مولانا محمد عارف سنبھلی
دارالعلوم ندوۃالعلما کے تفسیر و عقائد کے استاد مولانا محمد عارف سنبھلی ۹؍ جون ۲۰۰۶ء کو جمعہ کے دن دفعتہ وفات پاگئے، فجر کی نماز اور ضرورتوں سے فارغ ہونے کے بعد یکایک ان پر کپکپی طاری ہوئی، گھر والوں سے کچھ اڑھانے کے لیے کہا مگر چند ہی سکنڈ میں ان کی روح قفس عنصری سے پرواز کرگئی، اناﷲ وانا الیہ راجعون۔
وہ عرصے سے ندوۃالعلما میں درس و تدریس کی خدمت انجام دے رہے تھے اس سے پہلے دوسرے مدارس سے وابستہ تھے، ایک زمانے میں جامعۃ الرشاد اعظم گڑھ سے منسلک تھے اور دارالمصنفین کے کتب خانے سے استفادے کے لیے مولوی حبیب اﷲ رانچوی ندوی کے ساتھ یہاں آتے اور لوگوں سے ملنے جلنے کے بجائے سارا وقت مطالعہ میں گزارتے، مولوی حبیب اﷲ سے میرا تعلق پرانا تھا ان ہی کے ساتھ میرے پاس آجاتے مگر وہ کم آمیز تھے اس لیے زیادہ کھل کر باتیں نہیں کرتے، ندوہ میں تو بڑی چہل پہل تھی مگر وہاں بھی کسی سے بہت بے تکلف نہیں دیکھا، عصر بعد مولانا علی میاں کی مجلس میں ضرور شریک رہتے مگر دوسروں کی طرح بڑھ چڑھ کر باتیں نہ کرتے خاموشی سے بیٹھے رہتے۔
مولانا عارف صاحب کا مطالعہ وسیع تھا، قرآنیات، کلام و عقائد سے شغف تھا، تفسیر و قرآنیات سے مناسبت کی بنا پر اترپردیش اردو اکادمی نے مولانا عبدالماجد سمینار کے ان مقالات کی ایڈیٹنگ ان کو سپرد کی تھی جو مولانا کی تفسیر پر تھے، ان میں میرا بھی مضمون تھا، اتفاق سے میں ندوہ گیا تو مجھ کو اپنے گھر لے گئے اور کہنے لگے کہ آپ کا مضمون مجھے بہت پسند ہے اور میں چاہتا ہوں کہ پورا چھپے مگر اکادمی کے ذمہ داروں کا اصرار ہے کہ یہ طویل ہے، آپ آگئے ہیں تو اس...
Cancer is a multifactorial disease with genetic and environmental risk factors. Environmental factors may also be termed as modifiable risk factors and these contribute towards 35% of cancer related mortalities as reported by World Health Organization. Obesity is the leading risk factor in this regard, causing not only deaths due to cancer but also to many other diseases. Among different factors causing obesity, a major contributor is lack of physical activity. In this era of modern technology and digitalization, sedentary mode of life has become a part of life and is mostly unavoidable. At the same time, there is a rise in the incidence of cancer. In the olden times, people used to do all manual work, a lot of walk, exercise and had healthy life style. Such healthy life style may have prevented them from various diseases. Physical activity as a therapy on daily basis, is associated with a reduction in incidence of various carcinomas. It may improve overall wellbeing of healthy people as well as diseases persons from various ailments. As it is a common proverb that, “prevention is better than cure”, physical activity serves as a preventive measure for various diseases and also for fitness of normal healthy people. Although it is a known fact, yet planned population studies are required to provide evidence. Instead of unorganized physical activities, a structured physical activity may help in improvement of condition of cancer patients, prevention of cancer, cancer related deaths as well we quality of life. Healthcare providers should guide the patients in this regard. There is lack of awareness among physicians and mostly they don’t refer them to physical therapists. There is also lack of information regarding the implementation of the programs and regimens of physical exercises for different diseases and cancers. Physical therapists may guide the patients in terms of frequency, intensity, duration of exercises which may serve as a betterment of their condition.
Recent data from 1000 Genomes Project suggest that human genome has large number of variations. While some of the variations in human genome are tolerated others result in pathogenic consequences. Consanguinity increases the probability of inheriting the variants in homozygous state in children that result in abnormal phenotype. Familial disorders are relatively prevalent in Pakistani population where consanguineous marriages are common practice. In this study, 12 inbred families belonging to various regions of Pakistan and inheriting different genetic disorders were sampled for molecular genetics analysis. Three different mutant gene identification strategies namely STR mapping, SNP array and whole-exome sequencing were used, either separately or complementary to each other. Linkage analysis of candidate genes/loci was done by STR markers and SNP genotyping. Families linked to the candidate genes were Sanger sequenced to identify causal mutations. Families excluded to reported loci were subjected to whole exome sequencing and if required to CytoScan® HD array for copy number variation detection. A series of filtering steps were followed to narrow the spectrum of variations down to a single functional variant among the several thousand variations. This study reports on three novel and six reported mutations responsible for causing familial diseases. A novel mutation, each in a family with hyponychia, Cenani-Lenz syndrome and spastic paraplegia 3A was found. Additionally, evidence were found for polymorphic initiation codon (p:M1I) in RSPO4 gene and for autosomal recessive inheritance in spastic paraplegia 3A. Whole-exome sequencing technology was successfully applied for gene identification in autosomal recessive and autosomal dominant disorders. Specific diagnosis of; spastic paraplegia 3A, pseudoachondroplasia, generalized lipodystrophy using variants derived by exome sequencing suggest that it has a dual role of mutation identification in heterogeneous disorders as well as a diagnostic tool in clinically overlapping phenotypes. The findings of current investigations will set the basis for establishing carrier screening and prenatal diagnosis to control the disease as well as for the better understanding of disease pathways.