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کر کے قول قرار دے بھج جانا
کر کے قول قرار دے بھج جانا
چنگا نہیں ہوندا لا کے پج جانا
ہک وار تاں یار ملا ربا
اساں ویکھدیاں سار ای رج جانا
پردہ رکھیے کسے دا رب آکھے
کم مرد دا اے پردہ کج جانا
دکھی دل نوں جنھاں نے جت لیا
کر سمجھ لے اوہناں نیں حج جانا
کم شہر دے وچ نہیں کوئی اے پر
گلی سجناں دی کسے پج جانا
اوکھے ویلے جو یار نہ کم آوے
چنگا ہوندا اے اوس توں بھج جانا
شیخ الحدیث مولانا سلیم اللہ خان کی تصنیفی خدمات
Sheikh Molana saleem ullah khan was born in Muzaffer Nagar in India. He belongs to hasan pur. He get degree of dura-e-nizami from Dar-ul-Uloom Deoband. In Deoband he received Education of Quran, Hadith and other related sciences through learned scholars of the time which includes Molana Hussain Ahmed Madani, Molana Izaz Ali, Molana Idrees kandahalvi and other religious personalities. After his education he start teaching and served as a teacher in many madaris. He was a prominent and renowned scholar.1n 1967 He laid the foundation of Jamia Farooqia Karachi. His entire services have been so much blessed by Almighty Allah that since its foundation, till now the Jamia has advanced a long way in Islamic Education and related fields which seems almost unbelievable. He left many books which based on his writing and narration of Hadith during different session of dura-e-Hadith. In this Article, I have tried my level best to elaborate sheikh saleem Ullah khan’s services as Author for Islamic literature and specially for Hadith Nabvi(s.w).Common Fusion Oncogenes in Pediatric Acute Lymphoblastic Leukemia and Their Role in Differential Diagnosis and Prognosis
Acute lymphoblastic leukemia (ALL) is a complex genetic disease involving many fusion oncogenes having prognostic significance. The frequency of various fusion oncogenes can vary in different ethnic groups, with important implications for prognosis, drug selection and treatment outcome. We studied fusion oncogenes in 101 pediatric ALL patients using RT-PCR and interphase FISH, and their associations with clinical features and treatment outcome. Five most common fusion genes i.e. BCR-ABL t (22; 9), ETV6-RUNX1 (t 12; 21), MLL-AF4 (t 4; 11) TCF3-PBX1 (t 1; 19), and SIL-TAL1 (del 1p32) were found in 88.1% (89/101) patients. Frequency of BCR-ABL was 44.5% (45/101). BCR-ABL positive patients had a significantly lower survival (43.7±4.24 weeks) and higher white cell count as compared to others, except patients with MLL-AF4. The highest relapse-free survival was documented with ETV6-RUNX1 (14.2 months) followed closely by those cases in which no gene was detected (13.100). RFS with BCR-ABL, MLL-AF4, SIL-TAL1 and TCF3-PBX1 was less than 10 months (8.0, 3.6, 5.5 and 8.1 months, respectively). This is the first study from Pakistan correlating molecular markers with disease biology and treatment outcome in pediatric ALL. It revealed the highest reported frequency of BCR-ABL fusion gene in pediatric ALL, associated with poor overall survival. Present data indicated an immediate need for incorporation of tyrosine kinase inhibitors in the treatment of BCR-ABL+ pediatric ALL in this population and the development of facilities for stem cell transplantation.Journals by Discipline
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