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خلاصہ بحث

خلاصہ بحث

قرآن مجید اللہ تعالیٰ کا کلام ہے جس میں مختلف انداز واسالیب کا ذکر کیا گیا ہے تاکہ انسانی نفوس پر کلام گراں نہ گذرے۔مختلف اسالیبِ قرآنی میں سے ایک اسلوب اسلوب ِاستفہام ہے۔ قرآن مجید میں اللہ تعالیٰ اپنے بندوں سے مختلف سوال فرماتے ہیں جو کہ مختلف نوعیت کے حامل ہوتے ہیں۔ ان سوالات کی آیات کو آیاتِ استفہام کہا جاتا ہے ، جن میں کئی ایک مصلحتیں پوشیدہ ہیں ۔کہیں انسان کو ڈرانے کے لئے سوال ہے تو کہیں باطل کا رد کرنے کے لئے ،کہیں بغرض توبیخ کے ہے تو کہیں تشویق کی غرض سے، الغرض استفہامی اسلوب کو متعدد مقامات پر متعدد مقاصد کیلئے لایا گیا ہے۔فصل ہذا میں استفہام کے لغوی واصطلاحی معنی بیان کرتے ہوئے ادوات استفہام کی وضاحت کی گئ ہے اور قرآن کا استفہامیہ اسلوب بیان کیا گیا ہے آیات استفہام کی تعداد اور جن سورتوں میں یہ وارد ہوئیں ہیں انکی تعداد بیان کی گئی ہے اور تفاسیر کی روشنی میں آیات استفہام کا تحقیقی جائزہ پیش کیا گیا ہے۔قرآن مجید میں کل نو(۹) ادواتِ استفہام کو ذکر کرتے ہوئے قرآن مجید کی چھیانوے (۹۶) سورتوں میں کل آٹھ سو چونسٹھ (۸۶۴) آیات میں استفہامی اندازِ بیان کو استعمال کیا گیا ہے۔

 

PENDIDIKAN IPS BERBASIS KEARIFAN LOKAL DENGAN PENDEKATAN ETNOPEDAGOGY DITINJAU DARI PRESPEKTIF KURIKULUM

The personal social issues experienced by students in daily life are important studies in social studies education. The study of the role of the environment is very important in preserving local wisdom that is beginning to be abandoned by the younger generation, especially the students as a generation of gold who will continue the eastafet stick of development. The importance of a learning approach that is relevant to the situation of students, learning in accordance with the real world reality of students with ecological intelligence (Ekopedagogy) by exploring local wisdom that can be developed through social studies with the selection of contextual material, and meaningful for students to develop skills concern for the community, and place empathy as a form of positive attitudes towards environmental conservation based on local wisdom through the ecopedagogy approach. Keywords: social studies, local wisdom, ethnopedagogy

Screening of Therapeutic Potentials of Rosa Damascena Mill Flower Aqua Distillate As Neuropharmacological, Antimicrobial and in Different Metabolic Disorders

The necessity of novel chemical entities is intensively served by the plant and herbal sources in the improvement and betterment of health care system. Majority of the marketed medicines are either derived or inspired by herbal medicinal products. There are several drugs in allopathic system that are derived from natural sources, mainly from plants. Today there is an extensive list of plants with known therapeutic activity. Natural resources are still considered as an important source for discovery of novel drugs and compounds. Rosa damascena Mill. also known as Damascus rose, Damask rose or Rose of Castile belongs to Rosaceae family is famous all over the world for its pleasant aroma and ornamental beauty. It is widely cultivated all over the world and is considered highly beneficial for human health as it contains high content of organic and inorganic compounds such as vitamins, minerals, bioflavonoids, tannins, carotenoids, phenolic compounds etc. Aqua distillate of Rosa damascena Mill. prepared by hydro-distillation process is a rich source of polyphenols, bio-flavonoids, terpenes, volatile components and contains citronellol, geraniol, quercetin, kaempferol, eugenol, ellagic acid, linalool etc. As majority of the therapeutic and pharmacological uses reported from Rosa damascena Mill. flower are of its aqueous, hydro-alcoholic, ethanolic, methanolic or chloroformic extracts or of its essential oil and very limited pharmacological studies were done on aqua distillate of this plant, therefore, this research is designed to investigate the pharmacological potential of aqua distillate of Rosa damascena Mill. at two different doses i.e. 250mg per kg and 500mg per kg. In neuro-pharmacological studies, results of open field, light and dark box, water maze and passive avoidance tests revealed remarkable anxiolytic and memory boosting effects of aqua distillate of Rosa damascena Mill. administered in two different doses suggesting its beneficial role in different anxiety disorders and memory impairment. HPLC analysis of brain biogenic amines revealed positive effects of aqua distillate of Rosa damascena Mill. on brain dopamine and serotonin levels and showed its ability to prevent depletion of these amines and decrease their conversion into respective metabolites in brain suggesting its promising role in cognitive impairment, in neuro degenerative diseases such as Parkinson’s (PD), in depression and different anxiogenic states including obsessive compulsive disorder and social anxiety disorder. Alzheimer’s animal model and its histopathological findings revealed neuro-protective and anti-Alzheimer potential of aqua distillate of Rosa damascena Mill. which could be a novel addition in antiAlzheimer’s remedies. In in-vivo anti-inflammatory and anti-nociceptive studies, our findings revealed notable anti-inflammatory and anti-nociceptive potential of aqua distillate of Rosa damascena Mill. at both doses. Our findings on metabolic disorder models revealed marked anti-hyperglycemic and antihyperlipidemic activities of aqua distillate of Rosa damascena Mill. in diabetes induced and hyperlipidemic rats respectively, suggesting its positive role in treatment of diabetes and hyperlipidemia. Our findings from metabolic cage method also revealed mild diuretic effects of Rosa damascena Mill. (aqua distillate). Hematological screening of Rosa damascena Mill. (aqua distillate) at both doses revealed hematopoietic potential of Rosa damascena Mill. suggesting its beneficial role in anemia, leukopenia and thrombocytopenia. Biochemical screening of Rosa damascena Mill. (aqua distillate) at both doses showed no fatal and toxic effects on major organs such as liver, kidney and heart suggesting its strong safety profile. Safety profile was also established by LD50/brain shrimp lethality assay in which aqua distillate of Rosa damascena Mill. showed no cytotoxicity suggesting its cyto-protective action. Overall these studies revealed numerous health promoting and therapeutic benefits of aqua distillate of Rosa damascena Mill.
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