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مولوی ضیاء الحسن علوی

ضیاء الحسن علوی مرحوم
افسوس کہ میرے رفیق قدیم اور صدیق حمیم مولوی ضیاء الحسن صاحب علوی ندوی نے ایک مختصر علالت کے بعد ۱۴؍ جون ۱۹۴۵؁ء کو الہ آباد میں جہاں وہ عربی مدرسوں کے انسپکٹر اور مشرقی امتحانوں کے رجسٹرار تھے ستاون برس کی عمر میں وفات پائی، اس حادثہ کی اطلاع مجھے ۱۸؍ جون کو لکھنو میں اسی مدرسہ میں ملی جہاں میں اور مرحوم مل کر ایک جان دو قالب ہوئے تھے، افسوس کہ ایک قالب خالی ہوگیا، اور دوسرا نیم جان موجود ہے، مرحوم مجھ سے عمر میں تقریباً پانچ برس چھوٹے (گو تعلیم کے درجہ میں وہ ایک سال بڑے تھے) اس لئے بظاہر امید یہی تھی کہ انہی کو میری جدائی کا صدمہ برداشت کرنا پڑے گا، مگر تقدیر یہی تھی کہ مجھے ان کے فراق کا غم سہنا پڑے اس لئے امید غلط ثابت ہوئی، اور تقدیر کا فرمان نافذ ہوکر رہا۔
اکنوں چہ تواں کرد کہ تقدیر چنیں بود
مرحوم کا کوری ضلع لکھنؤ کے مشہور علوی خاندان کے چشم و چراغ تھے، دارلعلوم ندوۃ العلماء کے حامیوں بلکہ بانیوں میں رؤساء کا جو طبقہ شامل تھا، ان میں منشی محمد اطہر علی صاحب مرحوم کا نام بہت جلی ہے، یہ خاندان قطب وقت حضرت مولانا شاہ فضل الرحمان صاحب گنج مراد آبادی رحمتہ اﷲ علیہ کا ارادتمند و معتقد تھا، جو ندوہ کی تحریک کے روحانی مرکز و مدار تھے، اس لئے جب ۱۸۹۸؁ء (۱۳۱۶؁ھ) میں لکھنو میں ندوہ کا دارالعلوم کھلا تو منشی صاحب مرحوم نے اس درس گاہ کو اپنے سب سے چھوٹے بچے اور ایک ننھے بھتیجے کو نذر کیا، یہی ننھا بھتیجا مولوی ضیاء الحسن صاحب علوی ندوی تھے، دارالعلوم کے طلبہ کے داخلہ میں ان کا نمبر شاید دوسرا تیسرا تھا، عربی کی پوری تعلیم یہیں حاصل کی اور یہیں سے فراغت...

زرتشت ازم کے شعائر، رسوم اور روایات: اسلامی تناظر میں اجمالی جائزہ

Zoroastrianism is an ancient Iranian religion founded by an Iranian Prophet and scholar Zoroaster. It is claimed by some foremost scholars that this is the most ancient religion of the world which influenced the other major religions of the world like, Judaism, Christianity and Islam. The main source to know the Zoroastrianism is Avesta, Denkart and Bundahishn (sacred books) from which we know the terminologies and traditions of this religion. Main two spirits are Ahura mazda (god of pleasure and goodness) and Ahriman (god of evil) and seven more main spirits which are called as angels are Amesha spentas which show the actual spirit and direction of this ancient religion. Some of the concepts and traditions are same which exists in Islam but with different names and features, like prayers and matters after death, heaven and hell. In this article, main focus is on tradition and terminologies of this ancient religion to know its actual spirit to get the basic information and main themes for initial reader of this religion from Islamic theological pers-pective. No doubt, Zoroastrianism is one the amended religions exist on earth yet because of the similarity of various rituals with Islam. However, Zoroastrianism is being considered reve-aled religion and Zoroaster as true prophet of Allah.

