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پروفیسر مغنی تبسم

مظہر امام /پروفیسر شہریار/پروفیسر مغنی تبسم
افسوس اس ماہ فروری میں اردو کے آسماں پر درخشاں، چند ستاروں کے چھپ جانے سے اردو دنیا کی رونق میں کمی آگئی، جناب مظہر امام ، پروفیسر شہریار ، پروفیسر مغنی تبسم یکے بعد دیگرے رخصت ہوئے، مظہر امام کی شناخت آزاد غزل کے حوالے سے ہے، کئی شعری اور تنقیدی کتابوں کے مصنف تھے، پروفیسر شہریار اور پروفیسر مغنی تبسم، ہندوستان کی دو ممتاز جامعات یعنی مسلم یونیورسٹی اور جامعہ عثمانیہ میں اردو کے کامیاب اور نامور استاد ہی نہیں، شعرو ادب کی دنیا میں صاحب مرتبہ و مقام بھی تھے، شہریار کی شہرت گو ان کی زندگی کے دور آخر میں خوشبو کی طرح عام ہوئی لیکن نشاط غم اور رنج شادمانی کے مختصر اور فانی لمحات کا ساتھ عمر بھر رہا، ان کی شہرت کے شہپر جب سمٹے ہوئے تھے اس وقت بھی انہوں نے اس خاموشی کو بلیغ معانی دیے تھے، خواب، رات، دیار، پرچھائیں، سفر، تشنہ لبی کے پردے میں وہ دیار دل اور بزم دوستاں تلاش کرتے رہے، مغنی تبسم شہریار کے پیشہ تدریس میں ہی شریک نہیں رسالہ شعرو حکمت میں بھی برابر کے سہیم تھے، وہ حیدرآباد کے دائرہ ادبیات اردو اور رسالہ سب رس سے مدتوں وابستہ رہے، فانی بدایونی پر تحقیق کی تھی، درجنوں کتابیں لکھیں، عجیب بات ہے کہ ادبی سفر میں مغنی تبسم اور شہریار ساتھ ساتھ رہے، ابدی سفر میں بھی یہ رفاقت قائم رہی، شہریار کے نام ایک خط میں مغنی تبسم نے لکھا تھا کہ ’’شاعری تو ایسی چیز ہے جو خدا، انسان اور کائنات کے درمیان پچھلی راتوں کا دعائیہ بن جاتی ہے، کتنے لوگ ہیں جوان ساعتوں میں دست دعا دراز کرتے ہیں‘‘، مغفرت کے لیے کوئی عمل یا کوئی قول کام آسکتا ہے، ہمارا دست دعا بھی اسی لیے دراز ہے۔...

EFFECTS OF BOWEN THERAPY IN PATIENTS WITH TENSION-TYPE HEADACHE: A RANDOMIZED CONTROLLED TRIAL

Background and Aim: Bowen therapy is a non-pharmacological method for treating a variety of pain conditions, but its effectiveness in treating tension-type headaches is unknown. We compared the effectiveness of Bowen therapy to a sham treatment. Methodology: In a multi-center randomized controlled trial, the young adults with a tension-type headache were selected from the Neurology Department of DHQ hospital Sargodha and Niazi Medical Complex, Sargodha, with convenient sampling. A priori sample size calculation determined that 44 participants were needed. The participants were randomly assigned to two groups. Bowen Therapy (n=22) and Sham Treatment (n=22) groups were enrolled. The Bowen therapy was devised for two weeks. The measurement was taken at baseline and after two weeks. SPSS 22 was used for data analysis. Results: At baseline, there was no difference found in the Bowen therapy and Sham treatment groups. We have noticed a significant decrease in the severity of pain and improvement in pain pressure threshold assessed by the visual analogue scale (VAS) and algometer in the Bowen therapy group after two weeks (<0.05). However, no changes in pain intensity were found in the sham therapy group. Furthermore, the headache frequency was also reduced in Bowen therapy compared to the sham therapy group (<0.05) after the study period. Conclusion: The findings suggest that Bowen Therapy might be a beneficial and effective treatment for a tension-type headache. Further studies are needed using older adult’s participants.

