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خالد مسعود

آہ جناب خالد مسعود!!
یہ خبر علمی و دینی خصوصاً ترجمان القرآن مولانا حمید الدین فراہیؒ کے قدردانوں اور ان کے علوم و افکار کے شیدائیوں کے لیے بڑی غم ناک اور روح فرسا ہے کہ یکم اکتوبر ۲۰۰۳؁ء کو رسالہ تدبر لاہور کے مدیر جناب خالد مسعود صاحب کا انتقال ہوگیا، اناﷲ وانا الیہ راجعون۔
وہ مولانا امین احسن اصلاحی کے شاگرد رشید اور علمی وارث و جانشین تھے، انہوں نے اپنی زندگی فکر فراہی کی شرح و ترجمانی اور اس کی ترویج و اشاعت کے لیے وقف کردی تھی، ان کی وفات سے ہم قرآن و حدیث کے ایک بڑے خدمت گزار سے محروم ہوگئے۔
مرحوم کو جگر کی بیماری تھی، خون کی رگ بار بار پھٹ جاتی تھی اور خون کی قے ہونے لگتی تھی، آخر اس بیماری نے ان کا کام تمام کردیا۔
خالد مسعود صاحب ضلع جہلم کے ایک گاؤں ’’ﷲ‘‘ ۱۶؍ دسمبر ۱۹۳۵؁ء کو پیدا ہوئے، یہیں ابتدائی تعلیم حاصل کی اور ۱۹۵۱؁ء میں نوشہرہ سے فرسٹ ڈویژن میں میٹرک اور ۱۹۵۵؁ء میں اسلامیہ کالج لاہور سے فرسٹ ڈویژن میں بی۔ایس۔سی کیا، ۱۹۵۷؁ء میں پنجاب یونیورسٹی سے کیمسٹری میں ایم۔ایس۔سی کیا، ۱۹۵۸؁ء میں انڈسٹریل ریسرچ لیبارٹریز سے وابستہ ہوئے پھر مزید تعلیم کے لندن گئے اور ۱۹۵۹؁ء میں وہاں کے کنگز کالج سے کیمیکل انجینئرنگ میں ڈپلوما حاصل کیا، واپسی کے بعد ۱۹۷۴؁ء میں پنجاب یونیورسٹی سے علوم اسلامیہ میں ایم۔اے کیا، ۱۹۸۵؁ء میں قائداعظم لائبریری میں ملازمت کی، اس ے وابستگی کے زمانے میں بچوں کے لیے آسان زبان میں متعدد مفید اور معلوماتی کتابیں تحریر کیں، جو بہت مقبول ہوئیں اور بعض پر ان کو ایوارڈ بھی ملا، گو ان کتابوں میں فلکی طبعیات کی جدید ترین تحقیقات کے نتائج اور کائنات کے بارے میں نئے افکار و نظریات پیش کیے گئے ہیں تاہم اسلامی نقطہ نظر کو اوجھل...

ظاهرة تزويج القاصرات من منظور شرعي

According to traditional-religious-culture the early age marriages are very common custom especially in rural areas. The act of marring girls in early ages is considered to be a good practice in these constituencies; in contrast, the holy Quran has provided some logical guidelines to reject this idea. In the holy Quran “men” are instructed to marry as per their choice, which reveals, it is necessary for a “man” to be adult (Baligh) for marriage. Considering this fact, how it is possible that a man can be permitted to have a non-adult (Nabaligh) life partner? In this regard, marriages between Adult and Non-adult, Non-adult and Non-adult are not permitted because it is against the right of equality. Further, the holy Quran instructs the guardians of the orphans to return them their valuables when reach to the age of Nikah; which reveals that there is a particular standard of age set for Nikah, if it is not so, why the holy Quran has made this bounding for the guardians of the orphans? As per the guidance of the holy Quran, it is clear that Nikah requires both man and women not only to be physically adult/mature but also mentally adult/mature. In this connection, it has been highlighted that Nikah which is a physical contract requires a particular age for man and woman which however cannot be an age of Non-adult.

Modulation of Proliferation and Apoptosis Biomarkers in Oral and Other Cancers

Cancer, also known as neoplasia, involves uncontrolled cell proliferation leading to malignant tumor formation. Epithelial cancers (or carcinomas, representing about 80% of all cancers) are a group of cancers originating in the epithelial lining of many locations, such as digestive tract, airways, breast, reproductive tracts and oral cavity. Oral cancer is one of the eight most common types of cancer worldwide. It starts from the upper digestive tract, including the larynx, oral and nasal cavities. Whereas lung cancer is the major cause of cancer-related deaths worldwide, representing about 26% to 28% per year. Heavy alcohol consumption, betel nut chewing, smoking, viral infections, occupation hazard and exposure to UV radiation are the major risk factors. Tyrosine kinase receptors (TKs), such as EGFR and Lyn are major regulators of cell growth and survival. In cancer cells, such receptors are constitutively activated and lead to malignant phenotype. Blocking of active TKs efficiently stops proliferation and induces apoptosis in oral and lung cancer cells. In the present study, we selected five TKIs (Genistein, Gefitinib, Erlotinib, Dasatinib, and Imatinib) which acts upon EGFR and Src family tyrosine kinases. Imatinib and Dasatinib are non-optimal TKIs for oral and lung carcinomas, and have to be utilized at relatively high concentrations to display inhibition. Our goal was to select therapeutically suitable small molecules, such as resveratrol (a natural polyphenol) and artemisinin along with its derivatives (synthetic endoperoxides) to potentiate the sub-optimal activity of standard TKIs. The objective of our study was to investigate standard TKIs and the possible adjuvant effects of artemisinin derivatives (endoperoxides, EPs) and resveratrol (natural phenol, NP) on highly malignant lung cancer cells (NCI-H460) and laryngeal cancer cells (KCLB-SNU46) of lower malignancy. Optimal combinations of TKIs and EPs/NP that decrease the proliferative capacity of oral and lung cancer cell lines, and increase their apoptosis potential were thus investigated. The techniques employed were flowcytometry, spectrophotometry, SDS-PAGE and western blotting. Out of five TKIs, Imatinib and Dasatinib at higher concentration and on 48 hours incubation affected the oral cancer cell line (KCLBSNU46). However, the lung cancer cell line (NCI-H460) responded to Gefitinib as well as Imatinib and Dasatinib only after 48 hours. Artemisinin itself didn’t show any effect but its endoperoxide derivatives OD59 and OD66 showed potent anticancer activity (with very low IC50) in both cell lines when compared to that of the standard TKIs. Resveratrol showed no effect on oral cancer cells, but lung cancer cells did respond to high resveratrol concentrations. In combination studies, resveratrol and endoperoxides (OD66 and OD67) showed significant synergistic effects when combined with gefitinib and dasatinib at very low concentrations in both the cell lines. Furthermore it was confirmed that these synergistic combinations induced apoptosis by modulating the phosphorylation of the EGFR and Lyn tyrosine kinases. This study conclude that resistance phenomena in cancer cells can be modulated by combining sub-therapeutic doses of standard TKIs with least effective doses of natural and synthetic compounds. This approach can conveniently reduce the dosage as well as the cytotoxic effects of the clinically used TKIs on cancer patients.
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