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۔ مراتب اخترکا توقیت نامہ

مراتب اختر کا توقیت نامہ

                ساہیوال کی دھرتی جہاں اس بات پہ نازاں ہے کہ مولانا عطا اللّٰہ جنون، مولانا عزیز الدین عظامی، حفیظ جالندھری، مجید امجد، منیر نیازی اور گوہر ہوشیارپوری جیسے نامور شعراء نے یہاں قیام کیا وہاں حاجی بشیر احمد بشیر، ناصر شہزاد، جعفر شیرازی، احسن شیرازی اور یٰسین قدرت کے علاوہ مراتب علی اختر کو بھی اسی دھرتی نے جنم دیا۔

                سید مراتب علی اختر8مئی 1940کو پیدا ہوئے۔ چار بھائیوں اور پانچ بہنوں میں ساتویں نمبر پر آتے تھے۔ ایک بہن اور ایک بھائی آپ سے چھوٹے تھے۔میونسپل کمیٹی پرائمری سکول ایف برانچ سے ابتدئی تعلیم حاصل کی اور میٹرک کا امتحان گورنمنٹ ہائی سکول ساہیوال سے پاس کیا۔ آپ کی تاریخ پیدائش کے حوالہ سے اختلاف پایا جاتا ہے۔ آپ کے چھوٹے بھائی سیّد افضال حسین گیلانی لکھتے ہیں:۔

ہم دونوں بھائیوں کی عمروں کا درمیانی وقفہ صرف چار سال کا تھا۔ گھرمیں ہم اوپر تلے کے بھائی گنے جاتے تھے۔ غور کیجئے بھلا بڑائی چھوٹائی کا یہ کوئی اتنا بڑا فرق ہے؟ یہ عمریں تو ہم جولیوں اور لنگوٹیے یاروں کی ہوتی ہیں۔ لیکن۔۔۔ حسبِ مراتب وہ اول دن ہی سے ’’بہت بڑے ‘‘ اور میں بہت چھوٹا تھا۔

امی حضور سے سنا تھا کہ جب بھائی جان چھ ماہ کے تھے تو انتہائی نحیف اور دبلے پتلے تھے۔ آپ کو حضرت بابا جی صوفی احمد شاہ صابر علیہ الرحمت کی خدمت میں پیش کیا گیا جو میرے نانا کے چھوٹے بھائی تھے اور خاندان بھر کے مرشد تھے۔ بلکہ گیلانی سادات کے مقتدر گھرانوں کے پیروپیشواتھے۔ اللّٰہ کے سچے اور مقبول بندے تھے۔ آپ نے بچے کی کمزوری اور ناتوانی کو دیکھتے ہوئے تبسم فرمایا۔ دم کیا اور پھر زیر لب گویا ہوئے۔ ’اس...

آزاد تجارت کے فوائد و نقصانات

On the one hand Islam espouses the notion of free trade, and on the other hand it frowns on state interference in trade. Developed and developing countries make head way freely in a free trading culture. This state of affairs buoys up the spirits of traders and inspires them to invest freely and lead to an economic upturn. Thus society flourishes. Foreign direct investment flows in a country from free trade. The scientificand technical expertise of industrialized countries is transferred to low income countries. Not only high quality products are available in abundance in the open market but also the moderation of prices is automatically established by the competition of business people. In this way, the free trading culture functions as a filtering device in the free market and,  without any artificial or external interference, discharges all the tasks efficiently from its own internal logic. Critics of free trade, on the other hand, demur the system fills the coffers of multinational corporations but suppresses the rights of workers,  locals and small industrialists. The real purpose of this system is to establish Western powers’ control over global resources. Taking advantage of the flexibility of the free trading culture,  traders artificially raise prices through monopoly and hoarding.

