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سیر گیری اور ترمینل نمبر۱

سیر گری اور ترمینل نمبر1

قاہرہ سے شرم الشیخ جانے کے لیے نیل نامی ہوائی کمپنی کے جہاز میں محمد علی نے میرے ساتھ سفر کرنا تھا جلد ہی ہم دونوں میں ذہنی ہم آہنگی پیدا ہوئی اور مصریوں کے بارے میں میری رائے اچھی بننے لگی ۔قاہرہ کے ائیر پورٹ کے ترمینل نمبر 1پر عجیب چہل پہل تھی ، بھانت بھانت کے لوگ ،بھانت بھانت کی بولیاں بولتے عجیب و غریب لباس زیب تن کیے جوق در جوق اس ترمینل کی انتظار میں ٹولیوں کی شکل میں بیٹھے تھے۔سرخ،کالے ،بھورے ،زرد جتنے انسانوں کے رنگ اس سے زیادہ بولیاں ۔مسافر نے کرنسی تبادلے کی دکان پر موجود ایک خوش گفتار مصری سے پوچھا کہ یہ لوگ کن کن علاقوں سے یہاں آتے ہیں اور اس ترمینل سے کس منزل کی طرف جا رہے ہیں؟۔جواب ملا کہ دنیا بھر سے آتے ہیں؟مگر زیادہ تر لوگ روس سے آتے ہیں ۔میرے استفسار پر کہ اس ترمینل میں رقوم کے تبادلے کی کتنی دکانیں ہیں،اس نے کہا چار ۔پوچھنے پر پتہ چلا کہ صرف ایک دکان پر روزانہ تقریباََایک لاکھ امریکی ڈالر مصری پائونڈ میں تبدیل ہوتے ہیں چار دکانوں پر یہ تبادلہ ماہانہ ایک کڑو ر بیس لاکھ تک ہوتا ہو گا یہ آمدنی صرف سیر گری سے حاصل ہو رہی ہے ۔اس ترمینل سے اسکندریہ اور شرم الشیخ کی طرف صرف ان جہازوں کو اڑان بھرنے کی اجازت تھی جو مصری عوام و حکومت کی ملکیت میں تھے اور جہازوں کے کرائے بھی ان سیاحوں نے ڈالر وں میں بھرنے ہوتے ہیں ۔

مسافر نے سال پہلے عصرِ حاضر کے ’’مہا گرو‘‘اور ’’استاذالاساتذہ ‘‘ Googleجس کے شاگرد قریہ قریہ ،کوچہ کوچہ ا ور یم بہ یم پائے جاتے ہیں ،سے پوچھا کہ انسان سیر گری پر سالانہ کتنا خرچ کرتا...

HOMESCHOOLING: A FORMULA FOR ESTABLISHING ISLAMIC EDUCATION IN REMOTE COMMUNITIES IN INDONESIA

The disparity in the equality of education in Indonesia, especially in backwoods areas, is one of the problems of education in Indonesia. One of the Government's action in overcoming this gap is by distributing teachers to remote areas of the country. In addition, the government also stipulates several laws and regulations as the formal legality of education in backwoods communities. This study aims to explore the possibility of implementing the homeschool education model (homeschooling) for backwoods communities, as an effort to applied Islamic subject matter and prevail education in Indonesia. This study uses a naturalistic phenomenological approach, using triangulation as one of the data analyzes. The research location is in Hansibong, a backwoods hamlet in the Sojol mountains of ParigiMoutong district, Central Sulawesi. The results of this study found that education in Hansibong is carried out informally within the family. Learning process is held in a traditional way, using very minimal of media, methods and subject matter. The material taught is limited to morality values, reading and writing, arithmetic and the ability to survive in nature. Islamic education in its function as a strengthening of cognitive intelegence, morals, spirituality and nationality has not been provided in learning at home. As a research implication, a homeschooling socialization effort is needed so that the student community can continue to a higher level. The implementation of homeschooling that is not in accordance with the technical guidelines issued by the government will only disserve students because learning outcomes cannot be equalized with existing education levels.

