Search from the Journals, Articles, and Headings
Advanced Search (Beta)
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...

مولوی محمد اسمٰعیل میرٹھی

مولوی محمد اسمٰعیل میرٹھی

            بقول علامہ مرحوم، مولانا حالی کے بعد کسی نے سننے کے لائق کچھ کہا ہے، تو وہ مولوی محمد اسمٰعیل صاحب میرٹھی ہیں، افسوس کہ دوسرا حالی بھی اس مہینہ ہماری دنیا سے رخصت ہوگیا، مرحوم کا سہل و رواں کلام ہمارے بچوں کا ابتدائی سبق تھا، وہ اپنی پیرانہ سالی کی مرتعش زبان سے چھوٹے چھوٹے بچوں کو اس پیار سے سمجھاتے تھے کہ وہ نصیحت کی گرانباری کو کھلونا سمجھ کر اٹھا لیتے تھے، افسوس کہ یہ کھلونے بنانے والا بھی اب نہ رہا، سرکاری خدمت سے گوشہ نشین ہوکر وہ ہمہ تن علمی خدمات میں مصروف ہوگئے تھے، تدوین کلام خسرو کے سلسلہ میں قران السعدین کی تقریظ و تحشیہ سے فارغ ہوکر حیات خسرو کی ترتیب میں مصروف تھے، اس کے علاوہ قواعد اردو اور لغات اردو کی تکمیل کا کام شروع ہورہا تھا، جو افسوس کہ ناتمام رہا، میرٹھ میں ایک مدرسہ بنات المسلمین بھی آپ کے اعمال حسنہ کی یادگار ہے۔ (سید سليمان ندوی، نومبر ۱۹۱۷ء)

فلسفۂ اخلاق کی تشکیل نو اور سیرت طیبہ میں اس کی نظریاتی بنیادیں

Reformation of Moral Philosophy and its Foundation in Seerah of the Prophet Muhammad (ﷺ) Though, the twenty first century is passing through a great development in the field of science, intellect, education and technology, human beings seem spiritually and ethically in a more miserable condition day by day. We observe inflation in the problems and complications regarding their solutions in human societies with every passing day. Today’s man is highly engaged in universe and its enquiry, we are developing knowledge and physical efforts for taking control over all phenomena of universe, but in this effort, we lost our capability of good values and ethics mostly. In such conditions, the one and only personality, the Ambassador of peace, beloved Muhammad ﷺ is the source of guidance, by whom the spirit of a man could meet with peace and stability. But the solution of this major problem never can be just adopting his ethical teachings and the rejection of bad actions. If so, then the thousands of past writings about the issue have brought the revolution already on the face of the earth. Modern philosophy of ethics and Morality is based upon the concept of relativity as “Good” or “bad” is not universal truth at all. For this reason, it is less effective in terms of practicality. The roots of philosophical concepts we find in the teachings of Prophet’s Muhammad (ﷺ). Have no enigmas and ambiguity Morality. Promoting the prophetic philosophy of Ethics and Morality can change the behavior of man automatically rather than forcefully. In this article, effort has been made to critically analyze the modern Moral philosophy in the light of Sῑrah of the Holy Prophetﷺ. Analytical and critical research methodology is adopted in this study.

Combinatorial Design, Synthesis, Bioevaluation and Sar Studies on Some Small Drug‐Like Molecular Libraries

A combinatorial synthesis of small libraries of a variety of amino chalcones has been carried out in solution phase under standard Claisen Schmidt conditions. The compounds were tested for their potential as antibacterial and cytotoxic agents as well as phosphatase inhibitors and the leads were identified in each bioassay. Chalcone 7 was found to have strongest potential as cytotoxic agent, while chalcone 11 be the most potent PGM inhibitory agent. Parallel synthesis of a 120 member chalcone library was carried out as mixture synthesis following the positional scanning protocol. The identification of lead in this library was carried out by deconvulution and chalcones 22 and 41 were found to be the most potential candidates to be developed as antibacterial agents. Following the same strategy of mixture synthesis, another 175 member chalcones library was synthesized and most potent anticancer chalcones 31, 61 and 78 were identified by deconvolution through position scanning protocol. Peptidyl α,β- unsaturated ketones were synthesized as novel bis- electrophiles susceptible for 3+2 and 3+4 annulations. As a result, peptidyl oxazoles, pyrazolines, pyrazoles, benzothiazepines and benzodiazepines were synthesized. Potent antidiabetic chalcones were docked into the PGM active site and a rationale was found for greater antidiabetic activity of chalcones over the other. Rational design and synthesis of some cytotoxic chalcones was based on 3DQSAR studies using CoMFA as a tool. 3DQSAR studies were also carried out on a library of 30 chalcones as potential antitumor agents.
Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.