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ادارہ (ایم پی ڈی ڈی) لاہور کا آنکھوں دیکھا حال

ادارہ MPDD لاہور کاآنکھوں دیکھا حال
(ڈپٹی ڈسٹرکٹ اٹارنی محمداسلم بھٹی بہاول نگر والے کی فرمائش پر لکھی گئی نظم )
آنکھوں دیکھا حال ہم تم کو سنائیں گے
کیسے گزرے MPDD میں دن منظر عام پرلائیں گے
شروع شروع میں آئے یہاں پر دل ہمارے مسرور تھے
پہلے دن تھی خوش طبیعت خوشی کے نشے میں چور تھے
سوچ میں ڈوبے بنے منصوبے فکروں سے ہم دور تھے
بے فکری پر اتنے کھاتے سوچا دوستوں کو بلوائیں گے
اتنے بہت زیادہ خوش ذائقہ تھے کھانے
عزت نفس مطلوب تھی جس کو ہر کوئی جانے
حاضر رہن دماغ ہمارے جیسے مراقبہ میں درویش سیانے
انگلش میں سوال و جواب وہ کیفیت نہ بتلائیں گے
وقت مقررہ ٹائمنگ ملتی دیر ذرا نہ کرتے تھے
دوستوں کو جب ملتے تو دل ہمارے نہ بھرتے تھے
ایسے ہوئے حالات ہمارے پل پل جیتے مرتے تھے
جیسے ہوں گے حالات ہمارے پھر بھی نہ گھبرائیں گے

حال ہمارا ایسا تھا جتنے چست چالاک بھی تھے
ذہنوں میں کچھ خوف تھا کچھ وہ کرب ناک بھی تھے
کئی ہم میں ایسے تھے جو صاحب خوش پشاک بھی تھے
تہم ہی بتائو کیسے ہم پھر سکھ کی سیج سجائیں گے
تربیت گاہ کے حال میں جب SO تشریف لاتے تھے
انگلش جن کی ویک تھی وہ بہت ہی گھبراتے تھے
سی سی ٹی وی کیمرے سارا حال بتاتے تھے
آئے پسینے دھڑکن سینے سوچا چین سکون نہ پائیں گے
چاولہ سائیں ؔہر مشکل کے بعد ہوتی ہے آسانی
اس دنیا میں اچھا کرجا تیری رہ جائے گی کہانی
مال و دولت دنیا ساری ایک دن ہوجائے گی بیگانی
وہ وقت بھی آئے گا جب ہم بہت...

The Enigma of Stable Employment: Does Job Security Really Make Difference in Employee Performance?

Employees are the precious assets of organizations and play a vital role in success or failure of any organization. Job security is one of the main goals of employees in Pakistan. It is also considered one of the important factors for job attitude. As it has been considered and supported by researches that job security creates job satisfaction and job satisfaction has positive relationship with performance. This research explored relationship between job security and job performance of employees in organization. The sample consists of 60 employees from nine organizations of District Badin (Private, Public & NGOs), convenient sampling technique was used. Close-ended Questionnaire was divided in two portions, the first portion comprises on 6 items about job security that was filled by employees, and the second portion consists of 15 items about job performance and was filled by their bosses afterward. Data was analyzed using SPSS 22.0 in terms of Descriptive Statistics and Pearson Correlation. Non-confirmed employees are performing better as compared to confirmed employees due to fear of loss of job at any time as they believe that performance causes to get a job secured. Results demand for serious consideration about motivation, evaluation, confirmation and probation policies in organizations.

Identification and Significance of Tumor Marker Muc1/Ca 15-3, in Metastatic Breast Cancer

Disease associated risk factors in premenopausal women includes professional and household stresses. While in post menopausal women the major factor is sedentary life style. Physiological characteristic have shown that the major risks associated with the aggressiveness of tumor are the receptor status especially triple negative (ER, PR and her2/neu) in both premenopausal and post menopausal women. Techniques of ELISA SEC, HPLC were tried to find out the method for estimation of the level of MUCI/CA15- 3 that showed an early detection and that was also economical. Computational protein modeling was used to predict secondary structure of MUC1. Predicted secondary structure of MUC1/CA 15-3 contains 6.0% helix, 7.9% strand or β-pleated sheet and 86.1% loop. Percentage composition shows an increased number of alanine, proline, serine, tyrosine, valine and glycine in helix, strand and turn or loop structure that indicates its basic and hydrophobic characteristics. MUC1/CA 15-3 comprises of an extracellular domain and a membrane associated domain. A junction of 3 amino acid units i.e. Cys-Gln-Cys between the extracellular subunit and transmembrane subunit is also observed. This motif is necessary for surface expression. The extracellular subunit consists of a tandem repeat unit that consist 20 amino acid residues i.e sapdnkpags and tappahgvts. This region of MUC1 may be used as vaccine for breast cancer. The subcellular subunit of MUC1 mainly consists of immunodominant DTR motif at 922 postion of the domain, is haeavily glycosylated and may protect the cell from any of the foreign body or tumor cell. The other subunit of MUC1/CA 15-3 consists of 17 amino acid residues. This subunit is associated with the plasma membrane. xixPost translational modifications (glycosylation, phosphorylation and myristoylation) are mainly observed in extracellular subunit. Several phosphorylation sites, Myristoylation sites and some glycosylation sites of tandem repeat region were predicted in MUC1/CA 15-3. It was observed that due to these modifications, the protein performed different functions. Alignment of the sequence of MUC1/CA 15-3 with the other family member of mucins (MUC2- MUC12) shows highest homology of MUC1/CA 15-3 with MUC4. The property of breast tumor to produce mucinous antigen was used for the synthesis of vaccine using the experimental mice. Electrophoretic technique was used to confirm the production of antibody that may be effective against antigen of MUC1/CA 15-3. The conclusion is that CA 15-3 is a transmembrane glycoprotein having basic and hydrophobic charecterstics. The most important part of this protein is extracellular and transmembrane subunits. These subunits of protein undergo posttranslational modification and are important in immunization and vaccine formation.
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Asian Research Index Whatsapp Chanel

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