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پیار کے دیپ جلاتی ہوئی پاگل لڑکی

پیار کے دیپ جلاتی ہوئی پاگل لڑکی
کوچۂ عشق میں جاتی ہوئی پاگل لڑکی

جس کو اَن دیکھے جزیروں کی تمنا ہے بہت
باتیں اس ڈھب کی بناتی ہوئی پاگل لڑکی

وہ فقط مجھ کو سنانے کی لگن رکھتی ہے
گیت جھرنوں کے سے گاتی ہوئی پاگل لڑکی

آس کی ڈور سے جینے کا ہنر جانتی ہے
کھلکھلاتی سی، ہنساتی ہوئی پاگل لڑکی

ہے وہ تتلی سی ، گھٹا سی کہ فضاؔ کے جیسے
موسموں کو وہ لبھاتی ہوئی پاگل لڑکی

Human Papilloma Virus Related Head and Neck Squamous Cell Carcinoma-an updated review

Human papilloma virus (HPV) related head and neck squamous cell cancer (HNSCC) has varying etiology, genetic as well as environmental factors involved and differential clinicicopathological features. HNSCC came in the limelight recently due to increased incidence rate and insufficient diagnostic methods. This review will comprehensively focus on the characteristics of HPV associated HNSCC.  It will provide an updated review of our understanding of HPV role in Oral squamous cell carcinoma (OSCC) known to date. Curruntly, three vaccines are available (Gardasil, Gardasil 9 and Cervarix). These vaccines prevent infections with HPV types 16 and 18 HPV-16 is most common type associated with HNSCC. HPV related HNSCC has better prognosis, does not mutate  but inactivatestumor suppressor genes and therefore has comparatively better treatment options. However, there is still a need to improve our methods of sampling, HPV molecular assay and type of specimen to be used.

Antibacterial Activity of Tetracycline Based Gold Nanoparticles

Recent interest in nanomedicine is justified, as synthetic antioxidants and antibiotics suffer from several drawbacks. These nanomedicines have been shown to possess health promoting properties, and they exert no selective physiological pressure on the pathogens that can result in development of drug resistance. Tetracycline stabilized gold nanoparticles (Tet-Au(0) NPs) were combined by using chloroauric acid (HAuCl4) with the assistance of tetracyclineby using a facile method. The Tet-Au(0) NPs were observed by UV-Vis absorption spectroscopy, which inveterate the formation of gold nanoparticles by stimulating the characteristic surface Plasmon absorption maxima at 515 nm. While the confirmation of bonding of specific tetracycline with gold metal exhibited, the formation of gold nanoparticles was verified by fourier-transform infrared spectroscopy (FT-IR). X-ray powder diffraction (XRD) confirmed the crystalline nature of synthesized Au (0) NPs.The standard condition employed for the optimization of this experiment. The effects of Tet-Au(0) NPs were checked on Salmonella typhimurium (S. typhimurium). Well diffusion method was used to check the antibacterial activity on S. typhimurium, and inhibition zone was measured in mm to check capability of the Tet-Au(0) NPs. The results were compared with standard tetracycline and gold ions. The antibacterial results revealed that newly synthesized (Tet-Ag(0) NPs) had a great remarkable activity against Salmonella typhimurium. These findings could pave the way for finding the changing behavior associated with other antibiotics after capping AuNPs or other metal nanoparticles and may be used against other resistant strains.
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