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پروفیسر شہریار

مظہر امام /پروفیسر شہریار/پروفیسر مغنی تبسم
افسوس اس ماہ فروری میں اردو کے آسماں پر درخشاں، چند ستاروں کے چھپ جانے سے اردو دنیا کی رونق میں کمی آگئی، جناب مظہر امام ، پروفیسر شہریار ، پروفیسر مغنی تبسم یکے بعد دیگرے رخصت ہوئے، مظہر امام کی شناخت آزاد غزل کے حوالے سے ہے، کئی شعری اور تنقیدی کتابوں کے مصنف تھے، پروفیسر شہریار اور پروفیسر مغنی تبسم، ہندوستان کی دو ممتاز جامعات یعنی مسلم یونیورسٹی اور جامعہ عثمانیہ میں اردو کے کامیاب اور نامور استاد ہی نہیں، شعرو ادب کی دنیا میں صاحب مرتبہ و مقام بھی تھے، شہریار کی شہرت گو ان کی زندگی کے دور آخر میں خوشبو کی طرح عام ہوئی لیکن نشاط غم اور رنج شادمانی کے مختصر اور فانی لمحات کا ساتھ عمر بھر رہا، ان کی شہرت کے شہپر جب سمٹے ہوئے تھے اس وقت بھی انہوں نے اس خاموشی کو بلیغ معانی دیے تھے، خواب، رات، دیار، پرچھائیں، سفر، تشنہ لبی کے پردے میں وہ دیار دل اور بزم دوستاں تلاش کرتے رہے، مغنی تبسم شہریار کے پیشہ تدریس میں ہی شریک نہیں رسالہ شعرو حکمت میں بھی برابر کے سہیم تھے، وہ حیدرآباد کے دائرہ ادبیات اردو اور رسالہ سب رس سے مدتوں وابستہ رہے، فانی بدایونی پر تحقیق کی تھی، درجنوں کتابیں لکھیں، عجیب بات ہے کہ ادبی سفر میں مغنی تبسم اور شہریار ساتھ ساتھ رہے، ابدی سفر میں بھی یہ رفاقت قائم رہی، شہریار کے نام ایک خط میں مغنی تبسم نے لکھا تھا کہ ’’شاعری تو ایسی چیز ہے جو خدا، انسان اور کائنات کے درمیان پچھلی راتوں کا دعائیہ بن جاتی ہے، کتنے لوگ ہیں جوان ساعتوں میں دست دعا دراز کرتے ہیں‘‘، مغفرت کے لیے کوئی عمل یا کوئی قول کام آسکتا ہے، ہمارا دست دعا بھی اسی لیے دراز ہے۔...

سورۃ نور کے تناظر میں مفتی محمد شفیع ؒ کےفقہی طرزاستدلال

Mufti Muhammad Shafi's tafseer is an important and educational extract in the Quranic field. Tafseer Muarif ul Quran has its own relevance and rank amongst others. This tafseer concentrates on current fiqhi issues and gives their solutions with strong signs It is also discussed social issues of the society. This article examines the fiqhi style and qualities of Mufti shafi "especially the study of Surah Noor" which are prominent factors of the Tafseer. This Tafseer has converted difficult terms and words into easy ways and elaborated Quranic verses with Hadith and old translations.

Synthesis and Characterization of Potentially Biologically Active Compunds Derived from Fibric Acids.

