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مولانا عاشق حسین سیماب اکبر آبادی

مولانا عاشق حسین سیماب اکبر آبادی
افسوس ہے پچھلے دودن کے ہی آگے پیچھے سے اردو کی بساط شعروادب کے دوپرانے اورنامور مہرے اٹھ گئے۔مولانا عاشق حسین سیماب اکبر آبادی اور مولانا احسان اﷲ خاں تاجورؔ نجیب آبادی آج کل کے عام شاعروں کی طرح شاعر یاادیب ہی نہیں تھے بلکہ صاحب فن استاذ،علم عروض ومعانی وبیان اور لغت و قواعد لسان کے بڑے مبصر اورناقد بھی تھے۔مولانا سیماب۱۸۸۰ء میں آگرہ میں پیداہوئے اورجنوری۱۹۵۱ء میں کراچی میں انتقال کرگئے شاعری اٹھارہ انیس برس کی عمر سے ہی شروع کردی تھی اس طرح گویا مرحوم نے پوری ایک نصف صدی اردو زبان وادب کی خدمت میں بسر کی۔اس مدت میں سینکڑوں چھوٹی بڑی کتابیں اوربے شمار مقالات،نظمیں وغیرہ ان کے قلم سے نکلیں۔ان کے شاگردوں کاحلقہ بھی نہایت وسیع تھا جو خط وکتابت کے ذریعہ ان کی فنی بصیرت ومہارت سے استفادہ کرتارہتاتھا۔ابتدا میں اگرچہ مرزاداغ سے مشورہ سخن کرتے تھے مگر جلد ہی ان کااپنا ایک مخصوص رنگ قائم ہوگیا۔کثرت مطالعہ وفکر عمیق نے ان میں شعروادب سے متعلق ایک مجتہدانہ شان پیداکردی تھی۔وہ کسی کے مقلد نہیں تھے بلکہ ہرچیز اورہرشعری وادبی مسئلہ کے متعلق اپنی ایک جچی تلی سنجیدہ اورمتین رائے رکھتے تھے اورعلیٰ وجہ البصیرت رکھتے تھے۔انھوں نے اپنی زندگی میں بڑے بڑے طوفانی اورانقلابی دوردیکھے جس نے ادب وشعر کی پرانی قدروں کومتزلزل کرکے رکھ دیا اورصورت ومعنی دونوں کے لحاظ سے شاعری کی دنیا میں ہنگامہ برپاکردیا، لیکن مرحوم ایک چٹان بنے اپنے مقام پرکھڑے رہے یہاں تک کہ انقلاب فکروسخن کی موجیں ان سے ٹکرائیں اوربالآخر راستہ کاٹ کر ان سے دامن بچاکر نکل گئیں۔یہ سب کچھ اس لیے ہوسکا کہ مرحوم طرزقدیم کے حامل ہونے کے ساتھ وقت کے جدید تقاضوں سے بھی بے خبر نہ تھے اورقدیم وجدید میں ہم آہنگی پیداکرلینے کاان میں بڑااچھا سلیقہ تھا۔آخر عمر...

Assessment of Blood Glucose and Calcium Concentrations Among healthy female volunteers Blood glucose & calcium in females

Abstract: Hypoglycemia and Hyperglycemia are associated with a number of complications including kidney damage, neurological damage, cardiovascular damage,  damage to the retina or damage to feet and legs,  lethargy, impaired mental functioning and irritability. The most abundant mineral in the body is calcium. Its abnormal levels also associated with multiple disorders. Objectives: The aim of this study was to assess the blood glucose and calcium levels in healthy female volunteersMethods: A cross sectional study was conducted at the Sir Ganga Ram Hospital, Lahore, over a period of 6 months, after obtaining the ethical approval from the The University of Lahore. A total number of 60 females were enrolled through consecutive sampling technique. Females of all age groups were included. All of the females had gone through routine history taking and lab investigations for the assessment of blood glucose an calcium concentrations. Results: In this study out 60 female participants, 33.3% were between ages of 15-30 years, 33.3% were between age of 31-50 years and remaining 33.3% were above 50 years old. All females of age group 15-30 years had normal glucose levels while single case of age group 15-30 years had abnormal calcium level. The results indicated that females of above age 50 years had low calcium and high glucose levels due to poor nutrition and less physical activity. Conclusions: The results of the current study showed that females with increasing age should intake food enriched in calcium and low glucose and adopt a physically active life style to manage normal blood glucose levels.

Synthesis, Structural and Biological Investigations of Vanadium V Complexes With N and O Donor Ligands

In last two decades vanadium coordination chemistry has grasp the interest of chemists due to its importance from catalysis and medicinal point of view. Vanadium plays significant role in different biological systems, actively serving in vanadium dependent haloperoxidase and nitrogenase enzymes. It also exhibits insulin-mimetic (anti-diabetic) activity. The present study is carried out in order to synthesize new vanadium (V) complexes with N and O donor hydrazide ligands and reveal their biological importance in terms of antioxidant activities and different enzyme inhibition activities. On the basis of spectral, elemental and physical data, synthesized vanadium (V) complexes are tentatively assigned to have an octahedral geometry with two hydrazide ligands and two oxo groups forming a negatively charged sphere complex with ammonium as counter ion. This is further verified by the conductivity studies of the complexes. In synthesized vanadium (V) complexes hydrazides act as bidentate ligands and are found to be attached with O of C=O and N of NH2, and these attachments are evident from IR and NMR spectra of these complexes. The inhibitory potential of vanadium (V) complexes of hydrazides against oxidative enzymes including xanthine oxidase and lipoxygenase is determined. In addition, non-enzymatic radical scavenging activities of these complexes were also determined. Results show that hydrazide ligands (1-12) and their respective vanadium (V) complexes (1c-12c) posses scavenging and inhibition potential against DPPH and lipoxygenase, respectively. However, contrary to that uncoordinated ligands showed no activity against nitric oxide, superoxide and xanthine oxidase whereas their complexes showed varying degree of activity. It is interesting that V(V) complexes are more active for all enzymatic and radical scavenging studies reported here except for lipoxygenase enzyme which demonstrates the difference in the interaction of metal complexes with metalloenzymes. Furthermore enzyme inhibition potential of all the synthesized ligands, metal salt and vanadium (V) hydrazide complexes has also evaluated against tyrosinase, urease and carbonic anhydrase enzymes. Results obtained during the course of this study reveal that hydrazide ligands show moderate inhibition against tyrosinase, but found to be inactive against urease and carbonic anhydrase enzymes. Vanadium (V) hydrazide complexes show variable degree i.e. excellent, moderate to weak activity against all of these studied enzymes. These studies indicate that geometry of complex, nature and position of substituent groups play a vital role in scavenging and inhibition potential of these compounds and demonstrate the difference in the interaction of metal complexes with metalloenzymes. Further pharmacological and toxicological studies are required to evaluate the bioactive vanadium complexes to find out their potential for use as drugs.
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