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خواجہ عبدالمجید

خواجہ عبدالمجید
افسوس ہے پچھلے دنوں ملک کے مشہور نیشنلسٹ خواجہ عبدالمجید صاحب بیرسٹر ایٹ لا کا انتقال ہوگیا۔مرحوم صفِ اوّل کے نیشنلسٹ مسلمان اور قومی کارکن تھے۔ علی گڑھ کے تعلیم یافتہ اوراُس کی تہذیبی روایات کے پورے حامل ہی نہیں بلکہ ترجمان تھے۔برسوں سے مسلم یونیورسٹی کورٹ اوراُس کی اکزیکٹیو کونسل کے بہت بااثر ممبر تھے اوریونیورسٹی کے معاملات میں بڑے جوش وخروش اور سرگرمی سے حصّہ لیتے تھے۔بہت پرانے کانگریسی کارکن تھے اوراس لیے کانگریس کے عمائد اورپنڈت جواہرلال نہرو اورسابق صدر جمہوریہ دونوں خواجہ صاحب کابڑاادب اورلحاظ کرتے تھے مگر حق بات کہنے اورکرنے میں اُنہیں کبھی تامل نہیں ہوتاتھا۔بڑے مخلص،انتہائی وضعدار،شرافت ومروت اوراخلاق ومکارم کا نمونہ تھے، اُن کا دروازہ ہرضرورت مند کے لیے ہروقت کھلارہتا تھا۔ اب ادھربرسوں سے معذور تھے، مگرقومی کاموں میں اس کے باوجود تندہی سے منہمک رہتے تھے۔اب ایسے بزرگ کہاں ملیں گے۔اﷲ تعالیٰ انہیں مغفرت ورحمت کی نعمتوں سے سرفراز فرمائے۔ [جنوری۱۹۶۳ء]

 

پاکستان میں غیر مسلموں کے جان و مال کا تحفظ، قرآن وسنت کی روشنی میں خصوصی مطالعہ

This fact is quite obvious from Quran o Sunnah that Islam is a religion of peace and provides guarantee of protection of life, property and self respect to the all members of society without any discrimination of colour, race and religion. It is the duty of an Islamic State to provide protection to the basic rights of all minorities. Holy Prophetﷺ said: "Beware! Whoever is cruel and harsh to a non-muslims minority, curtailing their rights, overburdening them or stealing from them, I will complain (to God) about that person on the day of judgement." Islam seeks to establish such a society where all citizens of the state enjoy equal rights and religion doesn't become the basis from any discrimination. Islamic law holds both muslims and non-muslims equal and no superiority or privilege is given to the muslims on any ground.

Synthesis, Characterization and Biological Evaluation of Some Metal Complexes With Ligands Containing Cyclic Moieties

The research work describes the synthesis and characterization of compounds containing cyclic and heterocyclic moieties, Phthalimide and phenyl amide compounds aiming at search of new candidates to battle with microorganisms. Thanks to metals for being the charm of medicinal and pharmaceutical chemistry since many decades. To widen this search, 15 potential ligands were synthesized. Compounds containing phthalimide moieties (HL1-HL6) were synthesized by the reaction of various anilines with phthalic anhydride. The compounds were isolated in pure form and checked by TLC and had sharp melting points. The single crystal structures of the compounds were also reported and discussed. Then the compounds were treated with metal salts e.g, Zn (II), Fe (III), Cu (II), Sb (III) and as a result thirty four new metal complexes were synthesized. Further, phenylamide derivatives (HL7-HL11) were synthesized by reacting anilines with acetic anhydride. HL12-HL15 were synthesized by reacting substituted anilines with maleic anhydride and succinic anhydride. Forty new complexes of these amides with metals e,g Zn (II), Fe (III), Cu (II) and Sb (III) have been synthesized. All of the synthesized complexes were heat, air and moisture stable, but during the synthesis moisture and air were avoided to prevent the oxidation of the compounds using standard Schlenk line and glove box techniques. The stability profile augments the link between organometallics and drug design and discovery. The purity of all synthesized compounds was conventionally monitored with the help of TLC in different solvents. All synthesized compounds and their complexes with transition metals were characterized by elemental analysis, FTIR, GC-MS, 1H and 13 C-NMR spectroscopy. The structures were finally confirmed with the help of single crystal structures. All synthesized compounds and their metal complexes were evaluated for their carbonic anhydrase inhibition, intestinal alkaline phosphatase inhibition, antileshminial, anti oxidant, cytotoxic and antibacterial activities. The results of these bioassays are also reported and discussed in detail. The phenylamide ligands showed good carbonic anhydrase inhibition, as compared to phthalimides ligands. Further, the activity was enhanced by 40-60% in case of antimony complexes but the zinc complexes have shown slightly less carbonic anhydrase inhibition. Similarly, the complexes of antimony with amide ligands have shown excellent IAP inhibitory activities, while the zinc complexes have shown a maximum potential against IAP inhibition. Although most of the compounds are found to be good antileshminial inhibitors, the results have proved that the metal complexes of Zn, Cu and especially Sb have increased activities as compared to parent free ligands. Additionally, the said complexes also showed enhanced cytotoxic activities against BHK-21 and H-157 cell lines. The antibacterial activity against Gram –ve and Gram +ve bacteria were outstanding in case of metal complexes with the phthalimide ligand HL2. Results of antibacterial screening of compounds as percent inhibition against bacteria are reported. Overall, these newly synthesized metal complexes have provided important candidates for drug discovery. These candidates may be improved to be used as drugs, having enhanced pharmacological action.
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