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استفہام کے معانی و مفاہیم
استفہام کے معانی و مفاہیم
لفظ استفہام باب فہم یفہم کے وز ن استفعال کا مصدر ہے، جس کے لغوی معنیٰ’’دریافت کرنا، سمجھنے کی خواہش کرنا،پوچھناَ ہیں۔[[1]]
ابن منظور افریقی لفظ استفہام سے متعلق لکھتے ہیں:
استفہام سے مراد "کسی چیز کو سمجھنا اور سمجھانا ہے۔"[[2]]
اصطلاح میں استفہام سے مراد ہے کہ:
"نا معلوم چیز کو ادوات استفہام سے جاننے کی کوشش کرنا"۔[[3]]
متوازن شخصیت: تعلیم و تربیت کا نبوی اصول
A child born with a soul of being, but has lack of personality. Actually personality comes with the effect of good education, guidance, squatter and environment in which a child lives. But literally due to the teachings of Hinduism or Buddhism or Christianity a human existence proves oneself with a personality. Even western civilization has an ideal concept of personality, but human personality has its very strong roots in Islamic teachings as Holy Qur’ān gives us a first-hand description about an “Ideal Personality”. According to the “Sunnah” of Prophet Muhammad (r) man has some qualities of “moderation” which can be the dominant in excess of his existence. So, man should establish equilibrium regards his personality. But there is need to create stability in education, society and politics on the basis of “moderation”. Islam lays a great emphasis on character building. Balanced personality is based on all the best qualities of head and heart. Our Holly Prophet’s (r) personality is an excellent example of balanced personality. In Islamic perspective just to accept the characteristics and Sunnah of Muhammad (r) can be equal to the modern word of personality. But have we absorbed the ultimate concept of personality? Which personality can we call an ideal personality? These two questions are very significant to wonder about on the concept of ideal personality. Every religion and civilization has its own true meaning of ideal personality, but besides all this according to Quran the ideal personality is concealed in a word “Sunnah”. The article highlights on basic characteristics of ideal personality in the light of teachings of Holly Prophet (r). Balanced and Moderate personality is the basic principle of Prophets TeachingsNiosomal Encapsulation of Anticancer Drugs and Assessment of Their Activity Through Cancer Cell Line
Niosomes are self-organizing non-ionic surfactant vesicles, which encapsulate aqueous volume of drug(s) with or without the addition of cholesterol and other lipid contents. Niosomes have the capability to encapsulate both lipophilic and hydrophilic drugs. They are alternative to liposomes, and their main benefits as compared to liposomes are their lower price, higher stability and better biodegradability. By making niosomes, the side effects of drugs have been reduced and the therapeutic efficacy has been increased. The first part of the study was to develop an optimized niosome formulation for the encapsulation of a poorly water-soluble drug by the ecological probe sonication method. Pluronic L121 and Span 60 were used as surface active agents and the optimization of the composition was made with the aid of Design of Experiment (DoE) concept. Rifampicin was used as a model drug. Concentration levels of charge inducing agent, dicetylphosphate (DCP), and Pluronic L121 were studied as variables. Prepared niosomes with varying concentrations of DCP and Pluronic L121 resulted in small sized niosomes with sizes ranging from 190 nm to 893 nm. During the four weeks stability testing, the particle sizes were reduced slightly. The formulation containing 2 mg of DCP resulted in most stable niosomes with 75.37% entrapment efficiency. All the niosomal formulations showed higher In vitro drug release rates as compared to bulk drug formulation. The rifampicin loaded niosomes prepared with Pluronic L121 and Span 60 resulted in stable, small sized niosomes with improved drug release profile. The second part of the study was carried out to produce niosome formulations for the encapsulation of a hydrophilic and poorly water-soluble drugs by the ecological probe sonication method. Pluronic L121 and Span 60 were used as surface active agents and the optimization of the composition was made with the aid of Design of Experiment (DoE) concept. Ceftriaxone sodium and Rifampicin were used as model drugs (hydrophilic and hydrophobic respectively). Concentration levels of charge inducing agent, dicetylphosphate (DCP), and Pluronic L121 were studied as variables. Prepared niosomes with varying concentrations of DCP and Pluronic L121 resulted in small sized niosomes with sizes ranging from 164 nm to 893 nm. During the four weeks stability testing, the particle sizes were reduced slightly. The formulations CR1 and CR2 resulted in most stable niosomes with (98.71% of rifampicin and 95.73% ceftriaxone) and (98.86% rifampicin and 95.88% ceftriaxone) entrapment efficiency of respective formulations. All the niosomal formulations showed higher In vitro drug release rates as compared to bulk drug formulations. The ceftriaxone and rifampicin loaded niosomes prepared with Pluronic L121 and Span 60 resulted in stable, small sized niosomes with improved drug release profile. In the third part of study, the niosome formulations were prepared for the encapsulation of anticancer drugs by the ecological probe sonication method. Pluronic L121 and Span 60 were used as surface active agents in niosomes and doxorubicin HCl and paclitaxel were used as anticancer drugs. Thorough physicochemical studies were performed for the niosomes and their cytotoxicity and activity were evaluated on MCF-7 and PC3- MM2 cancerous cell lines. Prepared niosomes were small with sizes ranging from 137 nm to 893 nm and entrapment efficiencies were high, ranging from 91.24% to 99.99%. During the four weeks stability testing, the particle sizes remained stable. The niosomal formulations showed In vitro sustained drug release profiles for doxorubicin HCL and increased clearly dissolution rate of poorly water-soluble paclitaxel. The incorporation of both the drugs into niosomes, improved cell penetration and antiproliferative activity of the drugs towards PC3 as compared to MCF-7 cell lines. As a conclusion, doxorubicin HCl and paclitaxel loaded niosome formulations resulted in relatively stable, small sized niosomes with improved drug release profiles, better cell penetration and antiproliferative activity. The niosomes showed more antiproliferative effect due to the presence of both drugs, which can overcome multidrug resistance. The present study suggested that the codelivery of anticancer drugs can be delivered by encapsulating in niosomes prepared from Pluronic L121 and Span 60. Through which improved in-vitro sustained release of both anticancer drugs, better cell penetration and antiproliferative activity. The further in-vivo evaluation can lead to treat different types of cancers in a better way without toxic effects with reduction in doses.Journals by Discipline
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