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ایرج افشار

جناب ایرج افشار کی رحلت
(رئیس احمد نعمانی)
پوسٹ بکس نمبر ۱۱۴،
علی گڑھ (ہند) ۲۰۲۰۰۱۔
برادر گرامی مراتب زید مناصبکم، السلام علیکم و رحمۃ اﷲ و برکاتہ!
۳؍ مارچ ۲۰۱۱؁ء کو ایران کے معروف اسکالر اور پبلشر جناب ایرج افشار دنیا سے رخصت ہوگئے، ایک مخلص کی اطلاع اور فرمائش پر یہ قطعۂ تاریخ لکھا ہے، امید ہے اس کو ’’معارف‘‘ میں جگہ دینے کی زحمت فرمائیں گے۔
جویائے خیر
رئیس احمد نعمانی
تاریخ در گذشت دکتر ایرج افشار
;دانشمند و پڑھشگر معروف ایران
یگانا مردِ دانا ایرج افشار
سخن گوی و سخن سنج و سخن یار
ادیبِ نامور، استادِ انشاء
چراغ بزمِ تحقیقات و جستار
رفیق رہروانِ راہ پارین
انیس ہمریانِ تازہ رفتار
کتاب و نامۂ اہلِ ادب را
ہمی بودہ امین و ہم نگہدار
مہارت داشت در تالیف و تدوین
علَم گردیدہ ہم در چاپ آثار
عزیز خاطر دانا و نادان
ستودہ از زبانِ خویش و اغیار
چو دل برداشتہ از کارِ دنیا
رمیدہ از ہجوم شہرو بازار
ہستہ رختِ جان و تن ز منزل
جہانیدہ بہ سوی گور رہوار
بجستم سالِ فوتش و ز دلِ من
صدا آمد: ’’دریغا ایرج افشار‘‘
۲۰۱۱ء
(۳ مارچ/۲۰۱۱ء)
( مئی ۲۰۱۱ء)

A Critical Analysis of Marxist Feminist Multi-Voiced Expressions in Pakistani Writings

Pakistani English literature is internationally recognized. It elaborates on Pakistani culture, societies, and individual and collective thought represented in its writings. Different writers have different perspectives to discuss, but Marxist Feminism is an important aspect about which very few writers focused, on the point of view of the property, dominance, wages, and shares in the economy. Men are not only denominated on women’s bodies but also their economy, which females deserve in the form of inheritance or wages. Karl Marx and Frederic Engels wrote a book: The Origin of Family, Private property, and the State (1884), and presented a theory on Marxist-feminist phenomena that men and women do the same job, but women receive the reward not equally men. This can be because of males’ dominant society or, in other words, females are not aware of their basic rights. This study is the subjective analysis of reading the two novels of the pre-modern time: Umrao Jaan Ada by Hadi Ruswa and the post-modern era fiction: The Holy Woman by Qaisra Shahraz to analyze the custom prevalent in the society of Pakistan regarding the Marxist-feminist approach. The hypothesis is also, whether the situation varies after a hundred years of awareness. However, the study has the conclusion of the same state.

Appraisal of Ajuga Bracteosa Wall. Ex Benth. As a Promising Natural Source of Bioactive Leads

The traditional plants occupy fundamental place for the fulfillment of healthcare needs in developing countries. The current study was aimed to purify and characterize bioactive leads from a medicinal folklore, Ajuga bracteosa Wall. ex Benth. Initially, total fifteen extracts were prepared from dried powdered plant material in different solvent systems using ultra sonication aided maceration. These extracts were evaluated to reconnoiter phytochemical and biological (i.e., antioxidant, antimicrobial, cytotoxic and enzyme inhibitory) attributes. Existence of huge amounts of polyphenols was confirmed in methanol extract (via RP-HPLC analysis) along with highly promising antioxidant and protein kinase inhibitory activities and moderate α-amylase inhibitory, antileishmanial and cytotoxic potential. Therefore, methanol was selected as the most suitable solvent for bulk extraction. Afterwards, the preparative extract (ABCM) was partitioned through solvent-solvent extraction and the resultant main fractions (i.e., ABH, ABE and ABW) were processed through various chromatographic procedures by simultaneously gauging their activities against antioxidant, enzyme inhibitory and cytotoxic assays. AB1 was isolated from its ABH fraction with prominent α-amylase inhibitory activity (IC50 119.4±0.22 µg/ml). AB2, AB3, AB4 and AB5 were isolated from ABE fraction. AB2 gave moderate protein kinase inhibitory potential (i.e., 7.67±0.58 mm bald zone of inhibition). AB3 and AB4 manifested good cytotoxic potential (with LC50 111.52±0.24 and 78.56±0.53 µg/ml respectively) while AB4 also showed good free radical scavenging (with IC50 10.4±0.32 µg/ml) and α-amylase inhibitory potential (with IC50 134±0.56 µg/ml). Magnificent total antioxidant and reducing activities (i.e., 182.8±0.72 and 760.12±0.64 µg AAE/mg compound respectively) were shown by AB5. The ABW fraction resulted in AB6 with moderate cytotoxic potential (with LC50 183.42±0.57 µg/ml). X-ray crystallographic and spectroscopic studies characterized AB1, AB2, AB3, AB4, AB5 and AB6 as 2, 3dihydroxy propyl palmitate, ajugarin I, apigenin, luteolin, ajugarin VI and 8-Oacetylharpagide respectively. In vivo activities including antiinflammatory, analgesic, antidepressant and anticoagulant were designed for further confirmation of the above said activities at compound level. The results revealed high dose (HD, 20 mg/kg) of AB2, AB3 and AB6 to be potent antiinflammatory agents with values ranging between 70-90% edema inhibitions. AB1, AB2 and AB6 showed excellent analgesic behavior with > 90% increment in pain threshold whereas HD and LD (low dose, 10 mg/kg) of AB2 showed maximum antidepressant activity in the range of 90-100 seconds. The remarkable anticoagulant profile (with 143±4.77 seconds for blood coagulation) was shown by HD of AB6. On the basis of previous hepatoprotective reports from the subject plant, the most abundant compound, AB2 was selected for confirmation of hepatoprotective and renoprotective aspects using in vivo CCl4 toxicity model. Endogenous antioxidants i.e. superoxide dismutase, catalase, peroxidase, glutathioneS-transferase and reduced glutathione were revitalized with HD (4 mg/kg) of AB2 exhibiting the activity levels of 4.54±0.39, 4.22±0.41 and 9.02±0.79 U/min, 18.97±1.79 nM/min/mg protein and 20.3±1.7 nM/mg protein respectively. Reduced serum levels of hepatic as well as renal markers i.e. alanine transaminase, aspartate transaminase, alkaline phosphatase (with 43.7±0.21, 37.2±0.13 and 201.3±0.029 U/l respectively), urea and creatinine (with 24.07±0.19 and 0.98±0.11 mg/dl respectively) were observed with HD of AB2. The lipid profile also showed ameliorative effects for serum triglycerides and cholesterol (i.e., 104±0.34 and 147.2±0.03 mg/dl respectively) at HD. Abnormalities in histoarchitecture of both the organs were curbed by HD of the compound indicating its regenerative properties. In principle, the aforementioned findings endorses A. bracteosa as a substantial source of bioactive leads with marvelous pharmacological spectrum.
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