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مولوی عبدالغنی انصاری

عبدالغنی صاحب انصاری
دارالمصنفین کے لیے دوسرا حادثہ مولوی عبدالغنی صاحب انصاری ریٹائرڈ کمشنر انکم ٹیکس کی وفات کا ہے، مرحوم علامہ شبلی کے عزیز دارالمصنفین کے پرانے ہمدرد ہواخواہ اور اس کی مجلس انتظامیہ کے رکن تھے، ان کی ذات میں جدید و قدیم دونوں کی خوبیاں جمع تھیں، جدید تعلیم کے ساتھ پرانی وضعداری اور تہذیب و شرافت کا نمونہ تھے۔ اپنے دور کے قابل ترین افسروں میں ان کا شمار تھا، اپنی قابلیت حسن اخلاق اور سیرت و کردار کی پختگی کی وجہ سے حکومت اور پبلک دونوں میں مقبول و ممدوح تھے، ریٹائر ہونے کے بعد قومی کاموں میں بھی دلچسپی لیتے تھے، ادھر عرصہ سے ان کی صحت خراب تھی، گذشتہ مہینہ کراچی میں انتقال کیا۔ اﷲ تعالیٰ ان کی مغفرت فرمائے۔ (’’م‘‘، ستمبر ۱۹۶۲ء)

 

Islam and Forced Conversion: A Misunderstood Concept

Religion and marriage are two vital components of an individual’s life. Major world religions have guided human beings not only in theology but also in the matter related to marriage. Islam recognizes the need of its adherents for having matrimonial relationship with the women of the people of scripture in a pluralistic society. It has permitted its males followers for getting married with Christian females and vice versa is not permitted. In history, Muslims have been practicing such interfaith marriages and some of Muslim rulers also availed this relaxation. This paper discusses the marriages of Muslim rulers with Christian ladies enumerating various married couples. Among such rulers are included Umayyads caliphs, Spainish amirs, Ottoman sultans, Mughal emperor and some contemporary rulers. The effects of these interfaith marriages have also been analyzed.

Synthesis and Characterization of Potentially Biologically Active Derivatives of Polyhydroquinoline and Quinoline Ring Systems

Multi-component reactions (MCRs) have emerged as an efficient and powerful tool in modern synthetic organic chemistry allowing the facile creation of several new bonds in a one-pot reaction. Clearly, for multi-step synthetic procedures, the number of reactions and purification steps is among the most important criteria for the efficiency and practicability of a process The classical four-component Hantzsch condensation provides access to pharmaceutically active polyhydroquinolines. We had carried out the reactions of cyclohexanone or cyclohexane dione or dimedone with malononitrile or ethylacetoacetate and different aliphatic and substituted aromatic aldehydes in the presence of ammonium acetate in ethanol. These multicomponent reactions were carried out both by solvent free grinding and by classical heating for comparison purposes. The catalytic activity of p-TSA (10 mol %) and guainidine HCl (5 mol%) in these reactions was tested over a set of aldehydes. Through catalytic screening, guainidine HCl (5mol%) at ambient temperature is proven to act as a very active catalyst for multicomponent reactions (MCRs) of 2-amino-4-phenyl-3-cyano-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives and 2-methyl-4-phenyl-5-oxo-1,4,5,6, 7, 8- hexahydroquinoline-3-carboxylate in excellent yield up to 96% from aldehydes, 1,3-cyclohexadione, malanonitrile/ ethylacetoacetate and ammonium acetate. we develop an expedient multi-component synthesis of 2-amino-5-oxo-4-substituted phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 4-4f and 2-amino-5-oxo-4-substituted phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate 5-5l by using P-TSA under ultraviolet irradiation. Chemical reactions were carried out by the absorption of long-wavelength ultraviolet light by reactants to form product in a short period of time. We carried out the synthesis of polyhydroquinoline via irradiating the cyclohexanone/ cyclohexane dione/ dimedone with malononitrile/ethylacetoacetate and different aliphatic and substituted aromatic aldehydes in the prescence of ammonium acetate and P-TSA catalyst in ethanol assisted with ultraviolet light. The absorption of ultraviolet radiation by substrate allows a reaction to proceed by bringing the molecule to the activation energy, by changing the symmetry of the molecule and by changing the configuration of molecules. The reaction time is reduced from 1.5h to 4-5 min whereas % yield increased significantly by the ultraviolet assisted reactions. Thus, the superiority of the ultraviolet assisted protocol for the synthesis of polyhydroquinoline over thermal method had proved. Extensive biological studies on these v polyhydroquinolines with a variety of substitution patterns exhibit that these compounds have a mild potential of antimicrobial and antioxidant activities. Chalcones are secondary metabolites of terrestrial plants, precursors for the biosynthesis of flavonoids and exhibit various biological activities. A simple and regioselective synthesis of substituted 2-chloro-3-formyl quinolines through Vilsmeier-Haack cyclization of N-arylacetamide bearing an electron donating group at the meta position was carried out. Yields with electron donating groups were good in all cases. First, the chalcones were synthesized by direct Claisen-Schmidt condensation reactions between an equimolar quantity of quinoline-3-formaldehyde and different heterocyclic/aromatic ketones (a-i) by a base catalysed (40% NaOH solution) condensation. The 1H-NMR spectra of the synthesized compounds were in good agreement with the structures of the synthesized compounds. Extensive pharmaceutical studies in literature on various other quinolinyl chalcones indicate that these compounds have a significant potential of biological activity.
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