625dupCAGC and c.1021C>T were the most frequently observed UGT1A1 variants. DNA sequencing of GLB1 in one patient diagnosed with GM1 gangliosidosis identified a novel homozygous 2-bp deletion c.881-882delAT (p.Tyr294Terfs) in exon 8. Among nineteen patients diagnosed with various types of mucopolysaccharidoses during the study period, MPS type I was the most prevalent phenotype. DNA sequencing of IDUA in MPS type I patients revealed a diverse spectrum of variants spanning the whole gene. A missense variant c.1469T>C (p.Leu490Pro) was the most common variant identified in five patients in homozygous condition. Mutations identified in other MPS types were all private mutations and include c.1006+1G>C, c.1165C>T in IDS, c.531+5G>A in NAGLU, c.902G>A, c.1175C>T, c.IVS4-1G>A in GALNS and c.511-512delGG in ARSB. DNA sequencing in a cohort of twenty-three Wilson’s disease patients identified a diverse spectrum of 18 ATP7B variants spanning over the whole gene. The mutation detection rate was 71.7% and seven of the identified variants were novel. The most frequently observed ATP7B variant was c.3809A>G followed by c.3182G>A. To our knowledge, this is the first comprehensive study of inherited metabolic disorders from Pakistan. It should be helpful in neonatal screening, improved genetic counseling, and prenatal diagnosis in the affected families.
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