Association of Genetic Variants and Environment With the Risk of Asthma

Asthma and allergy are common and complex diseases often co-occurring within the same individual. Genetic as well as environmental factors such as consanguinity and early sensitization to allergens significantly influence the onset and progress of the disease. Aim of the following study was to investigate the association of environmental factors and selected single nucleotide polymorphisms (SNPs) from candidate genes with asthma in Pakistani population. The studied population consisted of 368 genetically unrelated volunteers. Three SNPs from 2 genes Group Specific Component gene GC (rs4588 and rs7041) and Glutathione S-Transferase P1 gene GSTP1 (rs1695) were selected for genotype analysis by Restriction fragment length polymorphism (RFLP), whereas 15 SNPs form Interleukin 33 gene IL33 (rs1412426, rs1342326, rs992969, rs928413, rs2066362, rs996029, rs10815388, rs10975501, rs17498196, rs10975516, rs10975519, rs7047921, rs1332290, rs16924241 and rs8172) were selected for ABI’s Taqman 7900 genotyping. Mean age was 34.04± 16.30 for males and 33.89±13.15 for females whereas the mean BMI was 22.01±4.04 for males and 23.23±5.21 for females. About 68.20% subjects lived in urban areas and 31.79% lived in rural areas. Parents of 87.5% of the studied population had married within their own caste system, 60.05% of which were first cousins. Family history of Asthma was prevalent in 48.91% of the Asthmatic population. Total 60.86% asthma cases were classified as adult and 39.13% cases were classified as pediatric onset asthma, based on the age at which the diagnosis of asthma was concluded. Asthma severity was based on the percent predicted FEV1 and categorized as intermittent (2.71%), mild persistent (0.54%), moderate persistent (40.21%) and severe persistent (56.52%). Total serum IgE levels were 121±2.91 lU/mI for the control population and 584.2±4.61 lU/mI in asthmatics. Males had higher IgE levels (181IU/ml) than the females (99lU/ml). Amongst the atopic manifestations cough was the most prevalent symptom (82.06%) closely followed by wheeze (80.97%) whereas skin allergies were the least prevalent (22.82%). Seasonal variations were reported to be the most significant asthma trigger (95.65%) followed by dust (72.82%) and food allergies (60.32%). Asthma attacks were more frequent in winter season (57.06%) and in transitional period between changing seasons (48.36%). Only 3.80% reported no seasonal correlations with asthma. Smoking asthmatics constituted 11.41% of the studied asthmatic population whereas 62.5% were exposed to tobacco smoke for long periods of time, 51.08% asthmatics were exposed to tobacco smoke but never smoked themselves. Homeopathic medicine was used by 14.67% and 33.69% turned to Hakeems however; the use of complimentary alternate medication remained the most popular (39.13%) mostly due to the lack of side effects associated with such treatments. Total 18 SNPs from 3 candidate genes were genotyped using RFLP and ABI’s Taqman. RFLP was carried out in 2 genes (GC/VDBP, GSTP1). Significant association of GC/VBDP GC2 homozygote asthma was established (OR = 3.14, 95% CI = 1.786 - 5.535, p = <0.001) through 90% reproducibility. GSTP1 Ile/Ile homozygote showed significant association with asthma (OR = 2.33, 95% CI = 1.347 - 4.043, p = 0.003) in Pakistani population. 15 SNPs from Interleukin-33 were genotyped on the ABI platform. rs17498196 (OR = 1.78, 95% CI = 1.18- 2.68 p = 0.005) and rs992969 (OR = 1.42, 95% CI = 0.99- 2.04 p = 0.05) were significantly associated with the risk of asthma, however the risk becomes non-significant with cousin parents removed rs17498196 (OR = 2.42, 95% CI = 1.23- 4.74 p = 0.01) and rs992969 (OR = 1.41, 95% CI = 0.80- 2.48 p = 0.23) respectively. These results highlight the importance of consanguineous unions in inheritance of asthma as a genetic disorder. LD analysis between the SNPs revealed strong linkage disequilibrium between rs10975516, rs10975519, rs7047921 and rs1332290 even with cousin parents removed remaining good predictors of each other. rs1412426, rs1342326, rs992969 and rs928413 showed moderate LD which further decreased with cousin parents removed, implicating consanguinity in the inheritance of asthma risk allele.
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