Search from the Journals, Articles, and Headings
Advanced Search (Beta)
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...

مولانا محمد اسمٰعیل نانا[جنوبی افریقا]

مولانا محمد اسمعٰیل نانا
افسوس ہے کہ گزشتہ ماہ رمضان میں جانسبرگ(جنوبی افریقہ)کے ایک جید عالم اورنہایت مخیر بزرگ مولانا محمد اسمعٰیل کاانتقال ہوگیا مرحوم اصل باشندہ ڈابہیل یاسملک ضلع سورت گجرات کے تھے۔ہم لوگ جب ڈابہیل پہنچے ہیں اس وقت مدرسہ میں متوسطان پڑھتے تھے۔ مفتی صاحب اورراقم الحروف دونوں کے اسباق میں پابندی سے شریک ہوتے اورصبح وشام کمرہ میں حاضر رہتے تھے۔ اس زمانہ میں گاندھی جی کی تحریک سول نافرمانی چل رہی تھی۔حکومت نے اس میں شریک ہونے والوں کی جائیدادیں ضبط کرکے ان کوفروخت کرنا شروع کیا تھا۔اس پرمولانا مفتی عتیق الرحمن صاحب عثمانی نے اپنا مشہور اورمعرکتہ الآرا فتوی دیا کہ ان جائیدادوں پرحکومت کاقبضہ ناجائز اورحرام ہے اس لیے کسی مسلمان کے لیے ایسی جائیداد کاخریدنا جائز نہیں ہے۔ اس فتوی سے ایوان حکومت میں زلزلہ آگیا اور فتوی ضبط کرلیا گیا۔ اس موقع پر مرحوم مولوی محمد اسمعٰیل نانانے بڑی جرأت مندی اور دلیری کاثبوت دیا، اس فتوے کاگجراتی زبان میں ترجمہ کیا،ہزاروں کی تعداد میں طبع کیا اور پھر راتوں رات خفیہ طورپر دورہ کرکے اسے ایک ایک مسلمان کے گھر پہنچایا۔مرحوم نے جو کچھ پڑھا تھا شوق،محنت اوردلچسپی سے پڑھا تھا، مطالعہ کے خوگر تھے۔اس لیے علمی استعداد پختہ تھی۔طبیعت کے شروع ہی سے نیک اوردین دار تھے۔فراغت کے بعد جنوبی افریقہ چلے گئے اور کاروبار شروع کیا تولکھ پتی بن گئے۔ نہایت مخیر اورسیرچشم تھے، عربی مدارس کی امداد بہت دل کھول کر کرتے تھے۔ کتنے ہی مولوی صاحبان اورحاجت مندوں کے مستقل ماہانہ وظائف انھوں نے مقرر کررکھے تھے۔بصرف زرِکثیر متعدد دینی کتابوں کااردو سے انگریزی میں ترجمہ کرایا اور بڑے اہتمام سے چھاپ کر انھیں شائع کیا۔ دیوبند اوراس کے علماء کے نام کے عاشق تھے۔ کئی سال سے فالج کے شدید مرض میں مبتلا تھے اورصاحب فراش ہوگئے تھے لیکن اس عالم میں...

”غض بصر“ کا اطلاقی پہلو قرآن و حدیث کی روشنی میں

In 20’ century, everywhere in the world there is Muslim majority playing importa nt role in world, because it was over served and counted that every fifth man is Muslim. It is also a challenges for non-Muslim who are master of worldtche European land is the land of modernization, there are about in million Muslims. In America there are also over a thousand marques and Islamic organizations. Islam is creating Islamic world in central Asia. After disintegration n of USSR iii DS state such as Kaz, akhstan, Kyrg yzstan, Uzf›ekistan, Turkmenistan and Tajikistan. In fact Islam ii iR second religion most predominate religion after catholic. In Britain ñfuifims are demanding Islamic education. The sfnmic society strength the powerful secufarism in capitalist’s work and trended society as modern. The Muslims are model of world they base on Eurocentric social, politest, economic and cultural premises, progress, modernizing, traditions, secularities, liberalism, humanity and freedom. The Islamic political and social society stand in 7" century, the y believe iii God and red Quran, Islam separated religion from politics and brought peace for all as secular. Muslim are present and living according the teaching of Islam and playing important role in international world politics or international relations. Furthermore, the wars, nationalism, nation, states and human rights in all Islam impact is very much concert The politics, economic, social concern as religion n terminology y or image, more ever universal issues such as social justice, local legitimating and defending the home land are lies on the Islamic politics. The interest in religion and culture are the important factors in international relations.

