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Muhammad - The Recipient of The Qur’an

Muhammad -
The Recipient of The Qur’an

Muhammad was the only child of his parents – Sayyed ‘Abd-Allah bin ‘Abd Al-Muttalib Al- Hashemi and Sayyedah Aminah bint Wahb Al-Zuhriyya. He was born in Makkah, a commercial metropolis and a pilgrims’ hub in the Arabian Peninsula. His father passed away before his birth, and the mother when he was six. A shepherd in early life and a successful merchant in adulthood, he married Sayyedah Khadijah bint Khuwaylid at the age of 25. The happy couple became the parents of two sons and four daughters.

Muhammad ibn Abd-Allah was reputed to be a friendly and trustworthy gentleman with an impeccable character. He was admired for his generosity as well as his wisdom. The mutually hostile factions often called upon him to act as an arbiter. At home, he was known for his caring and helpful attitudes.

As he was attaining maturity, he was getting deeply disturbed by the social and moral environment around him. He found the idolatry and fetishism unholy and social injustices distressing. He increasingly began to search for a response to his own agony at the injustice and chaos around him by resorting to meditation and seclusion. He would go away from home for several days in a row and stay in a small cave on Mount al-Noor, it is a cave hiding in shyness and seclusion with a difficult access, named Hira.

One midnight, during the last week of the month of Ramadan that the Cave lightened up. It witnessed the presence of rows over rows of angels led by the Arch Angel, Gabriel. Muhammad got bewildered. It brought him awe, fear and foreboding. It was an experience unique of its kind; unique...

ولادت النبیﷺ سے متعلق سیرۃ کی چند روایات کا تحقیقی جائزہ

Allah sent Hadrat Muhammad (SAW) as last Prophet and preserved his all aspect of life for the complete guidance of mankind. Love with the Holy Prophet (SAW) is a part of the Faith. But it has become the standard of his love that all the things which are attributed to him either authentic or unauthentic are accepted without research. Regarding the S╚rah (life) of Holy Prophet (SAW) numerous authentic narrations are exist, but on the other hand some fabricated narrations also mentioned by the story-teller historians, so be careful while propagating these narrations. Some narrations are very famous regarding the birth of the Holy prophet (SAW) which are far away from the reality. In this article some narrations regarding the birth of the Holy prophet (SAW) are scholarly reviewed in the light of the views of the scholars of Jarh-o- Ta‘d┘l in order to find their legal status.

Study of Genetic Polymorphism in Diabetes Mellitus

Diabetes Mellitus (DM) is an advanced and chronic endocrine disorder characterized by insufficiency of insulin secretion from pancreatic beta cells or of insulin resistance in peripheral tissues such as liver, adipose tissues and skeletal muscles. Glucokinase (ATP: D-glucose-6-phosphotransferase; GCK), initiates glycolysis and acts as a glucose sensor and metabolic signal producer in liver and pancreas. The present study investigated differences in allelic frequencies between 60 individual diabetics with typeII and 60 healthy controls. Clinical manifestations identified, GCK gene was selected analyzed data were compared to RFLP of the glucokinase gene and results confirmed about mutation. There were also significant differences (P<0.0001) in glycation levels (0.90, 0.4838mole/mole), random blood sugar (348.8, 105.8 mg/dl), cholesterol levels (235.3, 161.8 mg/dl), low density lipoprotein in diabetic subjects (155.3, 28.46 mg/dl) and in healthy donors. GCK gene mutations were found in 70% of the patients while 30% are non-mutated. The basic aim of this study is to understand the mechanism and genes which are responsible for the prevalence of diabetes and to investigate new trends and methods used for the treatment of this disease. A hereditary variation of a gene is mentioned in this study, it is a change in a nucleotide sequence with an addition, deletion, or investment of a nucleotide sequence. In particular, genetic variation in a gene includes a single nucleotide polymorphism. Samples show the mutation insertion, deletion and insertion/deletion. PCR-sequencing showed qualitative differences in diabetic patients in comparison to non-diabetics. Glucokinase is the most important component in glucose detection of pancreatic islet beta cells in diabetes because glucokinase mutations can be one of the most common single gene disorders described. It is known that a genetic variation of a human glucokinase gene, including a point mutation, causes MODY, concentration of plasma glucose increased and it is supposed to be the cause of diabetes of the present study subjects. The main aspects of the work were designed to investigate immunological cross-reactivity between viral antigens and pancreas-specific self-antigens. This is to investigate, hypothesis that type1 diabetes may be triggered following infection with commonly occurring viruses such as coxsackie B, rotavirus, rubella, mumps and cytomegalovirus. The ANOVA of peripheral blood CD3+ T cells in healthy controls expresses higher level (1.475 ± 0.2930), than the diabetic patients (0.685±0.0927). CD14+ T-cell on monocyte1 frequency were analysed by flow-cytometry in the same Diabetes Mellitus patients expressing the higher level in healthy control (10.79±9.225) when compared to diabetic subjects (2.615±0.5850) and CD14+ on monocyte2 in healthy subjects’ level is higher (11.41±9.925) as compared to the diabetes (2.415±1.575). B-Cell marker CD19+ in healthy donors show higher significant level (5.085±5.055) and in diabetic subjects it is comparatively lowers (3.615±1.825). In conclusion, this study proved that oxidative stress increases the production of ROS causes the hyperglycaemic control stimulates the failure of different cells like lymphocytes subsets ultimate causes the cell death.
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