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ارمغانِ محبت درصنعت توشیح

ارمغانِ محبت
(در صنعتِ توشیح)

شہزاد
ش شاہِ طیبہ کی محبت کا سدا نغمہ گزار
ہ ہر عمل اُس کا جمالِ مصطفیؐ کا عکس بار
ز زادِ رہ اس کا فقط وصفِ حبیب کردگار
ا ایک شاعر ، اک محقق ، اک ادیبِ زر نگار
د دستِ فن سے نعت گوئی کا سلیقہ آشکار
احمد
ا اس کا ہر اک نقشِ خدمت ، آب دار و تاب دار
ح حمدِ باری ، مدحِ احمد، اُس کا عجز و افتخار
م مدحتِ خیرالبشرؐ کے گل ستاں کا نوبہار
د دانش و حکمت میں یکتا ، بزمِ فن کا شہریار!
از جمشیدکمبوہ

عصر حاضر میں مسلمانوں کی سیاسی ابتری اور اس کا تدارک: سیرتِ طیبہﷺ کی روشنی میں

The noble life Of Rasulullah (ﷺ) provides the best after course and framework for the individual and collective life of Muslims which can lead Muslims to prosper in each part of life. Out of different problems of the Muslim Ummah in the current circumstances is the absence of political insight and exemplary leadership which is one of the most important problems and due to which Muslims are victim of decline on international basis. The political and national problems of Muslims include the absence of exemplary leadership, Muslim Ummah getting victim of mutual differences, deprivation of the majority of Muslim rulers of bravery and boldness, shortage of the wellbeing of the public, excess of corruption and fraud, absence of self-accountability in the public and rulers, not complying with the rules of justice, shortage of qualified and experienced individuals in different departments and institutions along with some other similar problems. Without getting them solved, the dreams of prosperity and success of Muslim Ummah cannot be fulfilled. We can find the solution of all of these problems in the teachings of Rasulullah (S.A.W) and in his noble life. Hence it is very important to prepare a framework in the light of Seerah and adopt it accordingly in this very important part of life. In the article under reference, Muslims Political deterioration in the modern era and a review of its remedy is to be presented in the light of Seerah.

In-Silico Analysis of Nssnps Associated With Cyp11b2 Gene

CYP11B2 gene is located over the upper layer of the kidney. It produces aldosterone synthase enzyme and thereby has an essential role to balance salt and mineral level in the body. Any SNP (single nucleotide polymorphism) mutation in this gene can dis-regulate the production of aldosterone hormone in the body which may lead to many diseases including hypertension and cardiac diseases. To control the excess production of this aldosterone an inhibitor ?Fadrozole? is being used by scientists; the Fadrozole associates with an active site cavity of CYP11B2. This study has been divided into two portions; in the first phase, the four computational tools (SIFT, Polyphen-2, I-Mutant, ConSurf) were used to identify 29 deleterious SNPs out of 1600 CYP11B2 SNPs. In the second phase, five residues (R448G, R141P, W260R, F130S, and F445S) were identified in the active site cavity (out of 29 deleterious CYP11B2 SNPs) at the distance of 5Ao using PyMol. Dynamic simulation and binding free energy calculation techniques were applied to determine the effect of these mutations on the CYP11B2-Fadrozole compound. The results showed that Fadrozole binding becomes stronger with CYP11B2 with these mutations which proved the efficiency of this drug inhibitor with these highly damaging mutations. This study narrows down the large dataset of CYP11B2 SNPs and identifies 29 deleterious SNPs as well as it validate the fadrozole inhibitor efficiency for cavity residues
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