Leptin Gene Polymorphism in Nili-Ravi Buffalo Bulls and its Correlation With Male Reproductive Traits

Genome analysis in animals has introduced new criteria for animal selection and strategies for increasing herd productive and reproductive potential through breeding. Leptin gene has established as a potential candidate for marker assisted selection of animals. The present study was aimed to investigate polymorphism in leptin gene of Nili-Ravi buffalo breeding bulls and its relationship with physical characteristics and reproductive traits for genotyping of breeding bulls. For this purpose, blood samples from 99 buffalo breeding bulls were collected for DNA extraction by using standard organic protocol. Primers for the amplification of leptin gene sequence were designed by using primer3 software (v. 0.4.0). Sequence comparison of leptin gene revealed, a total of 33 SNPs out of which 13 SNPs were found in the region of exon 2 and 3. While twenty (20) SNPs were found in intronic regions. To author’s knowledge three (3) SNPs at positions c.68, c.70 and c.158 in exon regions of leptin gene have been reported first time in buffalo. Analysis of variance and Pearson’s correlation was applied using R-statistical package (v. 2.15.2) for analysis of data. Results showed that the SNP at position c.20-91 had significant (p<0.01) positive correlation with dead sperm percentage, while it showed a negative correlation (p<0.05) with live weight of buffalo bulls, length from shoulder to pin-bone, individual sperm motility and live sperm percentage in the ejaculate. Leptin gene polymorphism at c.20-91 position significantly (p<0.01) affect ejaculatory volume and sperm motility after dilution. The single nucleotide polymorphism at position c.20-41 showed positive correlation (P<0.05) with girth, scrotal circumference and dead sperm percentage, while it was negatively correlated with sperm concentration and live sperm percentage. The c.20-27 polymorphism showed negative correlation (P<0.05) with age of buffalo bulls, live weight of bulls, length from shoulder to pin-bone, girth, scrotal circumference and testicular length of bulls. Effect of c.20-27 polymorphism on the distance between angles of the hip was also found significant (p<0.01) through analysis of variance (ANOVA). The polymorphism at position c.20-21 showed positive correlation (P<0.01) only with the live weight of buffalo bulls. The C>T change at position c.191+19 was positively correlated (P<0.05) with scrotal circumference and reaction time. Analysis of variance revealed significant effect of c.191+19 polymorphism on sperm motility after dilution. The SNP at position c.191+30 was found positively correlated (P<0.05) with body condition score and reaction time. Analysis of variance also verified its significant effect on the length from shoulder to pin-bone. The SNP at position c.191+41 revealed positive correlation (P<0.05) with live sperm percentage, while it was negatively correlated with dead sperm percentage. Similarly its effect on the distance between angles of the hip was significant (P<0.01) through analysis of variance. The genetic variant at position c.191+51 was positively correlated (P<0.05) with reaction time, while its correlation was negative with the live weight of buffalo bulls. Analysis of variance also showed significant (P<0.01) effect of c.191+51 SNP on the number of mounts per ejaculate. The c.191+99 SNP had a positive correlation (P<0.05) with live weight and live sperm percentage, while, it was negatively correlated with dead sperm percentage. Moreover, analysis of variance also confirmed its significant (P<0.01) effect on the number of mounts per ejaculate. The polymorphism at position c.284 was found to be negatively correlated (P<0.05) with length from shoulder to pin-bone and sperm motility after freezing. The c.422 polymorphism revealed significant positive correlation (P<0.05) with the height at withers, distance between angles of hip, scrotal circumference and testicular length. Analysis of variance also showed significant (P<0.05) effect of c.422 polymorphism on width of the face above eyes. However, the genetic variant at position c.523 showed significant negative correlation (P<0.05) with various parameters such as height at withers, length from shoulder to pin-bone and sperm motility after freezing. In conclusion, findings of present study suggests leptin gene to be a highly polymorphic with a significant correlation with different physical, reproductive performance and semen quality parameters in Nili-Ravi buffalo bulls. These SNPs can be considered as genetic markers.
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