The present study deals with the synthesis of fibric acids derivatives. The thesis has been divided into three parts (1) Synthesis of fibric acids derivatives (2) Biological screening (3) In silicio studies. In the first part of thesis two fibric acids (2a & 2b) were synthesized from two phenols (1a & 1b) followed by their conversion into corresponding esters (3a & 3b) and carbohydrazides (4a & 4b). Cyclization of these carbohydrazides was carried out to synthesize 1,3,4-oxadiazoles (5a & 5b). In next step N-substituted-2-bromoacetamides (7a- 7y) were prepared by using various anilines (6a-6y). Two main series of compounds 8-30 and 31-50 were synthesized successfully by reacting 5-(2-aryloxypropan-2-yl)-1.3.4- oxadiazol-2-thiols (5a & 5b) with N-substituted-2-bromoacetamides (7a-7y). Characterization of the compounds was carried out through spectroscopic analysis. N N O CH3 CH3 O X SH (5a-5b) 5a X=Cl 5b X=Br (Scheme 1) xiv Br N H O R1 R2 (7a-7y) 7a Cyclohexylamine 7j R1 = 3CH3 R2=5CH3 7s R1 = H R2=2Br 7b R1 = H R2=H 7k R1 = H R2=4C2H5 7t R1 = H R2=3Br 7c R1 = H R2=2CH3 7l R1 =2C2H5 R2=6CH3 7u R1 = H R2=4Br 7d R1 = H R2=3CH3 7m R1 = H R2=2OCH3 7v R1 = H R2=2Cl 7e R1 = H R2=4CH3 7n R1 = H R2=3OCH3 7w R1 = H R2=4F 7f R1 = 2CH3 R2=3CH3 70 R1 = H R2=4OCH3 7x R1 = H R2=4NO2 7g R1 = 2CH3 R2=4CH3 7p R1 = H R2=2OC2H5 7y R1 = H R2=2NH2 7h R1 = 2CH3 R2=6CH3 7q R1 = H R2=4OC2H5 7i R1 = 3CH3 R2=4CH3 7r R1 = 2OCH3 R2=5Cl (Scheme 2) N N O CH3 CH3 O Cl S N O H R1 R2 (8-30) 8 Cyclohexylamine 16 R1 = 3CH3 R2=4CH3 24 R1 = 2OCH3 R2=5Cl 9 R1 = H R2=H 17 R1 = 3CH3 R2=5CH3 25 R1 = H R2=2Br 10 R1 = H R2=2CH3 18 R1 = H R2=4C2H5 26 R1 = H R2=4Br 11 R1 = H R2=3CH3 19 R1 =2C2H5 R2=6CH3 27 R1 = H R2=2Cl 12 R1 = H R2=4CH3 20 R1 = H R2=2OCH3 28 R1 = H R2=4F xv 13 R1 = 2CH3 R2=3CH3 21 R1 = H R2=4OCH3 29 R1 = H R2=4NO2 14 R1 = 2CH3 R2=4CH3 22 R1 = H R2=2OC2H5 30 R1 = H R2=2NH2 15 R1 = 2CH3 R2=6CH3 23 R1 = H R2=4OC2H5 (Scheme 3) N N O CH3 CH3 O Br S N O H R1 R2 (31-50) 31 Cyclohexylamine 38 R1 = 2CH3 R2=6CH3 45 R1 = H R2=2OC2H5 32 R1 = H R2=H 39 R1 = 3CH3 R2=4CH3 46 R1 = H R2=4OC2H5 33 R1 = H R2=2CH3 40 R1 = 3CH3 R2=5CH3 47 R1 = 2OCH3 R2=5Cl 34 R1 = H R2=3CH3 41 R1 = H R2=4C2H5 48 R1 = H R2=2Br 35 R1 = H R2=4CH3 42 R1 =2C2H5 R2=6CH3 49 R1 = H R2=3Br 36 R1 = 2CH3 R2=3CH3 43 R1 = H R2=3OCH3 50 R1 = H R2=4Br 37 R1 = 2CH3 R2=4CH3 44 R1 = H R2=4OCH3 (Scheme 4) After the successful completion of synthetic portion and their characterization fibric acids derivatives were evaluated for their biological activities. For this purpose, protocols of anti-thrombotic (in vitro and in vivo) and anti-inflammatory activity (in vitro and in vivo) were followed. The anti-thrombotic activity (in vitro and in vivo) was performed to evaluate the FXa inhibition potential of newly synthesized compounds. In vitro, compounds 17, 27 and 36 showed higher % age of clot lysis than standard drug streptokinase; however the xvi remaining compounds showed moderate to good activities. In vivo, for compounds 9, 12, 13, 16, 17, 24, 27, 32, 36, 39, 41, and 48 enhanced clotting times (even better than standard drug heparin) were observed. Anti-inflammatory activity was performed to evaluate the COX-2 enzyme inhibition potential of fibric acids derivatives. In vitro, these compounds showed moderate to good activity while in vivo compounds 8, 9, 11, 12, 16, 17, 24, 34 and 48 showed results even better than standard drug diclofenic sodium. Compounds 14, 15, 19, 21, 31, 38 and 42 results were comparable to that of standard drug while remaining compounds exhibited moderate activity. In the last part of research work in silico studies were performed for selected compounds. For anti-thrombotic activity compounds 9-17 were docked against FXa protein. Except the compound 5a, all others showed higher docking score than the control ligand. In case of anti-inflammatory activity molecular docking of compounds 5a, 5b and 8-50 was carried out against COX-2 protein. All the compounds except 5a, 5b, 13 and 25 showed higher docking score than standard. Density functional theory (DFT) computed molecular properties of compounds 9-17 were also calculated by computational methodology. Results of biological activities showed good commitment with in silico study results. In future these compounds might be evaluated at molecular level.
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