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حکیم محمد اسمٰعیل

حکیم محمداسماعیل
حکیم محمداسماعیل صاحب کے انتقال کی خبرسے بڑاصدمہ ہوا،مرحوم نے بڑی تکالیف اٹھائیں،اﷲ تعالیٰ مغفرت فرمائے۔ [اکتوبر ۱۹۶۲ء]

 

Probing Interpersonal Dynamics: A Thematic Analysis of Kamila Shamsie's 'Best of Friends'

This research scrutinizes Kamila Shamsie's novel, “Best of Friends”, authored in September 2022, employing a qualitative methodology and data analysis approach to discern major thematic elements. The study identifies five principal themes, encompassing ambivalence within friendships, societal norms and the suppression of desires, political and ethical decision-making, the construct of womanhood, and the motif of unhomeliness. This study applies Braun and Clarke's established six-phase thematic analysis framework (2006) to achieve its research objectives. The research expounds upon the interplay of these identified themes and their reverberations within the lives of the individuals central to the narrative, illuminating the intricacies that underpin the friendship between the main characters. Significantly, the analysis establishes a poignant connection between the novel's title, 'Best of Friends,' and the central theme of ambivalent friendships explored therein. This investigation not only advances comprehension of the thematic nuances within the novel but also underscores the depth and complexity of the issues it addresses. It serves as a foundational exploration, providing a springboard for future research on this recently published work and presenting a diverse array of narrative facets for scholarly inquiry.

Is There an Association Between Placental Inflammatory Lesions and Vaginal Microbiota in Preterm Labour? a Case Control Study

Background: Preterm birth continues to be a significant contributor to neonatal mortality and morbidity despite diverse unique interventional strategies. There is need for better understanding of differences and influences of the now characterized vaginal microbiome on terminal inflammatory effects in the uterine microenvironment in term and preterm labour to improve on current strategies. How the existence of a postulated placenta microbiome also affects this understanding should be considered. Objectives: The aim of this study was to explore the association between the maternal vaginal microbiota and placental inflammatory lesions in preterm labour and to determine the presence of a placenta microbiome. Methods: In this nested study, we enrolled 36 case and control placentas in a 1:1 ratio matched for age and parity from women delivering preterm between 26 to 36 weeks gestation. The profile of bacteria in the vaginal tract and placenta was characterized and compared through 16S rRNA sequencing. All histologic inflammatory lesions were graded and staged as per recommended latest consensus guidelines on reporting placental lesions. Results: Preterm placentas were associated with greater rates of inflammation (43.3%) compared to term placentas (23.3%). Acute histologic chorioamnionitis accounted for the greatest proportion with higher rates in preterm (33.3%) than term placentas (6.67%). Placenta microbial samples had a sequence read success rate of only 5.7% bearing similarity to oral, environmental and vaginal tract bacteria. Conclusion: (1) Acute histologic chorioamnionitis was associated with preterm labour. (2) There is lack of evidence to support the existence of a placenta microbiome.
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