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3۔اندھا بوڑھا

اندھا بوڑھا

نعمان نذیر

صبح ہوتے ہی  معمول سے کچھ دیر پہلے ہی اس کی آ نکھ کھل گئی ۔ یوں تو وہ آ غاز سے ہی اپنے کام میں مہارت کے ساتھ ساتھ وقت کی پابندی کا بھی قائل تھا۔ شاید ہی ان دس سالوں میں کھبی اس کو افسران بالا کی طرف سے اس بات کا اعتراض کیا گیا ہو کہ وہ وقت پہ دفتر نہیں پہنچا ۔ ان دس سالوں میں اس کے افسر جو متعدد تبدیل ہو چکے تھے۔ کوئی بھی اس کے کام پہ معترض نہ تھا۔۔۔۔۔۔۔

آج اس کی زندگی کا ایک اہم دن تھا۔ اس موقع پہ اس کی بیوی بھی اس کی خوشی میں برابر شریک تھی۔ اسی کی خدمت اور حوصلے سے تو وہ آ ج اس مقام تک پہنچا تھا۔۔۔۔۔۔۔۔

اس خبر کا انتظار اسے گزشتہ دو سال سے تھا ۔ وہ مسلسل اپنی محنت کا پھل پانے کے لئے آ ج تیار تھا ۔ یہ دن تھا اس کی محکمانہ ترقی کا۔۔۔۔۔

اس خبر کی اطلاع تو اسے نیم کلرک نے ایک مہینہ قبل ہی دے تھی۔ جب اس کی ترقی کا پروانہ مرکزی دفتر میں دستخط ہونے کا منتظر تھا۔ ۔۔۔

اس موقعہ کو یاد گار جانتے ہوئے اس نے نیا قیمتی لباس بھی تیار کروایا تھا ۔ گزشتہ اتوار کو وہ اپنی اہلیہ کے ہمراہ شہر کے سب سے بڑے شاپنگ مال میں کپڑے اور جوتے خریدنے گیا ۔ اس کی بیوی نے اپنے خرچ میں سے جمع کی گئی رقم سے مہنگے جوتے خرید کر تحفہ دیا۔ جو اس کی اس کامیابی کو اپنی کامیابی سمجھتی تھی ۔۔۔۔۔

آ خر کار 15 ستمبر کے دن کا سورج طلوع ہوگیا ۔ وہ معمول...

سیرت رسول عربی ﷺ(از نور بخش توکلی)کے منہج و اسلوب کا تجزیاتی مطالعہ

The topic of ‘Sacred role (Seerat)’ with the affinity of the Rasool (saw) having significance, status and vast acceptance is undoubtedly beyond expression. If we make analysis of a religious literature, we find most of its part consisting on such topics that are directly affiliated with the silent features of the personality of the Rasool (saw). In storehouse of knowledge and architecture of the world ‘Art of Sacred role’ has attained its prominent supremacy. The beginning of this art was based on the details of Ghazwat in Islam but with the passage of time, it was enlarged in such a way that a great piece of literary work on ‘Sacred role’ has been pin pointed in sub-continent. Many literate of persona put forth their pens on this topic out of whom Noor Bakhsh Tawakli is also the most famous name who wrote a with title of “Seerat Rasool-e-Arabi” on the personality of Rasool. The expression of the affection and following of the Rasool (saw) by Noor Bakhsh Tawakli is expressed by the leaves of this book. He is best known for his popular for this book which has its own status in this field. He wrote the book in the era during which the western civilization had strangled the youth of that time. Materialism was in its climax. A great piece of strife was being made to disintegrate the true bond of affection and following of the Rasool (saw) but the profundity of learning, recognition of knowledge, strict eye on the present condition of that time and the salient factors of love of the Rasool (saw) were quite dominant in this book. The leaves of which were enriched with the florescence of love and affection of Rasool(saw).  

