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سید محمد احمد کاظمی

سید محمد احمد کاظمی
افسوس ہے پچھلے دنوں محمد احمد صاحب کاظمی کاانتقال ہوگیا۔مرحوم مولانا سید طفیل احمد صاحب منگلوری کے فرزند ارجمند اورایک نامور خاندان کے چشم و چراغ تھے۔الہٰ آباد ہائی کورٹ کے بڑے کامیاب ایڈوکیٹ اور ممبر پارلیمنٹ تھے۔ پارلیمنٹ میں وقف ایکٹ کے مصنف وہی تھے۔نیشنلزم گویاان کی گھٹی میں پڑا تھا۔کانگریس کے علاوہ جمعیۃ علمائے ہند اورمجلس احرار کے بھی سرگرم کارکن تھے۔ اخلاقی اعتبار سے بڑے درویش صفت اور خداترس انسان تھے۔گذشتہ سال جب کہ حج کرکے آئے تھے اس وقت سے ان کی دین داری میں عظیم انقلاب پیداہوگیا تھا۔آنحضرتﷺ کے ساتھ عشق کا یہ عالم تھا کہ نام نامی زبان پرآیا اورچشم پُر نم ہوگئی۔اسی جذبہ سے انگریزی زبان میں ایک ضخیم سیرت نبوی مرتب کررہے تھے جو افسوس ہے کہ نامکمل رہ گئی۔اﷲ تعالیٰ مغفرت وبخشش کی نعمتوں اورراحتوں سے نوازے۔ [دسمبر۱۹۵۹ء]

 

نقض امن میں ‘‘ف’’ سے شروع ہونے والے سات عوامل کا کردار

According to the certain teachings of al-Qur’ān mentioned at four different places (4: 1, 6: 98, 7: 189 and 39: 6), all humans have their origin in a single cell or soul. One of the objectives behind these proclamations is perhaps to ensure that the unity of humanity at large and of the Muslims in particular, is never to be compromised and that the differences existing among them are to be resolved through a process of mutual understanding on the basis of the notions derived from the al-Qur’ān (2: 213) and Sunnah. AlQur’ān and Sunnah acknowledge the human diversity, rather, describe it as a functional aspect of existence, but not as structural. Referring to the Quranic verse 5: 48, Allah would have made humanity a single people, but, His plan is to test them in whatever He has given to them, so they should emulate for virtues. The present article is an attempt to shortly describe the role of the seven crucial factors in disruption of peace, all starting with the Arabic alphabet fā, i. E., Fitnah, the false Fatāwā, Fujūr, Fakhr, Furqah, Fisq and Fasād, with the purpose of developing an overall religious harmony for strengthening the inner and the outer peace. These seven factors play significant role in disturbing the stability of society. The Islamic injunctions also stress that these factors should be avoided in order to live a righteous and peaceful life.

Mass Spectrometric Profiling and Bioevaluation of Phenolic Constituents of Coronopus Didymus

Coronopus didymus is a medicinal plant used traditionally as antipyretic, expectorant, blood purifier and for alleviating symptoms of pain, inflammations, malaria, wounds and cancer. The present study was designed with the objectives of revelation of diagnostic compounds responsible for biological activity of this plant. This work is divided into two main parts, part I includes extraction, preliminary phytochemical analysis, isolation, purification, and identification of phenolic constituents by using mass spectrometric technique. Part II comprises bioevaluation of plant for cytotoxic, antioxidant and antimicrobial activities. Total phenolic content of various solvent extracts was determined using the Folin-Ciocalteu assay. Polar and non-polar constituents of C. didymus were identified by ultra performance liquid chromatography-electrospray ionization-mass spectrometric (UPLC-ESI-MS) and gas-chromatography-mass spectrometric analysis (GC-MS), respectively. Major constituents of C. didymus were isolated by using Sephadex LH-20 column chromatography and preparative mass directed HPLC method. The phenolic content was found to be the highest in the ethanolic extract (CDA Et, 47.8 mM GAE). Eighteen phytochemicals were tentatively identified from ethanolic extract by UPLC-ESI-MS analysis. The predominant compounds of aerial parts were flavonoids while roots contained glucosinolate as the major component. Sixty-three volatile phytochemicals were identified from aerial parts and roots of C. didymus by GC-MS analyses. Mass spectrometric profiling of the C. didymus extracts, confirmed that this plant contained a plenty of compounds. The structures of isolated compounds were elucidated by UV-Vis. spectroscopy (with shift reagents), LC-ESI-MS and NMR spectral data as 5,7,4''trihydroxy-3''-methoxyflavone-4''-O-β-D-glucoside (1''), 5,7,4''-trihydroxy-3''methoxyflavone-4''-O-(6''''-acetyl)b -D-glucoside (2'') and 5,7,4''-trihydroxy-3''-methoxy flavone (3''). Compound 1'' was identified for the first time from the genus Coronopus. Extracts, fractions and isolated compounds were subjected to various bioassays in a dose dependent manner to understand their anticancer, antioxidant, antifungal and antibacterial susceptibility. Isolated compounds 1''-3'' showed promising activity against HeLa cells with IC50 values of 43.50, 0.63 and 3.67 µM, respectively. Significant result was also obtained with compound 3'' against LN18 cells with IC50 value of 46.63 µM. In antioxidant activity, compound 3'' was far more effective in scavenging free radicals in the DPPH and ABTS assays with IC50 of 43.8 and 0.08 µg/mL, than the standard trolox, with IC50 values of 97.5 and 21.1 µg/mL, respectively. Compound 3'' depicted largest zone of inhibition (15 mm) against X. campestris, which was even higher than the chemical bactericides viz., bismerthiazole and kasugamycin, with inhibition zone of 11 mm and 14 mm, respectively. Mass spectrometric profiling and the cytotoxic, antioxidant and antimicrobial activity of the phenolic constituents 1''-3'' provide a scientific basis for the ethnopharmacological use of C. didymus for various applications.
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