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غزل
دل سے اک شخص کی یادوں کو رہا کرتے ہوئے
مر ہی جاوں نہ کہیں اس کو قضا کرتے ہوئے
تو کہ معبود سے نگران بھی سکتا ہے
میں نے سوچا ہی نہ تھا تجھ کو خدا کرتے ہوئے
ہاتھ اٹھاتے ہوئے وہم و گماں میں بھی نہ تھا
لب پہ اک نام جو آیا ہے دعا کرتے ہوئے
ہر کہانی کے قلم کار نے کیوں مار دیے
سارے کردار محبت میں وفا کرتے ہوئے
ہاتھ میں رنگ رکھا ، باد صبا پر آنکھیں
پھول سے پھول کی خوشبو کو جدا کرتے ہوئے
شہر کا شہر ہی ویران نہ ہو جائے کہیں
میرے اک خواب کو تعبیر نما کرتے ہوئے
اب تو میں لوٹ کے جنگل میں نہیں جا سکتا
کھو گیا ہوں میں ترے گھر کا پتا کرتے ہوئے
تو کہے تو میں ترے دل سے نکل جاتا ہوں
میں نے جنت بھی چھوڑی تھی خطا کرتے ہوئے
آندھیوں سے تو مری جنگ نہیں ہے کوئی
شمع تو بجھنے نہ دی ذکر ہوا کرتے ہوئے
میں نے خیرات میں بھی پیار ہی مانگا ہے عدید
سوچتے کیا ہے سخی مجھ پہ عطا کرتے ہوئے
Muslim-Christian Relationship in the Context of Status of Prophet Muhammad SAW
The question of the status of Prophet Muhammad has been one of the most crucial and controversial issue of Muslims-Christian relations since the advent of Islam. In almost every Muslim-Christian encounter, the question of Christian acknowledgement of prophet-hood of Muhammad has been raised. Muslim ask, when we accept and regard Jesus as a prophet, why you (Christian) do not recipro-cate by giving the same status to prophet Muhammad. The present study is an attempt to analyze the points which Kenneth Cragg has raised, In response of the Muslims, who say, why the Christian don’t give such respect to Muhammad(SAW) as the Muslim give to Jesus. In this study I proved that Cragg’s answer is not only against the Holy Quran but also against The teachings of Gospel and the only reason for this disregard Is prejudicial and polemical.Computer-Guided Design and Synthesis of Il-2 Inhibitors As Immunomodulating Agents
Cytokine Interleukin-2 (IL-2) has a prevalent role in the growth, activation, and differentiation o f T-cells. To suppress immune responses associated with organ transplant rejection and other autoimmune diseases, it is important to disrupt the interaction of IL-2 with its receptor system. IL-2 is now emerging as a target in the discovery of novel therapeutics for addressing the problems related to immune system. The main goal of this study was to establish an effective in silico protocol for identification of IL-2 inhibitors. It describes a pharmacophore based virtual screening combined with docking study as a rational strategy for identification of novel IL-2 inhibitors. Structure based pharmacophore model was developed using the crystal structure of IL-2/IL-2Rα (PDB ID: 1Z92) complex. The predictive pharmacophore model consisted of three features, two hydrophobic and one cationic feature with three excluded volumes. The pharmacophore was validated using a training set of thirty known IL-2 inhibitors. Pharmacophore model as a 3D search query was searched against ZINC and MOE database, in order to retrieve new chemical scaffolds that may be potent IL-2 inhibitors. The hits retrieved from this search were filtered based on their RMSD values and pharmacophoric features. Hits that were retained were used in a molecular docking study to find the binding mode and molecular interactions with crucial residues at the active site of the target. Pharmacophore based molecular docking was carried out on virtually screened compounds using 1Z92 as target by MOE software that led to the identification of 15 hits belonging to diverse classes of heterocycles. These hits were further optimized and a library of forty six compounds including 5-6 membered azaheterocycles namely dihydropyrimidines, heteroazepines, pyrazoles and benzimidazoles besides some compounds such as chalcones and Schiff bases, was designed and synthesized. All newly synthesized compounds were characterized by their MS and NMR spectral analysis. IL-2 inhibition studies on the members of the synthesized library led to the identification of novel IL-2 inhibitors with IC 50 values ranging from <2- >50μg/ml using cyclosporine as a standard drug. This entire set of experiments in both dry and wet labs led to a successful designing and synthesis of a variety of compounds as novel scaffolds that may be developed into interesting immunomodulators.Journals by Discipline
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