Synthesis, Structure Elucidation & Biological Evaluation of Molecules from Piperine Alkaloid

Piper nigrum is a medicinal plant and commonly used as household spice, having piperine alkaloid as major and active ingredient. Piperine is an antibacterial compound and its multiple uses have already been established in literature, therefore it is widely used in folk. There are many other potent antibiotics available in the market that contain substituited-1,3,4-oxadiazole heterocyclic ring structures. The high resistivity of microorganisms towards the prevailing drugs motivated us to synthesize new bioactive molecules by combining the piperine backbone to biological active oxadiazole system. It was assumed that 2,5 – disubstituited-1,3,4- oxadiazole heterocyclic ring may act as potent biological active molecules that boost the pharmacological activities to the new limits. The presented research work comprises the synthesis of some novel multifunctional derivatives followed by structural characterization & biological evaluation. Piperine alkaloid is extracted in lab using soxhlet apparatus, purified, further derivatized and characterized. Piperine, by basic hydrolysis, is converted to piperic acid, which on esterification changed into ethyl piperate and upon reaction with hydrazine lead to piperine hydrazide molecule, which acts as backbone for further derivatization. Piperine hydrazide in three different routes changed to 1-oxadaizole moiety by reacting with CS2 in aprotic solvents, 2- Imine functionality bearing molecules by reacting with various aldehydes, 3-sulphonamide functionalities by reacting with various aryl sulphonyl chlorides. Oxadiazoles further converted to oxatriazole by reacting with hydrazine. Overall we have synthesized 83 derivatives of piperine, with oxadiazole, oxatriazole, amide, imine and sulphonamide functionalities. The compounds presented in this work were synthesized according to available protocols in the literature and has been mentioned in seven schemes in detail (at the end of Chapter 1: Introduction). These synthesized compounds were purified through chromatographic techniques including column chromatography and preparative chromatography. Structures of all these were elucidated through IR, EIMS, 1H and 13C NMR spectroscopic techniques. As literature showed that various molecules containing these type of functionalities are biologically active and used for the treatment of various diseases. This encouraged us to evaluate piperine derivatives to search for more biological active or potent molecules. We have evaluated antibacterial, antifungal, hemolytic and thrombolytic xxvi activities. Some selected molecules from these series were also evaluated for analgesic and anti-inflammatory potential. The antibacterial activity was studied against both gram positive (Bacillus subtilus) and gram negative (Escherichia coli) bacterial strains and also evaluated as antifungal activity against Aspergilus niger strain. We have also investigated their toxicity through hemolytic and thrombolytic activities using blood as a substrate. Analgesic and anti-inflammatory activities for selected compounds were performed using swiss albino mice, which showed very encouraging results. Out of seven prepared series, the series (6a-s) in wihich piperidine ring is replaced with oxadiazole moiety shows most significant results. Two of the derivatives (6b & 6h) from this series (6a-s) found more potent antibacterial activity when compared with diclophenac sodium standard. From same series 6l & 6p showed improved hemolytic activity while 6e & 6f exhibited better thrombolytic activity as compared to piperine.7a-p series have aryl derivatives of oxadiazole-amide functionalities and in this series 7b showed the maximum antimicrobial activity while 7l and 7e of this series exhibited better hemolytic and thrombolytic activities respectively. A minor change in carbon chain for the series 8a-p as compared to 7a-p display overall decrease in activities, however prominent antibacterial and antifungal activities were shown by 8a and 8d. Schiff base containing derivative, 10l showed prominent hemolytic activity among the other members of this series. Sulphonamide bearing derivatives 11a-e showed moderate thrombolytic and hemolytic activity but 11e exhibited maximum antibacterial & antifungal activities. Oxatraizole containing derivative 12b and 12f found to have better thrombolytic activity as well as good antimicrobial agents.Selective derivatives were analyzed against analgesic and anti-inflammatory activities. Addition to Schiff Base moiety to piperine (10h) showed maximum analgesic activity (tail + hot plate method) even higher than Diclofenac sodium standard, while simple oxadiazole (5) and alkyl substituted oxadiazole (6o) showed maximum anti-inflammatory activities.Overall it is concluded that introduction of new functionality to piperine alkaloid made the molecules potent than the parent in most of the cases.
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