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پارک دی سیر

پارک دی سیر
پارک دے وچ گھمن والے آندے دل پرچاون لئی
عورت مرد تے بہتے وڈے آندے دکھ گھٹاون لئی

صبح سویرے منہ ہنیرے سیر کرن نوں آندے نیں
بہتی عمراں والے بھائی چھیتی ہی تھک جاندے نیں
تھوڑی عمر دے گھبرو اوتھے آکے خوشیاں پاندے نیں
بہتے آندے اوتھے اپنا اپنا دکھ ونڈاون لئی

فجری اٹھ خدا دے بندے سر سجدے وچ دھردے نیں
شرع شریف دے تابع رہ کے ذکر خدا دا کردے نیں
صبر شکر دا پہن لبادہ ہر دم دکھڑے جردے نیں
دکھاں وچ وی نہ گھبراون رب سوہنے نوں پاون لئی

شوگر والے بھائی میرے! ایہہ تیری مجبوری اے
تڑکے اٹھ کے سیر نوں جانا تیرے لئی ضروری اے
پڑھ الحمد اکتالی واری ایہہ فرمان حضوریؐ اے
ایہدے نال درود رلا ، ایہہ ورد ہے دکھ ہٹاون لئی

بچے کرن تیاری ایتھے جد پرچے ہون سالانہ
کئی وچارے غربت مارے، کئی پئے دین ماہانہ
محنت دے ہن نمبر ملدے بھاویں شکل شاہانہ
محنت تے رب رکھدا ناہیں، دسی اے گل سمجھاون لئی

بہتے موٹے بھاری بندے سو سو نفل گزارن!
غم اندوہ سب دور ہو جاون کدی ناں ہمت ہارن!
قبر حشر نوں سامنے رکھ کے نفس اپنے نوں مارن
بڑا ای چنگا نسخہ ہے اے رب دے نیڑے آون لئی

سجری خوشبو پھلاں والی ہر پاسوں پئی آوے
پھل کلیاں دی مہک پیاری ہر اک نوں پئی بھاوے
جوں جوں خوشبو ودھدی جاوے دل سکون وی پاوے
باغ باغیچے لائے سارے تیرا جی بہلاون لئی

کڑیاں وی کدی سیر بہانے پارک دے وچ آندیاں نیں
پکڑ موبائل گھمدیاں پھردیاں اپنا دل بہلاندیاں نیں
نکھرا مکھ...

Disease Spectrum in COVID-19 Cohort with Travel History from Iran

Background: Coronavirus disease 2019 (Covid-19), declared as a pandemic in March 2020, is an acute respiratory tract illness caused by coronavirus 2 (SARS-CoV2) with clinical manifestations ranging from mild upper respiratory tract symptoms to severe pneumonia. Objectives: To determine the disease spectrum of Covid-19 in a cohort with a travel history from Iran. Materials & Methods: This cross-sectional study with a retrospective collection of data was conducted at Agha Khan University, Karachi from 15th March to 19th April 2020. One hundred and fifty-five laboratory-confirmed cases of Covid-19 were recruited from a government quarantine facility. Data were obtained from the Punjab Emergency Services (Rescue 1122) database where a record of SARS-CoV-2 positive cases and quarantined persons is maintained. Study subjects with a travel history to Iran were contacted by telephone to obtain information about demographics, symptoms, and co-morbid conditions.  SPSS version 24 was used to analyze the data. Frequencies and percentages were calculated. Results: Among the returning travelers, 213 had laboratory-confirmed Covid-19, out of which 155 were included in this study. 56.1% were males with a mean age of 40 years. Among the study participants, 91.6% remained asymptomatic throughout the stay, while 8.4 % became symptomatic. 77.5% of the participants had received BCG vaccination in childhood. Among symptomatic cases 15.4% had asthma and 7.7% had hypertension. The most common clinical manifestation was cough which was present in 38.5% of the study participants. None died among the study participants. Conclusion: A mild presentation of COVID-19 was seen in our study participants with 91.6% among them being asymptomatic, while 8.4% were symptomatic. There was a high positivity rate in males as compared to females.  

Synthesis, Characterization and Biological Activities of Drugs-Metal Complexes

Accelerated research in the field of Co-ordination chemistry has vitalize the scientists world over to consider transition metals as possible powerful agents to enhance the pharmacological activities of different drugs. Additionally, it has been explored that accompaniment of transition metal ions to a drug not only potentiates the already known pharmacological action of the drug but may also be responsible for exhibition of newer activities of the compound unnoticed hitherto. Medicinal inorganic chemistry is flourishing with successful clinical application of many metal complexes. Based on these findings the present work aims at synthesizing various transition metal complexes of some reputable and well practiced pharmacological agents. The drugs included antimicrobial agents, Isoniazid and Pyraziamide, antihypertensive agent, Losartan, antimycotic Fluconazole and oral hypoglycemic agent, Biguanide Metformin. Copper, Nickle, Cobalt, Mangnese, Iron and Cadmium ions were used for complex formation. The structures and characterization of all synthesized complexes were established and characterized by using FTIR, UV-visble, NMR, elemental analysis, AA, SEM and XRD data and their physicochemical properties was done by melting point, color, solubility, conductance and magnetic susceptibility values. The metal complexes of Isoniazid and Pyrazinamide were evaluated for their antimycobacterial activity against Mycobacterium strains resistant to commonly used anti tuberculous agents. Furthermore, all complexes were evaluated for their cytotoxic, antiplatelet and antibacterial activities. Cobalt complex of Pyrazinamide were found active against all resistant tuberculous mycobacterium strains while the Mangnese complex of this drug showed anti mycobacterial activity against two of the strains. All complexes of Isoniazid demonstrated activity against resistant strains of Mycobacterium Tuberculosis, Copper complex of Fluconazole exhibited cytotoxic activity against all four cancer cell lines whereas Cobalt and Iron complexes were cytotoxic against KB-3-1 cancer cell line. Pure Losartan was also found to be cytotoxic against cervical carcinoma cell lines. Contrary to these findings, Biguanide metformin metal complexes were inactive in terms of cytotoxic, antibacterial and antipletelet activities depicting no encouraging results.
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