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مرثیہ: حضرت بابا یونس صابری سرکار

مرثیہ حضرت شاہ محمد یونس صابری سرکار
( آستانہ عالیہ صابریہ ملتان شریف)

تیرا ہے احسان زمانے تھے بابا یونس لکھ ہزار
تیرا قرض ادا نہ ہو سکیا جہڑا ویکھیا سی تساں پہلی وار
اساں خوشیاں دے وچ بھل گئے
تہاڈے باجھوں سوہنیا رل گئے
تساں چھوڑا سانوں جل گئے
اسیں روندے پئے ہاں زار و نزار
در تیرے آکے قرار ملے
تیرے جیا نہ کدھرے پیار ملے
نہ ایہہ جیا کوئی وفادار ملے
گلی کوچہ ڈھونڈیا ہر بازار
کوئی ایڈا قاصد آیا جہدے اگے پیش نہ جاندی اے
مرن توں پہلے مرگئے انہا نوں موت کدے نہ آندی اے
کم ویکھ قضاء قدر دے بناں سجناں سنج ہو جاندی اے
سنجی پئی حویلی سانوں دسدا نہ سوہنا یار

تساں چھڑ کے سانوں ہے کتھے ڈیرا لایا
اساں روندے نیر وہاندے رہے
تہاڈے ہجر فراق اندر اسان رورو ہوش گنوایا
سوہنے مکھ نورانی والی سانوں جھلک دکھا ہک وار
تہاڈے باغ باغیچے تے پھل بوٹے پئے مہکدے ہر ہر جائیں
محفل خانیاں تھیں ذکر اذکار دیاں پیئاں ہون بلند صدائیں
جہڑی راہ وکھالی اسی ٹر دے اسے راہیں
پر تہاڈی جدوں یا دستاندی نین ہوجاندے اشکبار
قادری سائیںؔ یونس بابا جی ٹرگئے پر یاد انہاندی ریہہ گئی
چار چوفیرے پین بھلیکھے پر دل وچ صورت بہہ گئی
ایڈا دکھ وچھوڑے والا نال صبر دے جندڑی سہہ گئی
وچھڑے یار نہ بھلدے بھاویں گزرن سال ہزار

سنت كى آئينى حيثيت اور اقبال

The personality of Allama Iqbal is the integral part of the religious and national thinking of the Muslims of subcontinent,  and for Pakistanis along with a religious thinker he is also the person who gave the idea of Pakistan. Because of this legacy Iqbal is considered as the founder of a school of thought in Pakistan's academic atmosphere. The magnitude of this position and importance is evident from the fact that the people of different intellectual backgrounds and ideologies have been seeking evidence from Iqbal in support of their arguments. So even the proponents of socialist ideology or the holders of the thought of negating the legal status of Hadeeth have tried to prove Iqbal as a torch bearer of their stance and saw their struggle as a continuation of his (Iqbal’s) thinking. But it is a general rule that a person, especially the one who is a prominent figure and there are a lot of themes that are present in his thoughts, cannot be judged on the basis of only some of his works. So declaring Iqbal as the negator of legal status of the Hadeeth because of some of his writings is not a fair academic activity. This paper would study the actual view of Iqbal about the legal status of Sunnah as well the place of Prophethood in his thoughts and try to figure out whether his stand in this regard is in accordance with the traditional concept o1r it is different and if it is different then how much is it different?

Study of Inhibition of Carbonic Anhydrase Ii and Dpp-Iv As Possible Targets of Drug Discovery

Research on enzyme inhibitors has an enormous potential to introduce new drug candidates against enzyme related diseases. Keeping this in view, present study was designed to identify natural and synthetic compounds as leads against two clinically important enzymes, carbonic anhydrase-II (CA-II) and dipeptidyl peptidase-IV (DPP-IV). Carbonic anhydrases (CAs), and dipeptidyl peptidase-IV (DPP-IV) have pathological roles in the emergence of number of diseases, particularly glaucoma and diabetes, respectively. The results of the study are summarized below: PART A CA-II is an important enzyme for many physiological processes. Inhibitors of CA-II are used for the treatment of many diseases, such as epilepsy, mountain sickness, and glaucoma. During this study, over 350 fully characterized compounds were evaluated against BCA-II enzyme. Out of which 58 compounds showed a good inhibitory activity. Among these compounds, bisindoles and thiourea derivatives of bisindolyl showed the most significant activity with IC50 values in the range of 14.4 – 70.36 μM. To study the mechanism of action of inhibitors, most active inhibitors of these classes were further subjected to kinetic studies. Inhibition constants and type of inhibition were deduced by using Lineweaver-Burk plot, secondary re-plot of Lineweaver-Burk plot, and Dixon plot. Inhibition type and dissociation constants were deduced by Lineweaver-Burk plot, secondary re-plot, and Dixon plot. Bisindole derivatives, such as 23 (N-(4-(bis(5-chloro-1H-indol-3-yl)methyl)phenyl)-2,4-dinitrobenzenesulfonamide), 28 (N-(4-(bis(5-chloro-1H-indol-3-yl)methyl)phenyl)-3,5-dichloro-2-hydroxybenzenesulfonamide), and 38 (N-(4- (bis(5-bromo-1H-indol-3-yl)methyl)phenyl)-2,4-dinitrobenzenesulfonamide) showed a significant inhibition of enzyme CA-II (IC50 = 15.6 – 28.86 μM). To assess their safety profile, cytotoxic studies were conducted on mouse fibroblast cell line (3T3). Fortunately some of the good active compounds were found non-cytotoxic, and thus can serve as leads for further studies on CA inhibitor drug design and development. PART B Epidemic prevalence of diabetes at national and global level emphasizes the need of urgent therapeutic intervention. In the second part of our work, we targeted an important enzyme of incretin pathway, dipeptidyl peptidase-IV (DPP-IV). Inhibitors of DPP-IV occupy center stage in the current anti-diabetic drug market. We screened over 1,800 fully characterized natural and synthetic compounds, through a mechanism-based colorimetric assay. This led to the identification of 87 new inhibitors. Significant inhibition was shown by the compounds of semicarbazones, thiosemicarbazone, benzophenone Schiff bases classes, and gold complexes. New inhibitors, identified through initial screening, were further subjected to mechanism-based kinetic studies. Lineweaver-Burk plot, secondary re-plot of Lineweaver-Burk plot, and Dixon plots were constructed to determine the type of inhibition, inhibition constant, and other kinetic parameters. Cytotoxic studies of active compounds were also conducted on mouse fibroblast cell line (3T3). Some potent inhibitors were also subjected to in situ DPP-IV inhibition assay by using Caco-2 cellular model. Synthetic compounds of different classes and Gold complexes were found to be active. Compounds (R)-2-phenyl-2,3-dihydrobenzo [d] imidazo[2,1-b] thiazole gold (I) triphenylphosphine tetrafluoro borate (204), (S)-2-phenyl-2,3-dihydrobenzo[d]imidazo [2,1-b]thiazole gold (I) triphenylphosphine tetrafluoro borate (207), and (S)-2-phenyl-2,3-dihydrobenzo[d] imidazo [2,1-b] thiazole gold (I) chloride (209) were identified as most potent inhibitors with IC50 values in the range of 22.0 – 35.6 μM. Earlier studies on DPP-IV inhibitors were restricted to selected number of compounds with limited structural variations. Present study presents comprehensive screening of different classes of synthetic compounds for the discovery of new inhibitors of DPP-IV. This is a cost effective, easy, reliable, and fast approach for the discovery of new drug candidates.
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