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18. Al-Kahf/The Cavern

18. Al-Kahf/The Cavern

I/We begin by the Blessed Name of Allah

The Immensely Merciful to all, The Infinitely Compassionate to everyone.

18:01.
All Praise and Gratitude is to Allah - The One and Only God of everyone,
WHO has sent down The Divine Book to HIS Servant Muhammad.
And HE has not made any deviousness in it - straight and upright in terms of the perfection of its words, text, and meanings.

18:02
HE has made it a straightforward Book -
meant to warn people of severe punishment from HIM in case of their continued disbelief,
and to give the good news to the believers who practice righteousness -
that for them will be a beautiful reward – Paradise,

18:03
a. Paradise - wherein they will live forever – never to leave, never to die.

18:04
Furthermore, it is meant to warn those who allege:
‘Allah has taken to HIMSELF a son.’

18:05
They have no knowledge about it, nor had their forefathers.
It is really a monstrous assertion of blasphemy that is coming out of their mouths!
They utter nothing but an absolute falsehood against Allah.

18:06
O The Prophet!
You are aggrieved by the hostility aroused by the Divine Message among the polytheists.
Then perhaps you are going to destroy yourself with grief and anguish for their sake
if they are not believing in this Proclamation - The Qur’an.

18:07
This is a reality that WE have made all that is in the terrestrial world,
- a splendor and beauty for it so that WE may test people to see which of them is better in terms of...

حضرت مولانا عبد الغنی ’’حاجی صاحب‘‘ کا تعارف و خدمات

Allah has created this universe and for guidance of people he has sent his different holy books and with those books he has sent different holy messengers. The messengers of Allah came to this world and preached the message was written in his books. When his messengers completed their job then their duty was given to the scholars of Islam. They also preached Islam from place to place and they face many difficulties and hardships but they continue their message. Among all these scholars some of them worked hard for writing and teaching the holy Quran to other people. Molana Abdul Ghani is one of these scholars who spent all of his time to serve Islam and preaching of Islamic thoughts. In this paper will present the Services and Introduction of Molana Haji Abdul Ghani.

Mutation Spectrum in Pakistani Patients With Inherited Metabolic Disorders

Inherited metabolic disorders constitute a diverse class of genetic diseases caused by impairment in biochemical processes because of defective enzymes or transporters consequent upon which compromised conversion of substrate into the product takes place. These disorders are manifested phenotypically with a wide overlapping spectrum of signs and symptoms that could either be due to accumulation of toxic upstream substrates, insufficient production of downstream products or abnormal alternative substrate metabolism. Biochemical and molecular investigations help in diagnosis of hereditary metabolic disorders and that if attempted early, could improve therapeutic outcome in some cases. The current study was performed to investigate the spectrum of genetic variants in Pakistani patients with inherited metabolic disorders. A cohort of sixty-eight patients was enrolled in the study from local hospitals. Twenty-five of these patients were diagnosed with inherited unconjugated hyperbilirubinemias, one with GM1 gangliosidosis, nineteen with various types of mucopolysaccharidoses (MPS), and twenty-three with Wilson’s disease. Genomic DNA samples of these patients were subjected to Sanger sequencing of respective genes. The identified variants were confirmed in families of the patients for segregation. Sequence analysis of UGT1A1 in twenty-five patients diagnosed with inherited unconjugated hyperbilirubinemias identified 16 different variants, six of which were novel. The c.622-625dupCAGC and c.1021C>T were the most frequently observed UGT1A1 variants. DNA sequencing of GLB1 in one patient diagnosed with GM1 gangliosidosis identified a novel homozygous 2-bp deletion c.881-882delAT (p.Tyr294Terfs) in exon 8. Among nineteen patients diagnosed with various types of mucopolysaccharidoses during the study period, MPS type I was the most prevalent phenotype. DNA sequencing of IDUA in MPS type I patients revealed a diverse spectrum of variants spanning the whole gene. A missense variant c.1469T>C (p.Leu490Pro) was the most common variant identified in five patients in homozygous condition. Mutations identified in other MPS types were all private mutations and include c.1006+1G>C, c.1165C>T in IDS, c.531+5G>A in NAGLU, c.902G>A, c.1175C>T, c.IVS4-1G>A in GALNS and c.511-512delGG in ARSB. DNA sequencing in a cohort of twenty-three Wilson’s disease patients identified a diverse spectrum of 18 ATP7B variants spanning over the whole gene. The mutation detection rate was 71.7% and seven of the identified variants were novel. The most frequently observed ATP7B variant was c.3809A>G followed by c.3182G>A. To our knowledge, this is the first comprehensive study of inherited metabolic disorders from Pakistan. It should be helpful in neonatal screening, improved genetic counseling, and prenatal diagnosis in the affected families.
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