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ڈاکٹر شرف الدین اصلاحی

ڈاکٹر شرف الدین اصلاحی مرحوم
پروفیسر امیر حسن عابدی اور پروفیسر عبدالقوی دسنوی کا غم کم نہ تھا کہ جناب شرف الدین اصلاحی کے سانحہ ارتحال کی خبر دارالمصنفین اور پوری علمی دنیا کو سوگوار کرگئی۔ اِناﷲ وَ اِنا اِلَیہ رَاجِعُون۔
ڈاکٹر شرف الدین اصلاحی اعظم گڑھ کی مردم خیز سرزمین سے اٹھے، ان کا مولد موضع سنجرپور ہے، مدرسۃ الاصلاح میں تعلیم حاصل کی، مدرسۃ الاصلاح کو اپنے جن فرزندوں پر ناز ہے اور یہ تعداد میں کم نہیں، ان میں ایک یقینا شرف الدین اصلاحی مرحوم بھی تھے، الاصلاح کی تاریخ پر گہری نظر رکھنے والوں نے اس کے مختلف ادوار تقسیم کیے ہیں، اس میں عہد زریں کی نمائندگی کرنے والوں میں بھی اصلاحی مرحوم کا نام شامل ہے یہ بھی کہا جاتا ہے کہ اصلاحیوں میں ان کی ذہانت سب سے نمایاں تھی۔
سنجرپور اور اعظم گڑھ کے اس لائق فرزند کو گروش روزگار نے پاکستان پہنچا دیا، کراچی میں رہ کر اصلاحی مرحوم کی ذہانت کے ساتھ ان کی مشکل پسند طبیعت کا بھی ظہور اس طرح ہوا کہ انہوں نے لسانیات کے موضوع پر تحقیق کے لیے سندھی زبان کا انتخاب کیا، سندھی زبان سیکھی اور ذراسی مدت میں اردو سندھی کے روابط کے رموز و اسرار فاش کرنے کے لائق ہوگئے، پی ایچ ڈی کے لیے ڈاکٹر رضی الدین صدیقی اور ڈاکٹر غلام مصطفی خاں کی خواہش و فرمائش، اصلاحی صاحب کے لیے سخت آزمائش تھی، بقول ان کے ’’لسانیات میرا خاص مضمون نہ تھا اور سندھی سے میں ناآشنائے محض تھا، اس حالت میں اردو سندھی کے لسانی روابط پر تحقیقی کام کا بیڑا اٹھانا بڑی جسارت کی بات تھی‘‘ اصل بات یہ ہے کہ وہ چیلنجوں پر یقین کرنے والے تھے اور اپنی ہمت و محنت سے وہ بار عظیم کو اٹھانے میں کامیاب بھی ہوتے تھے، ہم...

حضور انورﷺ کی رحمت کی امتیازی خصوصیات

The many aspects of the Holy Prophet’s (PBUH) personality has been defined by Allah himself in Quran many times, keeping in view the all angles of the Holy Prophet (PBUH) Character blessings for all worlds and times. The Rehmatul-il-Almeen is infinite. The Holy Prophet (PBUH) has proved such a huge chain by his character. The blessing of the Holy Prophet (PBUH) is such a supreme that, it could not be defined in such an article, but here it has been tried to throw light on some features of Holy Prophet (PBUH) blessing. As Quran says that the secret of man on the path of the Holy Prophet (PBUH). Today same way, man regardless of color, race and religious should know that the wounds of humanity could be headed by following the route of the Holy Prophet (PBUH) Sunnah. All the other ways will lead to cul-de-sac.

Synthesis and Characterization of Some Novel N-Vinyl Pyrrolidone Based Copolymers for Controlled Drug Delivery

Six series of N-vinyl pyrrolidone based copolymers were synthesized by free radical solution polymerization of N-vinyl pyrrolidone and n-alkyl methacrylate monomers. The n-butyl methacrylate and n-hexyl methacrylate were selected as the hydrophobic counterpart. In the first part of the study properties of uncrosslinked poly(N-vinyl pyrrolidone-co-n-alkyl methacrylate) copolymers were modified by varying the weight % ratio of the two monomers. Elemental analyses, FTIR, 1H and 13C NMR spectroscopic analyses techniques were used for structure elucidation of the copolymers. Thermal stabilities and glass transition temperatures of the copolymers were directly related to the amount of n-alkyl methacrylate as well as the alkyl chain length of methacrylate comonomer. The water uptake characteristics of the copolymers were related to the amount of hydrophilic NVP incorporated into these copolymers. The hydrophobic drug dexamethasone was loaded into the copolymers with optimum water uptake and prolonged aqueous stability. The drug release studies were carried out at physiological temperature 37 °C and pH 7.4 for 35 days. Controlled drug release was observed from the selected copolymer films during the study time period. The cumulative drug release was found to be mainly controlled by the amount of hydrophilic monomer and molecular weight of the copolymers. In the second part of present study crosslinked poly(N-vinyl pyrrolidone-co-n-alkyl methacrylate) copolymers were synthesized at fixed weight % ratio of N-vinyl pyrrolidone and n-alkyl methacrylate monomers (i.e NVP : nAMA = 90:10) using various concentrations of polyfunctional monomers employed as crosslinking agents. The effect of crosslinker concentration and functionality on gel content, thermal stability, water uptake, internal morphology and drug release was investigated. Gel contents and thermal stability of the crosslinked copolymers increased with increasing crosslinker concentration as well as its functionality. The water uptake at 37 °C decreased with increasing crosslinker concentration and functionality however the increase in alkyl chain length of alkyl methacrylate resulted in increased water uptake. The crosslinked copolymers with optimized crosslinker concentrations exhibited controlled drug release patterns at 37 °C and pH 7.4. Higher amounts of cumulative drug release were observed for copolymers crosslinked with trifunctional crosslinkers leading to complete drug release in 20-22 days while the copolymers crosslinked with difunctional crosslinker exhibited controlled drug release upto 35 days. The kinetics and mechanism of the drug release was also analyzed.
Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

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