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۱۔ دستِ فراخ

دست ِ فراخ

میں وہ تیرگی ہوں

 جس کے واسطے

آسماںکو چیرتے

اک نورِ عظیم سے

دشت کی وسعتیں چمک اٹھیں

پہاڑوں کو چوٹیاں دمک اٹھیں

میں وجہِ قیام ِطویل ہوں

کہ شب بھی رو پڑے

 خدا بھی پکار اٹھے

 بس کیجیے !بس کیجیے

میں وہ خاکِ خوش نصیب ہوں

جس پہ تحائفِ سماوی کا نزول ہے

میں آنسوئوں سے تروہ دعا ہوں

جسے ازل سے اندیشہ ٔ رد نہیں

جو فقط قبول ہے،قبول ہے

 میں وہ غم ِ بختیار ہوں

جسے دلِ اطہر کی پناہ ملی

 وہ راہ نور ہوں

جسے روشن نگاہ ملی

بس اب اتنی ہے آرزو

پاک فضا میں سانس لوں

زمزم میرا مشروب ہو

سایۂ سبز تلے پڑا رہوں

اور جب ہو عالمِ تشنگی

 ساقیِ دو جہاں کے دستِ فراخ سے

وہ جامِ تمنا نصیب ہو

جس کی سدا تمنا رہی

The Tradition of Innovation in Islamic Civilization: An Exclusive Study of Early Ages of Islam

اسلامی تہذیب میں تازہ کاری کی روایت: قرون اولی کا اختصاصی مطالعہ Islamic civilization was founded by the Holy Prophet (May blessings of Allah and peace be upon him) right from the beginning of Islam. Each civilization and every culture are deeply affected by the concurrent cultures and civilizations and it used to adopt and borrow many things from other civilizations. Similarly, Islamic civilization and culture borrowed many aspects from other prevailing civilizations. With the passing day, these intercultural relations and exchanges became the part and parcel of the Islamic civilization. Such communications, and they have marked all epochs in Islamic history, occur in greatly diverse ways. The Holy Prophet also approved some traditions in this regard and the four Caliphs adopted many customs too. This reflects the adoption and concluding from other civilizations is not prohibited in every case, but this adoption must not be against Islamic teachings. Now a days, the entire world has become a worldwide town because of internet and technological developments. It is relatively obvious that Muslims are adopting many things from western civilization and culture without knowing its legitimacy or illegitimacy. Resultantly, these activities apparently become the chunk of Islamic civilization. This investigation seeks guidance from golden period of Islam i.e. Early centuries of Islam and describes its validity or voidness. In this article, these experiences of Islamic civilization and culture in adopting and concluding from other civilizations and cultures have been conferred and their principles and opinion of the prominent scholars, in this context, been talked about in the light of Islamic teachings. This study will promulgate awareness about the tradition of innovation in Islamic civilization and will provide guidance to the new researchers about this topic.  

Immunoprophylactic Potential of Anti-Idiotype Foot-And-Mouth Disease Vaccine

The present study was designed to develop an anti-idiotype foot-and-mouth disease antigen for the evaluation of immunoprophylactic potential. Three serotypes of foot-and-mouth disease virus were procured from the veterinary research institute, Peshawar. Re-characterization of the virus was done through PCR and further serotyping was performed by indirect sandwich ELISA (IsELISA). The inactivated three serotypes of the virus were injected in goats for the preparation of idiotype antibodies (IgG). The goat serum containing 90% idiotype antibody titre was processed for separation of idiotype antibodies through Octanoic acid-ammonium sulfate precipitation method. Idiotype was purified and the fragment antibody binding (Fab) component was separated through pepsin digestion that was analyzed through SDS-PAGE. The protein concentration of Fab was adjusted to 5 mg/mL and 10 mg/mL. Fab of IgG was emulsified in MONTANIDE™ ISA 206 VG and the prepared idiotype antigen suspension was injected into two groups of the layer birds. The eggs were collected and the presence of anti-idiotype antibodies in the egg yolk was confirmed through agar gel immunoprecipitation test (AGPT). The diluted egg yolks were processed for the separation and purification of anti-idiotype antibodies through ammonium sulfate precipitation technique. The purified IgY proceeded to pepsin digestion and Fab component was obtained. Fab of anti-idiotype antibody, after digestion, were analyzed through SDS-PAGE and the protein concentrations were adjusted to 10 mg/mL. The Fab of IgY was emulsified in Montanide (1:1) and the anti-idiotype FMD antigen was injected as a surrogate antigen for FMD virus in mice and calves. Sterility, safety and stability studies of anti-idiotype FMD antigen were performed. Immune response of Montanide adjuvanted monovalent and trivalent anti-idiotype FMD antigen was determined in mice. The comparative immune response of Montanide adjuvanted trivalent anti-idiotype FMD antigen and trivalent FMD commercial vaccine was done in mice and calves. The comparative mean antibody titre was determined through least significant difference followed by factorial analysis. Foot-and-mouth disease virus was detected through PCR at 131 bp. Is-ELISA confirmed three serotypes of Foot-and-Mouth Disease virus, Asia 1, A and O, at OD value < 0.1 at 1/10th dilution. The AGPT results indicated early development of anti-idiotype antibodies in layer birds injected with 10 mg/mL Montanide adjuvanted idiotype antigen. The development of antiidiotype antibodies in egg yolk was detected within 18 hrs of incubation on day 14 from the last injection. At day 45 post-immunization (PI) in mice, Montanide adjuvanted monovalent antiidiotype FMD antigens produced initial antibody titre of 78.80%, 81.30% and 81. 20% for serotype A, Asia 1, and O respectively. The antibody titre decreased to 78.10%, 79.50% and 78.90% respectively at day 60 PI. The more stable immune response against serotype A was recorded at day 60 PI. Montanide adjuvanted trivalent anti-idiotype FMD antigen in mice produced highest antibody titre of 81.60% at day 45 compared to Montanide adjuvanted FMD vaccine that produced titre of 77.50% at day 45 PI. A slow decrease of 1-2% in antibody titre of Montanide adjuvanted trivalent anti-idiotype FMD antigen in mice at day 60 was recorded. The immune response of Montanide adjuvanted trivalent anti-idiotype FMD antigen in calves was persistently 80% while titre of Montanide adjuvanted FMD vaccine decreased to 74% at day 60 PI.
Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

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