Solid Lipid Nanoparticles for Thermoresponsive Drug Delivery: Fabrication and Evaluation

Thermoresponsive drug delivery systems (DDS) are designed for the controlled and targeted release of therapeutic payload by exploiting the hyperthermic temperature (>39°C), which may be applied by some external means or an encountered symptom in inflammatory diseases such as cancer, arthritis etc. However, available thermoresponsive DDS, including liposomes, have complex method of preparation involving toxic solvents and reagents. Recently, we have shown for the first time that melting point of solid lipid nanoparticles (SLN) can be optimized for thermoresponsive drug release by tuning their melting point (MP). The objective of this study was to provide some strong evidence in support of hypothesis that thermoresponsive solid lipid nanoparticles (TSLN) undergo solid-liquid phase transition at their melting point (>39ºC) leading to faster drug release. Thermoresponsive lipid mixtures (TLM) were prepared by mixing solid (lauric, myristic, palmitic and stearic acid) and liquid (oleic and linoleic acid) natural fatty acids in different ratios (0.1:1 to 1:2) and melting point was measured by differential scanning calorimetry (DSC). A graph was plotted between liquid content in TLM and the MP, and TLM that would melt at 39°C were identified by using straight line equation of the graph. The solidliquid phase transition was assessed by determination of temperature dependent change in viscosity (low at 39°C) and light transmission (higher at 39°C) that are characteristic of liquids. TSLN containing a chemotherapeutic drug, either hydrophilic 5-fluorouracil (5-FU) or lipophilic paclitaxel, were synthesized by hot melt encapsulation method. It should be noted that the TLM and the TSLN were made by physical interaction of materials and no chemical reaction was needed. The TSLN showed desirable spherical shape (TEM), size (100-300 nm), physicochemical stability (FTIR analysis), high yield (>85%) and encapsulation efficinecy (5-FU >40% and paclitaxel >90%). In 5-FU loaded TSLN, drug release studies were first performed by USP type II dissolution apparatus in PBS (7.4) at 37°C and 39°C. A sustained release pattern was observed at 37°C and 22-34% 5-FU was released in 5 hrs. On the other hand, >90% drug was released at 39°C suggesting that the SLN show thermoresponsive drug release in agreement with our hypothesis. Drug release from SLN at 39°C was similar to model oleic acid and linoleic acid nanoemulsions which further supports our hypothesis. Next, a quick and real-time differential pulse voltammetry (DPV) based electrochemical chemical detection method was developed using a graphite electrode to detect change in current with 5-FU concentration while increasing voltage was applied on reference and counter electrodes. This method also showed that sustained release pattern of 5-FU at 37°C was converted to an immediate drug release when heated to 39°C, thus, confirming the thermoresponsive drug release. In case of paclitaxel loaded TSLN, drug release was minimum at 37°C and 70-100% drug release achieved after 60 hrs. On the other hand, whole drug was released in 4-7 hours at 39°C. This 15-20 time higher drug release at hyperthermic conditions confirmed the thermoresponsive drug release from the TSLN. Blank SLN were found to be biocompatible with human gingival fibroblast cells (PCS- 201-108) although and breast cancer cells (MDA-MB-231). However, 5-FU loaded SLN showed some cytotoxicity after 24 hours which was due to the release of drug. 5-FU loaded SLN showed thermoresponsive cytotoxicity to breast cancer cells (MDA-MB-231) as cytotoxicity was higher at 39°C (22-28%) compared to 37°C (<10%) within 1 hour. Similarly, paclitaxel loaded TSLN showed higher cytotoxicity to glioblastoma cells at 39°C (31% cell viability after one hour) compared to 37°C (18% cell viability). The higher cytotoxicity at 39°C was due to the higher drug release. Finally, the TSLN were evaluated for brain targeting across blood brain barrier (BBB) and an in vitro BBB model was used consisting astrocytes (CRL-2541) and endothelial cells (b.End3). The BBB model was optimized at 39°C for 1 hour duration due to retention of semipermeable nature and lack of paclitaxel and heat related toxicity. The TSLN showed higher permeability across BBB at 39°C which may be attributed to the deformable liquid state that squeezes through the tight junctions of BBB without any damaging effects. In conclusion, the novel TSLN reported in this thesis may serve as safe and effective platform of thermoresponsive targeting of cancer.
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