Search from the Journals, Articles, and Headings
Advanced Search (Beta)
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...

۴۔ زہر رگوں میں اتارنا پڑتا ہے

زہر رگوں میںاتارنا پڑتا ہے

تپتے سورج کی کرنوں کے نوکیلے پتھر

فگار دن کے برہنہ سر پر برس رہے تھے

ریل کی پٹری کو کاٹتی ہوئی کہنہ سڑک پر

انبوہِ آدم رواں دواں

قریب ہی پُل کے نیچے بیٹھے دھوئیں میں پریشاں حال

اپنے وجود کو تلاشتے چند انسان

موت کی آغوش میں پلتے ہوئے

دشت نما چہروں پر بے خوابی کی جھریاں

بد قسمتی کی دھول میں اٹے ہوئے بال

بوسیدہ پیراہن سے جھانکتا استخواں

آنکھوں میں خمارِ آشفتگی

جس میں ٹھکرائے جانے کا غمِ جاوداں پنہاں

 اس ہجومِ آشفتگاں سے ایک ژولیدہ مو

اپنی رگوں میں زہر اتارنے لگتا ہے

 زندگی بے اختیار چیخنے لگتی ہے

اے دشمنِ جاں یہ کیا۔۔۔؟

آشفتہ نوا گویا ہوا

سن اے زندگی!

’’خدا نے فقط تجھے عطا کر کے

بدلے میں مجھ سے کیا کچھ نہیں چھینا

اُس کے بے اماں جہان میں

رشتے بکتے ہیں

جذبات کا بیوپار ہوتا ہے

محبت بھیک مانگتی، تلوے چاٹتی ہے

جھوٹ مسکراتا ہے

سچ دریوزہ گر ہے

ہر کوئی نفرت کا خریدار ہے

اپنے بیگانے ہیں

یہ سب دیکھنے اور سہنے کے لیے

زہر رگوں میں اتارنا پڑتا ہے‘‘

سیرت النبی ﷺ میں احتسابی عمل کی مثالیں: وفاقی محتسب پاکستان کے فرائض کا اختصاصی مطالعہ

In any society, the administration has the status of a pillar, and its good or bad move directly impacts society. There are institutions to compensate public complaints on government initiatives in many countries of the world that keep check on government administrations. For this purpose "Federal Ombudsman" was established in Pakistan. The main responsibilities of this institution include the execution to enjoin the right and forbid the wrong (Amr bil Ma’rūf wal Nahi ‘An al Munkar), monitoring government employees in administrative matters, hearing the complaints of the public against organizations and preventing them from violating individual rights. In this article, it has been reviewed that how we can seek guidance from the Sīrah of the Prophet (P.B.U.H) is in this matter, to evaluate the present system of "Federal Ombudsman". In addition, the main responsibilities of the "Federal Ombudsman" were discussed in the article. In conclusion recommendations have been made for further improvement.

Development of Targeted Nano Drug Delivery System With Hybrid Materials for Cancer Therapy

Targeted treatment of cancer with new dexterous strategies using biocompatible materials is the hallmark of recent cancer research. In this study three innovative designs of targeted delivery systems with hybrid materials have been developed. Two nanosilica based passive systems are developed using stimuli specific to the tumour micro environment for the delivery of anticancer drugs. In zinc oxide based, active targeted system, the technique of receptor mediation through cancer cell membrane for its internalization has been adopted. The first system is hybrid material with nanosilica based bio-responsive drug delivery system. This system has been developed through a facile surface modification of the silica nanoparticles with biocompatible material. It showed higher entrapment efficiency for anticancer drug doxorubicin with sustained drug release behaviour in vitro. Unique feature of surface charge swapping in response to the lower pH of the tumour microenvironment significantly increased the cellular internalization of the nanocarriers into the tumour tissue as compared to other vital organs. The increased uptake and controlled release of anticancer drug co-jointly contributed to suppress the tumour growth in squamous cell carcinoma (SCC7) bearing nude mice. The second nanosilica based passive targeted system focused to target the hypoxic conditions of tumour. Surface modification of the nanoparticles with biocompatible moieties made the system nontoxic for biomedical applications These PEGylated hypoxia responsive nanocarriers contained higher amount of the anticancer drug and showed sustained release of the drug in hypoxic environment with no premature release in physiological or normoxic conditions. The third system is active targeted carrier possessing core material of zinc oxide functionalized with hyaluronic acid as targeting moiety. The system showed significantly improved cellular uptake, due to receptor mediated endocytosis in T-cells, with controlled release of anticancer drug. Doxorubicin loaded nanocarriers along with methyl aminolevulinate (m-ALA) showed increased cancer cell destruction in RD cells. The biocompatibility, drug loading and its release characteristics, cell uptake, intra cellular drug release, and antitumor efficacy have been evaluated for the above systems. The obtained results exhibited the success of the carriers for their biological response. These newly designed targeted delivery systems fabricated with hybrid materials possess strong potential to open new horizons in of controlled and site specific delivery of anticancer drugs with increased bioavailability and improved therapeutic efficacy
Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.