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مولانا حکیم سید عبدالحئی

مولانا حکیم سید عبدالحیٔ صاحب

ناظم ندوۃ العلماء

            چند مہینوں سے معارف کا پہلا صفحہ علم و فن کے بزرگوں پر ماتم کے لئے مخصوص ہوگیا ہے، آج ہم دوسروں پر ماتم کرتے ہیں، کل دوسرے ہمارا ماتم کریں گے، دنیا کی یہ بزم ماتم اس فانی کائنات کے وجود کے ساتھ قائم ہے اور اسی کے ساتھ قائم رہے گی۔ یہ حوادث آباد عالم جس کو ہم تم قائم مستمر اور مسلسل جان رہے ہیں، ہر آن و ہر لمحہ اس طرح بدل رہا ہے کہ غور سے دیکھو تو معلوم ہوگا کہ جو نقشہ، جو کیفیت، جو صورت حال اس آن ہے وہ اس آن نہیں، ایک مستمر تغیر اور ایک مسلسل انقلاب جاری ہے اور پردہ دار کُلَّ یَوْمٍ ھُوَفیْ شَاَنٍ [الرحمن: ۲۹](ہر روز ایک نئے رنگ میں جلوہ گر ہے) لیکن باانیں ہمہ انقلاب و تغیر بظاہر اس کے قیام، استمرار اور تسلسل میں فرق نہیں آتا، سمندر کی لہریں ہر آن بدل رہی ہیں، مگر سمندر کی صورت میں کوئی فرق پیدا نہیں ہوتا، صورتیں مٹتی جاتی ہیں، شکلیں فنا ہوتی جاتی ہیں، مگر اس آئینہ خانہ کی آبادی اور صورت گری میں کوئی فرق نہیں آتا۔

خدا جانے یہ دنیا جلوہ گاہِ ناز ہے کس کی

ہزاروں اٹھ گئے رونق وہی باقی ہے مجلس کی!

            دوسری فروری ۱۹۲۳؁ء کی شام کو اس مجلس کا جو ممبر اٹھا ہے، اس کا اس دنیا میں مجازی نام عبدالحئی تھا، مولانا حکیم سید عبدالحئی صاحب ناظم ندوۃ العلماء جدید کے اولین علماء تھے سادات رائے بریلی کے مشہور خانوادۂ علم و عمل سے تھے، جس کے بعض افراد سلاطین کے درباروں میں اور بعض فقر و تصوف کی خانقاہوں میں ممتاز تھے، بعض درس و تدریس کی...

THE PHILOSOPHY OF CONTEMPORARY EDUCATION AND ITS IMPLICATIONS FOR THE DEVELOPMENT OF ISLAMIC EDUCATION

The title of this research is Theoretical Debate over the Philosophical Roots of Contemporary Education and Its Implications for the Development of Islamic Education. The purpose is to disentangle, to explore and to discuss the foundations of theoretical roots of educational philosophy and its relational consequences with Islamic education. The issues raised are: 1). How is the philosophical foundation of education and its relationship to philosophy and education? 2). What are the Philosophical Roots of Educational Theory and Its Implications for Curriculum, Teaching and Learning? 3). What are the implications for the development of Islamic education? The type of research is Library Research which uses philosophical and pedagogical approach, with descriptive method. The findings of this study are: a) the study of the key philosophical ideas that influence thought and development of education are aspects of metaphysics, epistemology and axiology. Without these three philosophical foundations, science and its various disciplines will fail; b) the relationship between philosophy and education are like two sides of one coin that cannot be separated, both give and take in the context of mutualism. So the existence of philosophy in education is a necessity; c) The theoretical debate over the roots of the philosophy of education requires the development of Islamic education.

Assessment of Biological Properties of Bone Marrow Mesenchymal Stromal Cell by Ex-Vivo Expansion and Differentiation

Mesenchymal stromal cells (MSCs) represent a rare population of multipotent stem cells found in many adult tissues. In bone marrow MSCs support haematopoiesis by providing marrow stroma. MSCs have recently emerged as an exciting candidate for cellular therapy due to their hypoimmunogenic properties and ability to differentiate into different tissue types. With the intent of optimizing large-scale expansion of MSCs for clinical use, we compared different culturing conditions for their ability to support growth and proliferation of bone marrow MSCs (BM-MSCs). We evaluated cells cultured in Alpha Modified Eagle Medium (αMEM), Dulbecco’s modified Eagle medium (DMEM) in the presence of either 10% fetal bovine serum (10% FBS), 10% pooled human platelet lysate (10% pHPL) or commercial serum-free formulation (StemPRO® MSC SFM). We concluded that supplementing growth medium with pHPL resulted in superior cell yield than fetal bovine serum (FBS) and comparable to commercial serum-free formulation. Study II was a phase-I human clinical trial, establishing safety of autologous BM-MSC transplantation in nine spinal cord injury patients. For this ex vivo expanded MSCs were injected intrathecally after premedication. All of our patients tolerated the procedure well and no complication was observed during a median follow up of 644 days. Some of the patients with sub-acute disease reported subjective improvement in sensory and neurological functions. Lastly we carried out a phase-I/II trial of MSCs in allogeneic use as a treatment option in treating steroid-resistant graft versus host disease (GVHD). GVHD is a life threatening complication of allogeneic stem cell xii transplantation and only a fraction of patients are cured through steroids. Those who fail to respond to steroid have a very poor prognosis. The patients received third party BM MSCs as their bone marrow MSCs were failing to cope with the immunemediated tissue destruction by donor T cells. A total of 33 MSC infusions were given to 10 patients suffering from acute GVHD (n=3), chronic GVHD (n=5) and overlap syndrome (n=2). Eight out of ten patients are alive after a median follow up of 11 months with five having sustained CR. Three patients with partial response received further doses to sustain response. One of them died of lung infection while others are still alive. One out of the two non-responding patients died after 17 days of MSC therapy due to advanced liver GVHD while the other is having stable disease course. The overall and disease-free survival was 80% and 50% respectively. The patients developed no complication or toxicity related to MSC infusion. Luminex analysis revealed a modest drop after MSC infusion in pro-inflammatory cytokines like IFNγ, TNFα, IL-1β, IL-2, IL-4, IL-6, IL-17A and IL-17F, whereas serum IL-10 levels were slightly raised. Overall a total of 57 preparations of cultured stem cells were made which were transplanted via I.V. or I.T. route with no adverse event or serious complication to report. Therefore it is concluded that MSCs can be safely given in both autologous as well as allogeneic setting as cellular therapy in selected clinical situations. This initial data on safety and efficacy calls for taking these clinical trials into advanced phase with more detailed account of efficacy measures and addition of placebo groups.
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