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وصلؔ بلگرامی

وصلؔ بلگرامی
اس ماہ یوپی اور بہار کے دو ممتاز شاعروں اور ادیبوں کی وفات کی اطلاع ملی، ان صفحات میں ان مرحوموں کا ذکر اس لئے ہوتا ہے کہ ہماری آئندہ نسلوں کو اپنے پچھلوں کے نام نیک کی خبر رہے، اسلامی تاریخ کا ایک بڑا اہم کارنامہ وفیات یعنی ہزاروں لاکھوں بزرگوں، فاضلوں، ادیبوں اور ممتاز لوگوں کی وفات کی تاریخ کا تعین ہے، تاریخ کی اس صنف پر بہت سی کتابیں مدون ہوئیں، کیا عجب ہے کہ شذرات کا یہ حصہ ایک دن اس عہد کے وفیات کے اوراق بن جائیں۔
وصل بلگرامی مرحوم و مغفور کے جاننے والوں اور ملنے والوں کو یہ سن کر بڑا قلق ہوگا، کہ ۲۸؍ رمضان المبارک ۱۳۶۱؁ھ کو رات کے وقت وہ ہمیشہ کے لئے ان سے جدا ہوگئے، مرحوم بڑے ملنسار، متواضع، پُرمحبت، دوستوں کے فداکار اور وقت پر ہر ایک کے کام آنے والے تھے، وہ گو ہمیشہ سے دیندار اور پابند وضع لوگوں میں تھے، جوانی میں حضرت مولانا رشید احمد صاحب محدث گنگوہی سے ملتے تھے اور اب ادھر دس بارہ برس سے حضرت مولانا اشرف علی تھانوی (متعنا اﷲ تعالیٰ بفیوضہ وبرکاتہ) سے ان کی ارادت کا تعلق تھا اور اب وہ زیادہ تر حضرت مولانا کی خدمت میں تھانہ بھون ہی میں خانقاہ امدادیہ کے ایک حجرہ میں مقیم رہتے تھے، وہیں اسی حجرہ میں چند روز کے بخار میں اچانک وفات پائی، شیخ نے اپنے مرید کی نماز جنازہ پڑھائی اور وہیں کے قبرستان میں تدفین ہوئی۔ خاکسار سے مرحوم کے تعلقات بہت پرانے تھے، ۱۹۰۶؁ء میں میری تعلیم ختم ہوئی اور وہ اس عمر میں تھے کہ عالمگیر کے نام سے ایک رسالہ نکال رہے تھے، ان سے بلگرام ہی کی مردم خیز زمین پر اسی زمانہ میں ملاقات ہوئی تھی، اس وقت وہ جوان شاعر اور ادیب تھے،...

Influence of Advertising on Consumer Buying Behavior for Conspicuous Products

This research articulates the influence of advertising on consumer buying behavior for conspicuous products. Aim of conducting this study was to analyze the impact of advertising liking and advertising attitude on consumer buying behavior, mainly to investigate that either the advertisements are effective to convince the people to spend money on conspicuous products or to influence their buying behavior. Findings of this research will be beneficial to overcome the problem of advertisers focusing more on advertisements contents and effectiveness of advertisements. In order to investigate this, data was collected by showing different advertisements to the responders and it was asked for to fill up the questionnaire. According to our findings, there is a significant and positive influence of advertising on consumer buying behavior for conspicuous products. Which means that it contributes much in influencing consumer buying behavior through both national product advertisements and international products advertisements.

Therapeutic Effects and Safety Profile of Atorvastatin on Psoriasis Severity Associated With Cardiovascular Risk

Several studies occurs on anti-hyperlipidemic drug Atorvastatin and its pleotropic effects. However its relationship with Psoriasis and association of cardiovascular risk in comparison of standard therapy with large sample size has not been studied in Pakistan. Topical Betamethasone is the first line treatment in the management of all grades of Psoriasis as a monotherapy and in combination therapy. Beyond lipid lowering mechanism Atorvastatin have pleiotropic effect through direct inhibition of small GTPase protein (Rho, Rac, Ras and Rab). These protein control multiple signaling pathways involve in pathogenesis of immuno-inflammatory diseases like Psoriasis. Statin modulates the altered expression of these prenylated proteins. Psoriasis is important disease for researcher because it serves as a model disease to study the basic principle of immune mediated inflammation that is the reason by which in clinical trial it acts as a model for new research studies. Psoriasis is associated with other co-morbidities, the most important is cardiovascular risk. OBJECTIVE: Present study demonstrates that Atorvastatin has dual action on severity of psoriasis and cardiovascular risk (CVR). METHODS: This was an interventional study conducted in Pharmacology Department of BMSI, JPMC with the collaboration of Pathology Department, BMSI, JPMC and Dermatology Department of JPMC. This research project consist of two phases one was the preclinical conducted on ninety adult Wistar Albino rats divided into three groups, Group A (Control), Group B (Doxorubicin induced toxicity) and Group C (Atorvastatin pretreated). Other was the clinical study on mild to moderate xxvi plaque type psoriatic patients. 225 psoriatic patients enrolled in this study those who fulfilled the inclusion and exclusion criteria. The inclusion criteria were, both male and female age ranging from 25-65 years, PASI score <12, hs C-RP ≥ 3. These patients further divided into three groups. Group A prescribed tab. Atorvastatin 80mg for first three month followed by 40mg for next three months. Group B prescribed Placebo and topical Betamethasone valerate 0.1% twice daily for 3 months and once a day for the next 3 months (three weeks apply than one week interval and for sensitive area 50% betamethasone in soft paraffin). Group C prescribed tab. Atorvastatin 40mg for the first three months followed by 20 mg for next three months plus topical Betamethasone valerate 0.1% once daily for 6 months (three weeks apply than one week interval and for sensitive area 50% betamethasone in soft paraffin). The efficacy and safety profile of drug assists preclinically by biopsy of rats myocardium and clinically by PASI, hsCRP, DLQI, Lipid Profile, LFTs and CPK.
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