Activity Guided Synthesis and Sar Study of Flavonols As Nootropic Agents

Cognitive dysfunction or brain fog is a major public health concern of 21st century associated with many neuropsychiatric and neurodegenerative disorders like Alzheimer Disease (AD). Memory is the key function of brain where the neural circuitry necessary for memory and learning is present in hippocampus of the brain. Nootropic drugs help in boosting cognitive skills while amnestic drugs disturb memory and learning process. The potential pharmacological role of flavonoids with special emphasis on their nueroprotective and nootropic effects is still uneplored. In this connection, the current research study was planned to synthesize flavonols with substitution and were subjected to a series of tests to examine their antioxidant potentials, safety and enzyme inhibition, molecular docking, nootropic activity and their biomarker studies. A simple and convenient methodology for flavonol derivatives (OF1-OF12) was used to synthesize the flavonols from ketone and substituted benzaldehyde. Initially electronically and chemically different flavonol derivatives (OF1-OF6) were synthesized. OF1 being the parent flavonol has hydrogen on its para position. The OF2 (N,N-dimethyl, N(CH3)2, strong electron donating and activating ), OF3 (chlorine, Cl, halogen), OF4 (methyl group, CH3, slightly electron donating and slightly activating), OF5 (methoxy group, OCH3, strong electron donating and strong activating) and OF6 (trifluoromethyl, CF3, strong electron withdrawing and strong deactivating) were synthesized and characterized. Similarly, flavonol derivatives OF7 and OF8 by changing the position of methoxy group from para to ortho and meta position followed by synthesis of dimethoxy derivatives of flavonols (OF9-OF12) in order to see the effect of 2nd methoxy group. The flavonol derivatives (OF1-OF12) studied in the acute and sub acute toxicity at different dose levels in phases were safe and suggested to be virtually nontoxic. The molecular docking studies of different flavonol derivatives attested the in-vitro cholinesterase (acetylcholinesterase and butyrylcholinesterase) studies. The assessment of nootropic potentials of the selected synthetic flavonols (OF1-OF12) at the dose of 12.5, 25 and 50 mg/kg was done out by applying well established passive avoidance step through test, passive avoidance step down test and novel object recognition (NORT) assay models. At a dose of 12.5, 25 and 50 mg/kg, all the tested flavonol exhibited a significant (*P<0.05, **P<0.01, ***P<0.001, n=8) step through latency (STL) that are comparable to amnesic group (scopolamine treated). Among the different flavonol derivatives, OF5 and OF11 were found the most potent flavonols suggesting that methoxy group is important for activity. The OF5 has methoxy group (OCH3) at para position and OF11 has methoxy groups (OCH3) at ortho and para position which is strong electron donating and activating group. In the passive avoidance step down test, the step down latency and in NORT, the percent discrimination index DI was also significant when mice were treated with flavonols (OF1-OF12) and tested against these models. In addition, it showed that synthetic flavonols (OF1-OF12) is decreasing the acetyl cholinesterase activity while also increasing the acetylcholine levels in the brain of test animals. The synthetic flavonols (OF1-OF12) significantly increased antioxidant enzyme activities (SOD, GSH and CAT) and reduced lipid peroxidation (MDA level) in the frontal cortex and hippocampus of brain. Pretreatment of mice with synthetic flavonols (OF1-OF12) produced significant change in SOD activity (2.94 to 2.25 folds) in the hippocampus and frontal cortex when compared with scopolamine treated (amnesic) group. Moreover, treatment of OF5 and OF11 significantly increased (P< 0.001) SOD activity by 2.82 (29.83±2.01, n=8) and 2.94 (31.07±1.92, n=8) folds compared to amnesic group. Moreover, the pretreatment of mice treated with 50 mg/kg of synthetic flavonols (OF1- OF12) significantly increased catalase levels in the hippocampus (4.06 to 2.93 folds) and frontal cortex (3.35 to 2.65 folds) when compared to amnesic. The synthetic flavonols (OF1-OF12) prevented scopolamine-induced elevation in MDA level as indicated by significantly (P<0.05, P<0.01, P<0.001, n=8) less MDA level in mice brain regions (hippocampus and cortex). There was significant rise (P<0.05, P<0.01 and P<0.001) in level of GSH in brain regions (hippocampus 3.66 to 3.44 folds and frontal cortex 3.22 to 2.73 folds) of group treated with synthetic flavonols (OF1-OF12) in comparison to scopolamine group. In short, the correlation of in-vitro study, in-vivo and ex-vivo animal study of synthetic flavonols (OF1-OF12) at the dose of 12.5, 25 and 50 mg/kg significantly improved the memory of mice and reversed the amnesic response induced by scopolamine.
Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.