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مولاناسید شاہ محمد قمر الدین پھلواروی

مولانا سید شاہ محمد قمرالدین پھلواروی
یہ خبر بھی افسوس کے ساتھ سنی جائے گی کہ مولانا سید شاہ محمد قمرالدین صاحب پھلواروی، امیر شریعت صوبہ بہار نے ۳۱؍ جنوری کو انتقال فرمایا، مرحوم مولانا سید شاہ بدرالدین صاحب مرحوم، امیر شریعت اول کے صاحبزادے اور علم و عمل میں اپنے اسلاف کرام کے خلف الصدق تھے، اپنے بڑے بھائی مولانا سید شاہ محی الدین صاحب مرحوم امیر شریعت ثانی کے انتقال کے بعد ان کے جانشین ہوئے اور امارت شرعیہ کی روایات اور اس کے مذہبی کاموں کو پوری طرح قائم و برقرار رکھا، ان کی وفات سے خاندان پھلواروی کی ایک اہم یادگار مٹ گئی، اﷲ تعالیٰ ان کو اپنی رحمت و مغفرت سے سرفراز فرمائے اور ان کے اخلاف کو ان کے نقش قدم پر چلنے کی توفیق بخشے۔ (شاہ معین الدین ندوی، مارچ ۱۹۵۷ء)

 

فتح مکہ میں آنحضرت ﷺ کی حربی حکمت عملی

This article encompassed the Holy Prophet's (ﷺ) best war strategy in the conquest of Makkah and its relevance to the Modern society. The purpose of this article was to highlight the war strategy of Holy Prophet (ﷺ) in the conquest of Makkah. His strategy provided the noble example for warfare in modern world. The method used for research was historical. The review of literature revealed that the war, humanity for love the showed (صلى الله عليه وسلم) Muhammad Prophet of strategies concern for the safety of the lives and avoided bloodshed as far as possible. Because of his noble strategies, Makkan tribes surrendered without any resistance in front of the army of Islam. Consequently, (صلى الله عليه وسلم) Prophet Holy the and idolatry from freed became Makkah conquered the last and the most solid stronghold of the enemy. In Modern era, Muslim faced so many war problems. Through the war war the learn can commanders military, (صلى الله عليه وسلم) Prophet Holy of strategies ethics and overcome their problems. It is recommended to Muslim army that they should take guidance from the war strategy of Prophet pressure psychological putting by enemy defeat and (صلى الله عليه وسلم) Muhammad upon them.

A Prospective Analysis of Association of Vitamin D Deficiency With Mammary Epithelial Cell Proliferation & Mammographyic Density in Premenopausal Women

In females, breast cancer is the most common cancer along with being one of the leading causes of cancer deaths worldwide. The known risk factors associated with breast cancer are both non-modifiable and modifiable. Factors like Vitamin D and mammographic density are few of the modifiable factors in breast cancer prevention which have recently been emphasized upon. Vitamin D is the talk of all researchers with more emphasis on its non-bone effects. In the recent past, it has been found to modulate breast epithelial cell proliferation, for both normal and cancerous cells. Many studies have endorsed the fact that vitamin D may be associated with reduced breast cancer risk. The hypothesis was ―vitamin D deficiency is associated with epithelial cell proliferation and mammographic density.‖ The primary objective of this thesis was to evaluate the effect of vitamin D deficiency and its association with epithelial cell proliferation and mammographic density in the reproductive age group. Mammographic density was estimated using the fullyautomated software Volpara. Secondary objectives were to find out the effect of the enzyme 1 alpha Hydroxylase, DNA quantification and Vitamin D receptor gene polymorphism (fok1 and Apa1) by using PCR/RFLP. The epithelial cell proliferation was studied by performing FNAC on palpable lumps and utilizing ―countess‖ to count the viable and non-viable cells present in the tissue. This was a prospective, open label, clinical trial. The total cases were recruited from the surgical OPD of Patel Hospital, Karachi (n=350) and were supplemented with vitamin D. The study was carried out from June 2013-March 2015. The results were favorable in most patients, with general increase of vitamin 25(OH) D levels after supplementation (baseline mean ± SD: 9.88 ± 7.3; median 7.0; range 3– 49.8) to 68.3 + 25.5; 66; 30.1-150, p< 0.001), a mean difference of 58.4 between vitamin D level at baseline and 12 months. There was a weak, positive Spearman''s rankxx order correlation between 1 alpha Hydroxylase at 12 months and vitamin D at baseline; 12 months (rs= 0.169, p= 0.126,rs= 0.079,p=0.480).A moderate negative correlation was found between vitamin D baseline – Volumetric breast density (VBD) baseline and vitamin D 12 months – VBD 12 months (rs= -0.245, p= <0.001,rs= -0.289, p=0.193) respectively. No statistically significant association was found between vitamin D at baseline and BI-RADS at baseline (p= 0.126). A Kruskal-Wallis H test showed that there was statistically significant difference in VBD at baseline between the different BI-RADS groups, χ2(3) = 169.4, p<0.001, with a mean rank of 6 for BI-RADS 1, 36.11 for BIRADS 2,105.67 for BI-RADS 3, and 176.55 for BI-RADS 4. A negligible or no correlation was found between vitamin D baseline with levels of proliferation in breast cells (total cell count rs= -0.020, p=0.906; dead cell count rs= -0.005, p=0.979; viable cell count rs= -0.072, p= 0.672). VBD was moderate and negatively correlated with dead cell count (rs= -0.436, p=0.018) while weak negative correlation was observed between VBD and total cell count (rs=-0.130,p=0.502). The conclusion is that an optimal level of vitamin D has to be maintained ;if not then vitamin D level falls to its original deficient level in two months time. There is a need to establish a universal definition of vitamin D deficiency to allow better comparability of studies at the global level. Only through the identification of modifiable risk factors associated with this disease, can effective cancer prevention be realized.
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