Development and Characterization of Polymer Based Nano-Doxorubicin Delivery System for Cancer Therapy

This study was aimed to develop doxorubicin loaded quaternary ammonium palmitoyl glycol chitosan (DOX-GCPQ) nanoformulation for DOX delivery and non-invasive monitoring of DOX accumulation and biodistribution at tumor site utilizing DOX’s self-florescent property. DOX-GCPQ amphiphilic polymeric nanoformulations were prepared and optimized using artificial neural network (ANN) and characterized for surface morphology by atomic force microscopy, particle size with polydispersity index (PDI) and zeta potential by dynamic light scattering. FTIR and XRD studies were performed to examine drug polymer interaction. The ANN-optimized nanoformulation was investigated for in-vitro release, cellular, tumor and tissue uptake. Since a nanoformulation, on accounts of the smaller size and higher surface to volume ratio alters its biological behavior and encapsulated therapeutic agent, the newly developed nanoformulation-based drug delivery system was also assessed for its toxicity and safety. The optimized DOX-GCPQ nanoformulation was anionic spherical micelles with hydrodynamic particle size of 97.8 ± 1.5 nm, PDI <0.3, zeta potential 28 ± 2mV and encapsulation efficiency of 81 ± 1.5%. Nanoformulation demonstrated a sustained release pattern over 48 h, assuming Weibull model. Fluorescence microscopy revealed higher uptake of DOX-GCPQ in Human Rhabdomyosarcoma (RD) cells as compared to free DOX. In-vitro cytotoxicity assay indicated a significant cytotoxicity of DOX-GCPQ against RD cells as compared to DOX and blank GCPQ (P < 0.05). DOX-GCPQ exhibited low IC50 (1.7 ± 0.404 µmol) when compared to that of DOX (3.0 ± 0.968 µmol). In skin tumor xenografts, optical imaging revealed significantly lower DOX II GCPQ in heart and liver (P < 0.05) and accumulated mainly in tumor (P < 0.05) as compared to other tissues. For toxicological studies, the optimized and characterized DOX-GCPQ was for size, charge, population dispersity, stability, encapsulation efficiency and in-vitro biocompatibility against rat’s whole blood. Apoptosis was studied in Human Rhabdomyosarcoma (RD) cells. DNA damage was investigated in rat bone marrow using in-vivo micronucleus assay. Hemo-, nephro-, hepato- and cardio- toxicities were studied after three dose cycles (6mg/kg each) in DOX vs DOX GCPQ treated mice keeping untreated group as healthy control. DOX-GCPQ demonstrated higher hemocompatibility, significant apoptotic potential as compared to DOX alone. Rat bone marrow examination depicted fewer micronucleus formation after 24 h of single oral dose of DOX-GCPQ (6mg/kg). Significant (P<0.001) decrease in whole body weight and weights of heart, liver and kidney was observed in DOX vs DOX-GCPQ. DOX induced nephron-, hepato- and cardio-toxicities were indicated by significantly (p<0.0001) high serum biomarkers (urea, uric acid, creatinine, ALT, AST, ALP, total bilirubin, CK, CK-MB, LDH); and low antioxidant enzyme (SOD, CAT, GSH, MDH) levels when compared with DOX-GCPQ. Mild vascular congestion in liver and kidney tissues was observed with DOX-GCPQ, while DOX induced vasculature changes coupled with marked vascular congestion, and distorted glomerulus. DOX raised cardiac risk ratio and atherogenic coefficient that modifies lipid metabolism. However, a mild vascular congestion in liver, kidney and heart tissues, nevertheless comparatively lesser than DOX was found with DOX-GCPQ. DOX significantly (p<0.005) reduced serum lipid markers and raised serum electrolytes (p<0.005) in contrast to control. DOX-GCPQ nanoformulation sustained (p>0.005) above parameters. The features of nanoformulation, i.e., small particle size, sustained drug release, enhanced cellular uptake, potential to target tumor passively coupled with the possibility of monitoring of tumor localization by optical imaging may make DOX-GCPQ an efficient nanotheranostic system which may also work as future safe drug carrier system with reduced DOX-induced organ toxicity.
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